{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:54:04Z","timestamp":1791561244911,"version":"4.3.4"},"reference-count":13,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T00:00:00Z","timestamp":1720656000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontierspartnerships.org"],"crossmark-restriction":true},"short-container-title":["Transpl Int"],"abstract":"<jats:p>There is a need to reconsider the acceptance of organs from donors considered suboptimal, in the absence of data. Toxoplasma antibody-positive donors (TPD) constitute one such group. The objective of our study was to compare graft survival in deceased donor renal transplant (Tx) recipients, stratified by Toxoplasma IgG status, using the Organ Procurement and Transplantation Network (OPTN) database. A log-linear event history regression model for graft failure categorized by Toxoplasma IgG status, adjusting for confounders was applied to first kidney-only Tx recipients from 2018 to 2022. Of the 51,422 Tx, 4,317 (8.4%) were from TPD. Acute rejection and graft failure (5% each) were similar between groups. Crude graft failure was 7.3 failures per 100 person-years for TPD recipients compared to 6.5 failures per 100 person-years for the Toxoplasma-negative group (<jats:italic>p<\/jats:italic> 0.008). The crude failure rate ratio was 1.14 with an adjusted hazard rate ratio of 1.04 (95% CI: 0.94, 1.15, <jats:italic>p<\/jats:italic> 0.39). In renal Tx recipients, TPD graft recipients have comparable survival to Tx from Toxoplasma-negative recipients. While caution and close monitoring of recipients post-Tx for surveillance of disseminated toxoplasmosis are still warranted, our study suggests that patients can be successfully managed using TPD organs.<\/jats:p>","DOI":"10.3389\/ti.2024.13203","type":"journal-article","created":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T04:11:17Z","timestamp":1720671077000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Outcomes of Kidney Transplants From Toxoplasma-Positive Donors: An Organ Procurement and Transplant Network Database Analysis"],"prefix":"10.3389","volume":"37","author":[{"given":"Lavjay","family":"Butani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Tancredi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,7,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1097\/TP.0000000000004801","article-title":"Kidney Donation After Circulatory Death Using Thoracoabdominal Normothermic Regional Perfusion: The Largest Report of the United States Experience","volume":"108","author":"Zhou","year":"2023","journal-title":"Transplantation"},{"key":"B2","doi-asserted-by":"publisher","first-page":"e15115","DOI":"10.1111\/ctr.15115","article-title":"Single Center Experience and Literature Review of Kidney Transplantation From Non-Ideal Donors With Acute Kidney Injury: Risk and Reward","volume":"37","author":"Webb","year":"2023","journal-title":"Clin Transpl"},{"key":"B3","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/s0140-6736(83)92553-9","article-title":"Toxoplasmosis and Heart Transplantation","volume":"2","author":"Nagington","year":"1983","journal-title":"Lancet."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.3390\/pathogens10111351","article-title":"Comprehensive Overview of Toxoplasma Gondii-Induced and Associated Diseases","volume":"10","author":"Daher","year":"2021","journal-title":"Pathogens"},{"key":"B5","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1093\/aje\/154.4.357","article-title":"Toxoplasma Gondii Infection in the United States: Seroprevalence and Risk Factors","volume":"154","author":"Jones","year":"2001","journal-title":"Am J Epidemiol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1093\/cid\/cir806","article-title":"Risk Factors, Clinical Features, and Outcomes of Toxoplasmosis in Solid-Organ Transplant Recipients: A Matched Case-Control Study","volume":"54","author":"Fernandez-Sabe","year":"2012","journal-title":"Clin Infect Dis"},{"key":"B7","doi-asserted-by":"publisher","first-page":"102175","DOI":"10.1016\/j.parint.2020.102175","article-title":"Seroprevalence of Toxoplasma Gondii in the U.S.: Evidence From a Representative Cross-Sectional Survey","volume":"79","author":"Owusu-Dommey","year":"2020","journal-title":"Parasitol Int"},{"key":"B8","doi-asserted-by":"publisher","first-page":"889","DOI":"10.15585\/mmwr.mm7128a1","article-title":"Public Health Surveillance and Reporting for Human Toxoplasmosis - Six States, 2021","volume":"71","author":"McCall","year":"2022","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"B9","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1097\/TP.0b013e318169bebd","article-title":"The Use of Donor and Recipient Screening for Toxoplasma in the Era of Universal Trimethoprim Sulfamethoxazole Prophylaxis","volume":"85","author":"Gourishankar","year":"2008","journal-title":"Transplantation"},{"key":"B10","doi-asserted-by":"publisher","first-page":"e13636","DOI":"10.1111\/tid.13636","article-title":"Clinical Characteristics and Outcomes of Toxoplasmosis Among Transplant Recipients at Two US Academic Medical Centers","volume":"23","author":"Adekunle","year":"2021","journal-title":"Transpl Infect Dis"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.3201\/eid2408.180045","article-title":"Toxoplasmosis in Transplant Recipients, Europe, 2010-2014","volume":"24","author":"Robert-Gangneux","year":"2018","journal-title":"Emerg Infect Dis"},{"key":"B12","doi-asserted-by":"publisher","first-page":"e13139","DOI":"10.1111\/tid.13139","article-title":"Toxoplasma Infection in Kidney Donors and Transplant Recipients from Western Mexico: A One-Year Follow-Up","volume":"21","author":"Galvan-Ramirez","year":"2019","journal-title":"Transpl Infect Dis"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1097\/TP.0b013e3182a9274a","article-title":"Toxoplasma Gondii Serostatus Is Not Associated With Impaired Long-Term Survival after Heart Transplantation","volume":"96","author":"van Hellemond","year":"2013","journal-title":"Transplantation"}],"container-title":["Transplant International"],"original-title":[],"link":[{"URL":"https:\/\/www.frontierspartnerships.org\/articles\/10.3389\/ti.2024.13203\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T04:11:21Z","timestamp":1720671081000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontierspartnerships.org\/articles\/10.3389\/ti.2024.13203\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,11]]},"references-count":13,"alternative-id":["10.3389\/ti.2024.13203"],"URL":"https:\/\/doi.org\/10.3389\/ti.2024.13203","relation":{},"ISSN":["1432-2277"],"issn-type":[{"value":"1432-2277","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,11]]},"article-number":"13203"}}