{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:54:55Z","timestamp":1790031295561,"version":"4.0.1"},"reference-count":18,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T00:00:00Z","timestamp":1693785600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontierspartnerships.org"],"crossmark-restriction":true},"short-container-title":["Transpl Int"],"abstract":"<jats:p>The reporting of serious adverse events (SAE) and serious adverse reactions (SAR) is an essential part of an effective vigilance and surveillance system (V&amp;amp;S) in organ donation and transplantation. All SAE and SAR reported to the German organ procurement organization (DSO) between 2016 and 2022 were analyzed. In case of a possible transmission of a disease to one or more recipients, an assessment of imputability was done according to the grading system of the US Disease Transmission Advisory Committee (DTAC). 543 SAE and SAR cases were reported to the DSO and analyzed in detail. 53 of the 543 reports (9.8%) were proven or probable (P\/P) transmissions of infectious diseases, malignancies or other diseases to 75 recipients. Infections were the most frequently reported P\/P disease transmission occurrences (30\/53, 57%). In case of disease transmission, the mortality of the recipients was high (17\/75, 23%), especially when a malignant disease was transmitted (11\/22, 50 %). Donor-Derived disease transmission is a rare event (53\/8,519; 0.6 %), but when it occurs can lead to significant morbidity and mortality.<\/jats:p>","DOI":"10.3389\/ti.2023.11610","type":"journal-article","created":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T07:59:57Z","timestamp":1693814397000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Vigilance Data in Organ Donation and Solid Organ Transplantation in Germany: Six Years of Experience 2016\u20132022"],"prefix":"10.3389","volume":"36","author":[{"given":"Klaus","family":"B\u00f6hler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Rahmel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula","family":"Barreiros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,9,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1097\/TP.0000000000001635","article-title":"Strategies for an Expanded Use of Kidneys From Elderly Donors","volume":"101","author":"P\u00e9rez-S\u00e1ez","year":"2017","journal-title":"Transplantation"},{"key":"B2","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1111\/tri.13086","article-title":"Organ Transplantation From \"Increased Infectious Risk Donors\": The Experience of the Nord Italia Transplant Program - A Retrospective Study","volume":"31","author":"Grossi","year":"2018","journal-title":"Transpl Int"},{"key":"B3","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1097\/MOT.0000000000000735","article-title":"Increased-Risk Donors and Solid Organ Transplantation: Current Practices and Opportunities for Improvement","volume":"25","author":"Brown","year":"2020","journal-title":"Curr Opin Organ Transpl"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1111\/j.1600-6143.2011.03493.x","article-title":"An Update on Donor-Derived Disease Transmission in Organ Transplantation","volume":"11","author":"Ison","year":"2011","journal-title":"Am J Transpl"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1097\/TP.0b013e318272df41","article-title":"Cancer Transmission From Organ Donors-Unavoidable but Low Risk","volume":"94","author":"Desai","year":"2012","journal-title":"Transplantation"},{"key":"B6","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1097\/MOT.0000000000000551","article-title":"Donor-Derived Infections, Lessons Learnt From the Past, and What Is the Future Going to Bring Us","volume":"23","author":"Grossi","year":"2018","journal-title":"Curr Opin Organ Transpl"},{"key":"B7","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1111\/ajt.16178","article-title":"Ten Years of Donor-Derived Disease: A Report of the Disease Transmission Advisory Committee","volume":"21","author":"Kaul","year":"2021","journal-title":"Am J Transpl"},{"key":"B8","doi-asserted-by":"publisher","first-page":"10092","DOI":"10.3389\/ti.2021.10092","article-title":"Donor-Transmitted Cancer in Orthotopic Solid Organ Transplant Recipients: A Systematic Review","volume":"35","author":"Greenhall","year":"2022","journal-title":"Transpl Int"},{"key":"B9","doi-asserted-by":"publisher","first-page":"e12","DOI":"10.1097\/TP.0000000000003995","article-title":"Prevention and Management of Donor-Transmitted Cancer After Liver Transplantation: Guidelines From the ILTS-SETH Consensus Conference","volume":"106","author":"Dom\u00ednguez-Gil","year":"2022","journal-title":"Transplantation"},{"key":"B10","volume-title":"The Guide to the Quality and Safety of Organs for Transplantation","year":"2022"},{"key":"B11","first-page":"30","volume-title":"Recommendations on the Vigilance of Human Organs Intended for Transplantation Deliverable 10 (Part II)","year":"2011"},{"key":"B12","volume-title":"Directive 2010\/53\/EU of the European Parliament and of the Council of 7 July 2010 on Standards of Quality and Safety of Human Organs Intended for Transplantation","year":"2010"},{"key":"B13","volume-title":"Directive 2012\/25\/EU of 9 October 2012 Laying Down Information Procedures for the Exchange, Between Member States, of Human Organs Intended for Transplantation","year":"2012"},{"key":"B14","volume-title":"Verordnung \u00fcber die Anforderungen an die Organ- und Spendercharakterisierung und an den Transport von Organen sowie \u00fcber die Anforderungen an die Meldung schwerwiegender Zwischenf\u00e4lle und schwerwiegender unerw\u00fcnschter Reaktionen vom 11. 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