{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:38:39Z","timestamp":1792795119828,"version":"4.5.0"},"reference-count":50,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontierspartnerships.org"],"crossmark-restriction":true},"short-container-title":["Transpl Int"],"abstract":"<jats:p>Tertiary hyperparathyroidism (THPT) is characterized by elevated parathyroid hormone and serum calcium levels after kidney transplantation (KTx). To ascertain whether pre-transplant calcimimetic use and dose information would improve THPT prediction accuracy, this retrospective cohort study evaluated patients who underwent KTx between 2010 and 2022. The primary outcome was the development of clinically relevant THPT. Logistic regression analysis was used to evaluate pre-transplant calcimimetic use as a determinant of THPT development. Participants were categorized into four groups according to calcimimetic dose, developing two THPT prediction models (with or without calcimimetic information). Continuous net reclassification improvement (CNRI) and integrated discrimination improvement (IDI) were calculated to assess ability to reclassify the degree of THPT risk by adding pre-transplant calcimimetic information. Of the 554 patients, 87 (15.7%) developed THPT, whereas 139 (25.1%) received pre-transplant calcimimetic treatment. Multivariate logistic regression analysis revealed that pre-transplant calcimimetic use was significantly associated with THPT development. Pre-transplant calcimimetic information significantly improved the predicted probability accuracy of THPT (CNRI and IDI were 0.91 [<jats:italic>p<\/jats:italic> &amp;lt; 0.001], and 0.09 [<jats:italic>p<\/jats:italic> &amp;lt; 0.001], respectively). The THPT prediction model including pre-transplant calcimimetic information as a predictive factor can contribute to the prevention and early treatment of THPT in the era of calcimimetics.<\/jats:p>","DOI":"10.3389\/ti.2024.12704","type":"journal-article","created":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T14:58:22Z","timestamp":1714575502000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Pre-Transplant Calcimimetic Use and Dose Information Improves the Accuracy of Prediction of Tertiary Hyperparathyroidism after Kidney Transplantation: A Retrospective Cohort Study"],"prefix":"10.3389","volume":"37","author":[{"given":"Manabu","family":"Okada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuhiko","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoki","family":"Himeno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenta","family":"Futamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahisa","family":"Hiramitsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Ichimori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihiko","family":"Goto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunji","family":"Narumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiko","family":"Watarai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,5,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1097\/TP.0000000000000583","article-title":"Increased Risk of All-Cause Mortality and Renal Graft Loss in Stable Renal Transplant Recipients with Hyperparathyroidism","volume":"99","author":"Pihlstr\u00f8m","year":"2015","journal-title":"Transplantation"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1016\/j.surg.2017.12.010","article-title":"Persistent Hyperparathyroidism as a Risk Factor for Long-Term Graft Failure: The Need to Discuss Indication for Parathyroidectomy","volume":"163","author":"Araujo","year":"2018","journal-title":"Surgery"},{"key":"B3","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1186\/s12882-022-02840-5","article-title":"Elevated Parathyroid Hormone One Year after Kidney Transplantation Is an Independent Risk Factor for Graft Loss Even without Hypercalcemia","volume":"23","author":"Okada","year":"2022","journal-title":"BMC Nephrol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/S0140-6736(09)60507-9","article-title":"Hyperparathyroidism","volume":"374","author":"Fraser","year":"2009","journal-title":"Lancet."