{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T02:05:25Z","timestamp":1789005925703,"version":"build-2803163510"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T00:00:00Z","timestamp":1725840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontierspartnerships.org"],"crossmark-restriction":true},"short-container-title":["Transpl Int"],"abstract":"<jats:p>Heart transplant patients have an increased risk of developing cancer. Patients who underwent HTx between 1985 and 2017 were included. Detection of cancer was obtained by cross-checking the study population with the Swedish Cancer-Registry and the Cause-of-Death-Registry. A total of 664 patients were followed for a median of 7.7\u00a0years. In all, 231 malignancies were diagnosed in 138 patients. Compared to the general population the excess risk of cancer following HTx was 6.2-fold calculated as the standardized incidence ratio (SIR) and 2.9-fold after exclusion of non-melanoma skin cancer (NMSC). The most common malignancies were NMSC, non-Hodgins lymphoma, and lung cancer. There was no significant difference in overall survival between those with and without a history of cancer before HTx (<jats:italic>p<\/jats:italic> = 0.53). During a median follow-up of 7.7\u00a0years, 19% of HTx recipients developed cancer, 6.2-fold higher relative to the general population, and 2.9-fold higher when excluding NMSC. Risk factors for malignancies (excluding NMSC) included previous smoking, hypertension and prolonged ischemic time; and for NMSC, increasing age, seronegative CMV-donors, and azathioprine. A previous cancer in selected recipients results in similar survival compared to those without cancer prior to HTx.<\/jats:p>","DOI":"10.3389\/ti.2024.12109","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T09:18:05Z","timestamp":1725873485000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Malignancies After Heart Transplantation"],"prefix":"10.3389","volume":"37","author":[{"given":"Caroline","family":"Stenman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Wallinder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Holmberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristjan","family":"Karason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper","family":"Magnusson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6ran","family":"Dellgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,9,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2300","DOI":"10.1002\/cncr.28043","article-title":"Cumulative Incidence of Cancer After Solid Organ Transplantation","volume":"119","author":"Hall","year":"2013","journal-title":"Cancer"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1038\/sj.bjc.6601219","article-title":"Cancer Risk Following Organ Transplantation: A Nationwide Cohort Study in Sweden","volume":"89","author":"Adami","year":"2003","journal-title":"Br J Cancer"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1889","DOI":"10.1111\/j.1600-6143.2010.03181.x","article-title":"Comparison of the Incidence of Malignancy in Recipients of Different Types of Organ: A UK Registry Audit","volume":"10","author":"Collett","year":"2010","journal-title":"Am J Transplant"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1002\/ijc.24439","article-title":"Cancer Incidence and Risk Factors After Solid Organ Transplantation","volume":"125","author":"Vajdic","year":"2009","journal-title":"Int J Cancer"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1002\/ijc.27765","article-title":"Risk of Skin Cancer and Other Malignancies in Kidney, Liver, Heart and Lung Transplant Recipients 1970 to 2008--A Swedish Population-Based Study","volume":"132","author":"Krynitz","year":"2013","journal-title":"Int J Cancer"},{"key":"B6","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1016\/j.healun.2007.05.019","article-title":"Incidence of Malignancies in Heart and\/or Lung Transplant Recipients: A Single-Institution Experience","volume":"26","author":"Roithmaier","year":"2007","journal-title":"J Heart Lung Transplant"},{"key":"B7","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/S0190-9622(00)90154-3","article-title":"Skin Cancer in Kidney and Heart Transplant Recipients and Different Long-Term Immunosuppressive Therapy Regimens","volume":"42","author":"Jensen","year":"1999","journal-title":"J Am Acad Dermatol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1111\/j.1600-6143.2008.02196.x","article-title":"Malignancy After Heart Transplantation: Incidence, Prognosis and Risk Factors","volume":"8","author":"Crespo-Leiro","year":"2008","journal-title":"Am J Transplant"},{"key":"B9","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1080\/02841860802247664","article-title":"The Completeness of the Swedish Cancer Register: A Sample Survey for Year 1998","volume":"48","author":"Barlow","year":"2009","journal-title":"Acta Oncol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1007\/s10654-009-9350-y","article-title":"The Swedish Personal Identity Number: Possibilities and Pitfalls in Healthcare and Medical Research. 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