{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T13:36:05Z","timestamp":1793280965966,"version":"4.5.0"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontierspartnerships.org"],"crossmark-restriction":true},"short-container-title":["Transpl Int"],"abstract":"<jats:p>\n                    Delayed graft function (DGF) after kidney transplantation is common and associated with worse graft outcomes. However, little is known about factors affecting graft survival post-DGF. We studied the association of cold ischemia time (CIT) and Kidney Donor Profile Index (KDPI) with the long-term outcomes of deceased brain-dead donor kidneys with and without DGF. Data from Finland (\n                    <jats:italic>n<\/jats:italic>\n                    = 2,637) and from the US Scientific Registry of Transplant Recipients (SRTR) registry (\n                    <jats:italic>n<\/jats:italic>\n                    = 61,405) was used. The association of KDPI and CIT with the graft survival of kidneys with or without DGF was studied using multivariable models. 849 (32%) kidneys had DGF in the Finnish cohort. DGF and KDPI were independent risk factors for graft loss, [HR 1.32 (95% CI 1.14\u20131.53),\n                    <jats:italic>p<\/jats:italic>\n                    &amp;lt; 0.001, and HR 1.01 per one point (95% CI 1.01\u20131.01),\n                    <jats:italic>p<\/jats:italic>\n                    &amp;lt; 0.001, respectively], but CIT was not, [HR 1.00 per CIT hour (95% CI 0.99\u20131.02),\n                    <jats:italic>p<\/jats:italic>\n                    = 0.84]. The association of DGF remained similar regardless of CIT and KDPI. The US cohort had similar results, but the association of DGF was stronger with higher KDPI. In conclusion, DGF and KDPI, but not CIT, are independently associated with graft survival. The association of DGF with worse graft survival is consistent across different CITs but stronger among marginal donors.\n                  <\/jats:p>","DOI":"10.3389\/ti.2024.12309","type":"journal-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T12:25:09Z","timestamp":1709295909000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":22,"title":["Characteristics of Delayed Graft Function and Long-Term Outcomes After Kidney Transplantation From Brain-Dead Donors: A Single-Center and Multicenter Registry-Based Retrospective Study"],"prefix":"10.3389","volume":"37","author":[{"given":"Amanda","family":"Ahlmark","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ville","family":"Sallinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verner","family":"Eerola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko","family":"Lempinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilkka","family":"Helanter\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,3,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2279","DOI":"10.1111\/j.1600-6143.2010.03179.x","article-title":"A Risk Prediction Model for Delayed Graft Function in the Current Era of Deceased Donor Renal Transplantation","volume":"10","author":"Irish","year":"2010","journal-title":"Am J Transpl"},{"key":"B2","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1159\/000491558","article-title":"Delayed Graft Function: The AKI of Kidney Transplantation","volume":"140","author":"Mannon","year":"2018","journal-title":"Nephron"},{"key":"B3","doi-asserted-by":"publisher","first-page":"2279","DOI":"10.1111\/j.1600-6143.2011.03754.x","article-title":"Delayed Graft Function in the Kidney Transplant","volume":"11","author":"Siedlecki","year":"2011","journal-title":"Am J Transpl"},{"key":"B4","doi-asserted-by":"publisher","first-page":"R121","DOI":"10.1186\/cc10220","article-title":"Deceased Donor Neutrophil Gelatinase-Associated Lipocalin and Delayed Graft Function After Kidney Transplantation: A Prospective Study","volume":"15","author":"Hollmen","year":"2011","journal-title":"Crit Care"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1111\/ajt.12210","article-title":"Summary of FDA Workshop on Ischemia Reperfusion Injury in Kidney Transplantation","volume":"13","author":"Cavaille-Coll","year":"2013","journal-title":"Am J Transpl"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1093\/ndt\/gfn667","article-title":"Association Between Delayed Graft Function and Allograft and Patient Survival: A Systematic Review and Meta-Analysis","volume":"24","author":"Yarlagadda","year":"2009","journal-title":"Nephrol Dial Transpl"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1111\/tri.13654","article-title":"Relevance of KDPI Value and Acute Rejection on Kidney Transplant Outcomes in Recipients With Delayed Graft Function - a Retrospective Study","volume":"33","author":"Arias-Cabrales","year":"2020","journal-title":"Transpl Int"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1097\/00007890-199605150-00008","article-title":"Delayed Graft Function in the Absence of Rejection Has No Long-Term Impact. 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