},{"key":"B5","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1016\/j.amjoto.2017.06.009","article-title":"Parathyroidectomy for Tertiary Hyperparathyroidism: A Systematic Review","volume":"38","author":"Tang","year":"2017","journal-title":"Am J Otolaryngol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1111\/1744-9987.12058","article-title":"Clinical Practice Guideline for the Management of Chronic Kidney Disease-Mineral and Bone Disorder","volume":"17","author":"Fukagawa","year":"2013","journal-title":"Ther Apher Dial"},{"key":"B7","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1111\/j.1399-0012.2007.00690.x","article-title":"Elevated Calcium Phosphate Product after Renal Transplantation Is a Risk Factor for Graft Failure","volume":"21","author":"Egbuna","year":"2007","journal-title":"Clin Transpl"},{"key":"B8","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1111\/j.1399-0012.2010.01292.x","article-title":"Serum Phosphate and Calcium Concentrations Are Associated with Reduced Patient Survival Following Kidney Transplantation","volume":"25","author":"Moore","year":"2011","journal-title":"Clin Transpl"},{"key":"B9","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1002\/bjs.10554","article-title":"Systematic Review of Surgical and Medical Treatment for Tertiary Hyperparathyroidism","volume":"104","author":"Dulfer","year":"2017","journal-title":"Br J Surg"},{"key":"B10","doi-asserted-by":"publisher","first-page":"2487","DOI":"10.1681\/ASN.2015060622","article-title":"A Randomized Study Comparing Parathyroidectomy with Cinacalcet for Treating Hypercalcemia in Kidney Allograft Recipients with Hyperparathyroidism","volume":"27","author":"Cruzado","year":"2016","journal-title":"J Am Soc Nephrol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.surg.2018.04.090","article-title":"Parathyroidectomy versus Cinacalcet in the Management of Tertiary Hyperparathyroidism: Surgery Improves Renal Transplant Allograft Survival","volume":"165","author":"Finnerty","year":"2019","journal-title":"Surgery"},{"key":"B12","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1093\/ndt\/gfl583","article-title":"Decreased Renal Transplant Function after Parathyroidectomy","volume":"22","author":"Schwarz","year":"2007","journal-title":"Nephrol Dial Transpl"},{"key":"B13","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1111\/ctr.12099","article-title":"Impact of post-Kidney Transplant Parathyroidectomy on Allograft Function","volume":"27","author":"Parikh","year":"2013","journal-title":"Clin Transpl"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1016\/j.surg.2010.09.009","article-title":"An Economic Comparison of Surgical and Medical Therapy in Patients with Secondary Hyperparathyroidism--The German Perspective","volume":"148","author":"Schneider","year":"2010","journal-title":"Surgery"},{"key":"B15","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1097\/TP.0b013e318186b7fb","article-title":"Cinacalcet Increases Calcium Excretion in Hypercalcemic Hyperparathyroidism after Kidney Transplantation","volume":"86","author":"Borchhardt","year":"2008","journal-title":"Transplantation"},{"key":"B16","doi-asserted-by":"publisher","first-page":"31","DOI":"10.12659\/AOT.883809","article-title":"Development of Nephrolithiasis in a Renal Transplant Patient during Treatment with Cinacalcet","volume":"18","author":"Seager","year":"2013","journal-title":"Ann Transpl"},{"key":"B17","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.surg.2017.10.016","article-title":"Timing of Parathyroidectomy in Kidney Transplant Candidates with Secondary Hyperparathryroidism: Effect of Pretransplant versus Early or Late post-Transplant Parathyroidectomy","volume":"163","author":"Littbarski","year":"2018","journal-title":"Surgery"},{"key":"B18","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1007\/s00268-019-05124-6","article-title":"Comparison of Pre and Post-Transplant Parathyroidectomy in Renal Transplant Recipients and the Impact of Parathyroidectomy Timing on Calcium Metabolism and Renal Allograft Function: A Retrospective Single-Center Analysis","volume":"44","author":"Okada","year":"2020","journal-title":"World J Surg"},{"key":"B19","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1007\/s00268-015-3314-z","article-title":"Characteristics of Persistent Hyperparathyroidism after Renal Transplantation","volume":"40","author":"Yamamoto","year":"2016","journal-title":"World J Surg"},{"key":"B20","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.transproceed.2019.11.020","article-title":"Risk Factors and Treatment Options for Persistent Hyperparathyroidism after Kidney Transplantation","volume":"52","author":"Kirnap","year":"2020","journal-title":"Transpl Proc"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.2215\/CJN.15921221","article-title":"Machine Learning-Derived Integer-Based Score and Prediction of Tertiary Hyperparathyroidism Among Kidney Transplant Recipients: An Integer-Based