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Whether systemic inflammation is different in lung donors after brain- (DBD) or circulatory-death (DCD) is unknown, but this may potentially increase the incidence of primary graft dysfunction (PGD) after lung transplantation. We compared the plasma levels of interleukin (IL)-6, IL-8, IL-10 and TNF-\u03b1 in BDB and DCD and their respective recipients, as well as their relationship with PGD and mortality after LT. A prospective, observational, multicenter, comparative, cohort-nested study that included 40 DBD and 40 DCD lung donors matched and their respective recipients. Relevant clinical information and blood samples were collected before\/during lung retrieval in donors and before\/during\/after (24, 48 and 72\u00a0h) LT in recipients. Incidence of PGD and short-term mortality after LT was recorded. Plasma levels of all determined cytokines were numerically higher in DBD than in DCD donors and reached statistical significance for IL-6, IL-10 and IL-8. In recipients with PGD the donor\u2019s plasma levels of TNF-\u03b1 were higher. The post-operative mortality rate was very low and similar in both groups. DBD is associated with higher systemic inflammation than DCD donors, and higher TNF-\u03b1 plasma levels in donors are associated with a higher incidence of PGD.<\/jats:p>","DOI":"10.3389\/ti.2024.12512","type":"journal-article","created":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T04:11:21Z","timestamp":1717387881000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":22,"title":["Systemic Inflammation Differences in Brain-vs. Circulatory-Dead Donors: Impact on Lung Transplant 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