Score to Predict Tertiary Hyperparathyroidism","volume":"17","author":"Hong","year":"2022","journal-title":"Clin J Am Soc Nephrol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.surg.2021.03.067","article-title":"Prevalence and Risk Factors for Tertiary Hyperparathyroidism in Kidney Transplant Recipients","volume":"171","author":"Sutton","year":"2022","journal-title":"Surgery"},{"key":"B23","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.jss.2022.12.030","article-title":"Factors Associated with Persistent Post-Transplant Hyperparathyroidism after Index Renal Transplantation","volume":"285","author":"Walkenhorst","year":"2023","journal-title":"J Surg Res"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1681\/ASN.V1341017","article-title":"The Calcimimetic Agent AMG 073 Lowers Plasma Parathyroid Hormone Levels in Hemodialysis Patients with Secondary Hyperparathyroidism","volume":"13","author":"Goodman","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1097\/01.asn.0000050224.03126.ad","article-title":"The Calcimimetic AMG 073 as a Potential Treatment for Secondary Hyperparathyroidism of End-Stage Renal Disease","volume":"14","author":"Quarles","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1111\/j.1523-1755.2005.00596.x","article-title":"Effects of the Calcimimetic Cinacalcet HCl on Cardiovascular Disease, Fracture, and Health-Related Quality of Life in Secondary Hyperparathyroidism","volume":"68","author":"Cunningham","year":"2005","journal-title":"Kidney Int"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1093\/ndt\/gfq725","article-title":"The ADVANCE Study: A Randomized Study to Evaluate the Effects of Cinacalcet Plus Low-Dose Vitamin D on Vascular Calcification in Patients on Hemodialysis","volume":"26","author":"Raggi","year":"2011","journal-title":"Nephrol Dial Transpl"},{"key":"B28","doi-asserted-by":"publisher","first-page":"19612","DOI":"10.1038\/srep19612","article-title":"PTH-Dependence of the Effectiveness of Cinacalcet in Hemodialysis Patients with Secondary Hyperparathyroidism","volume":"6","author":"Akizawa","year":"2016","journal-title":"Sci Rep"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1007\/s40265-016-0671-3","article-title":"Etelcalcetide: First Global Approval","volume":"76","author":"Blair","year":"2016","journal-title":"Drugs"},{"key":"B30","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1111\/1744-9987.13434","article-title":"Evocalcet: A New Oral Calcimimetic for Dialysis Patients with Secondary Hyperparathyroidism","volume":"24","author":"Akizawa","year":"2020","journal-title":"Ther Apher Dial"},{"key":"B31","doi-asserted-by":"publisher","first-page":"2305","DOI":"10.2215\/CJN.02110310","article-title":"Cinacalcet Effectively Reduces Parathyroid Hormone Secretion and Gland Volume Regardless of Pretreatment Gland Size in Patients with Secondary Hyperparathyroidism","volume":"5","author":"Komaba","year":"2010","journal-title":"Clin J Am Soc Nephrol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1053\/j.ajkd.2020.02.439","article-title":"Comparative Effectiveness of Calcimimetic Agents for Secondary Hyperparathyroidism in Adults: A Systematic Review and Network Meta-Analysis","volume":"76","author":"Palmer","year":"2020","journal-title":"Am J Kidney Dis"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1093\/ckj\/sfac050","article-title":"A Roadmap to Parathyroidectomy for Kidney Transplant Candidates","volume":"15","author":"Cianciolo","year":"2022","journal-title":"Clin Kidney J"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1007\/s40618-019-01075-w","article-title":"Parathyroid Hormone Reference Ranges in Healthy Individuals Classified by Vitamin D Status","volume":"42","author":"Yalla","year":"2019","journal-title":"J Endocrinol Invest"},{"key":"B35","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1136\/bmj.4.5893.643","article-title":"Interpretation of Serum Calcium in Patients with Abnormal Serum Proteins","volume":"4","author":"Payne","year":"1973","journal-title":"Br Med J"},{"key":"B36","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1053\/j.ajkd.2008.12.034","article-title":"Revised Equations for Estimated GFR from Serum Creatinine in Japan","volume":"53","author":"Matsuo","year":"2009","journal-title":"Am J Kidney Dis"},{"key":"B37","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1007\/s10157-013-0856-y","article-title":"Creatinine-Based Equation to Estimate the Glomerular Filtration Rate in Japanese Children and Adolescents with Chronic Kidney Disease","volume":"18","author":"Uemura","year":"2014","journal-title":"Clin Exp Nephrol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"e0204896","DOI":"10.1371\/journal.pone.0204896","article-title":"Phase 2b Study of Evocalcet (KHK7580), a Novel Calcimimetic, in Japanese Patients with Secondary Hyperparathyroidism Undergoing Hemodialysis: A Randomized, Double-Blind, Placebo-Controlled, Dose-Finding Study","volume":"13","author":"Akizawa","year":"2018","journal-title":"PLoS One"},{"key":"B39","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1001\/jama.2016.19468","article-title":"Effect of Etelcalcetide vs Cinacalcet on Serum Parathyroid Hormone in Patients Receiving Hemodialysis with Secondary Hyperparathyroidism: A Randomized Clinical Trial","volume":"317","author":"Block","year":"2017","journal-title":"JAMA"},{"key":"B40","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1002\/sim.2929","article-title":"Evaluating the Added Predictive Ability of a New Marker: From Area under the ROC Curve to Reclassification and beyond","volume":"27","author":"Pencina","year":"2008","journal-title":"Stat Med"},{"key":"B41","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1002\/sim.4085","article-title":"Extensions of Net Reclassification Improvement Calculations to Measure Usefulness of New Biomarkers","volume":"30","author":"Pencina","year":"2011","journal-title":"Stat Med"},{"key":"B42","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1001\/jama.2017.12126","article-title":"Discrimination and Calibration of Clinical Prediction Models: Users' Guides to the Medical Literature","volume":"318","author":"Alba","year":"2017","journal-title":"JAMA"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1001\/jama.2015.11082","article-title":"Evaluating Discrimination of Risk Prediction Models: The C Statistic","volume":"314","author":"Pencina","year":"2015","journal-title":"JAMA"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1080\/10543406.2011.607749","article-title":"Resampling Methods for Model Fitting and Model Selection","volume":"21","author":"Babu","year":"2011","journal-title":"J Biopharm Stat"},{"key":"B45","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/bmt.2012.244","article-title":"Investigation of the Freely Available Easy-To-Use Software 'EZR' for Medical Statistics","volume":"48","author":"Kanda","year":"2013","journal-title":"Bone Marrow Transpl"},{"key":"B46","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1111\/1744-9987.12352","article-title":"Evaluation of Parathyroidectomy for Secondary and Tertiary Hyperparathyroidism by the Parathyroid Surgeons' Society of Japan","volume":"20","author":"Tominaga","year":"2016","journal-title":"Ther Apher Dial"},{"key":"B47","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1093\/ndt\/gfh541","article-title":"Duration of End-Stage Renal Disease and Kidney Transplant Outcome","volume":"20","author":"Goldfarb-Rumyantzev","year":"2005","journal-title":"Nephrol Dial Transpl"},{"key":"B48","doi-asserted-by":"publisher","first-page":"17614","DOI":"10.1038\/s41598-022-20003-2","article-title":"Effect of Pretransplant Dialysis Vintage on Clinical Outcomes in Deceased Donor Kidney Transplant","volume":"12","author":"Lim","year":"2022","journal-title":"Sci Rep"},{"key":"B49","doi-asserted-by":"publisher","first-page":"704970","DOI":"10.3389\/fmed.2021.704970","article-title":"Personalized Prediction of Short- and Long-Term PTH Changes in Maintenance Hemodialysis Patients","volume":"8","author":"Pirklbauer","year":"2021","journal-title":"Front Med (Lausanne)"},{"key":"B50","doi-asserted-by":"publisher","first-page":"14634","DOI":"10.1038\/s41598-019-51265-y","article-title":"Pre-Operative Localisation of the Parathyroid Glands in Secondary Hyperparathyroidism: A Retrospective Cohort Study","volume":"9","author":"Hiramitsu","year":"2019","journal-title":"Sci Rep"}],"container-title":["Transplant International"],"original-title":[],"link":[{"URL":"https:\/\/www.frontierspartnerships.org\/articles\/10.3389\/ti.2024.12704\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T14:58:27Z","timestamp":1714575507000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontierspartnerships.org\/articles\/10.3389\/ti.2024.12704\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,1]]},"references-count":50,"alternative-id":["10.3389\/ti.2024.12704"],"URL":"https:\/\/doi.org\/10.3389\/ti.2024.12704","relation":{},"ISSN":["1432-2277"],"issn-type":[{"value":"1432-2277","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,1]]},"article-number":"12704"}}