{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T22:12:04Z","timestamp":1780611124082,"version":"3.54.1"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:00Z","timestamp":1752105600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontierspartnerships.org"],"crossmark-restriction":true},"short-container-title":["Transpl. Int."],"abstract":"<jats:p>Liver transplantation (LT) is curative for end stage liver disease. Expanding LT indications with limited deceased donor grafts has created organ shortages. Living donor liver transplant (LDLT) increases available organs. In 2019, we restarted our adult LDLT program. We describe our steps to create a successful LDLT program, and our outcomes. Critical steps of program development included market analysis, creation of protocols based on best care practices and a rigorous education program. Patients and donors were then actively recruited for LDLT. Outcomes were measured as morbidity (\u22653 on the Clavien-Dindo grading system) and mortality. Between January 2019 and August 2024, 54 LDLT were performed. 2 (3%) donors experienced grade 3A and 7 (12%) donors experience grade 3B complications. There was no donor mortality. 22 (41%) patients were transplanted for PSC, the average MELD score was 13 (6\u201332). 35 (65%) patients had Roux-en-Y reconstructions. 25 (46%) complications were experienced in 22 (40%) patients, there were 2 recipient deaths. Patient and graft survival after LDLT was 97% and 97%, respectively. This paper reported the successful establishment of a LDLT program in the Netherlands. Establishing a LDLT program brings its own unique challenges, with careful planning and persistence, these challenges can be overcome.<\/jats:p>","DOI":"10.3389\/ti.2025.14442","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T05:10:16Z","timestamp":1752124216000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Developing an Adult Living Donor Liver Transplant Program in Western Europe: The Rotterdam Experience"],"prefix":"10.3389","volume":"38","author":[{"given":"Alicia Jane","family":"Chorley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech G.","family":"Polak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khe C. K.","family":"Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Turkan","family":"Terkivatan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Kissler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michail","family":"Doukas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Den Hoed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten G.","family":"Thomeer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy","family":"Dwarkasing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herold","family":"Metselaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan N. M.","family":"Ijzermans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Porte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernst Johan","family":"Kuipers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Minnee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Boehnert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,7,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"118","DOI":"10.3978\/j.issn.2304-3881.2015.07.03","article-title":"Right Lobe Living-Donor Hepatectomy-the Toronto Approach, Tips and Tricks","volume":"5","author":"Sapisochin","year":"2016","journal-title":"Hepatobiliary Surg Nutr"},{"key":"B2","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.gtc.2018.01.001","article-title":"Living Donor Liver Transplantation: Technical Innovations","volume":"47","author":"Tulla","year":"2018","journal-title":"Gastroenterol Clin North Am"},{"key":"B3","doi-asserted-by":"publisher","first-page":"S64","DOI":"10.1053\/jlts.2000.19015","article-title":"Living Donor Liver Transplantation in Adults: Outcome in Europe","volume":"6","author":"Broelsch","year":"2000","journal-title":"Liver Transpl"},{"key":"B4","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1002\/lt.24151","article-title":"The Travails of Setting up a Living Donor Liver Transplant Program: Experience from Pakistan and Lessons Learned","volume":"21","author":"Dar","year":"2015","journal-title":"Liver Transpl"},{"key":"B5","doi-asserted-by":"publisher","first-page":"145","DOI":"10.3978\/j.issn.2304-3881.2015.08.03","article-title":"Living Donor Liver Transplantation in Taiwan-Challenges beyond Surgery","volume":"5","author":"Pillai","year":"2016","journal-title":"Hepatobiliary Surg Nutr"},{"key":"B6","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1016\/j.transproceed.2011.01.094","article-title":"Applicability of Living Donor Liver Transplantation in a Program of Adult Liver Transplantation","volume":"43","author":"Herrero","year":"2011","journal-title":"Transpl Proc"},{"key":"B7","doi-asserted-by":"publisher","first-page":"15","DOI":"10.3748\/wjg.14.15","article-title":"Historical Perspective of Living Donor Liver Transplantation","volume":"14","author":"Chan","year":"2008","journal-title":"World J Gastroenterol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"159","DOI":"10.3978\/j.issn.2304-3881.2015.10.04","article-title":"Living Donor Liver Transplantation in Europe","volume":"5","author":"Nadalin","year":"2016","journal-title":"Hepatobiliary Surg Nutr"},{"key":"B9","doi-asserted-by":"publisher","first-page":"iv16","DOI":"10.1093\/ndt\/gfh1036","article-title":"Living-Donor Liver Transplantation--European Experiences","volume":"19","author":"Settmacher","year":"2004","journal-title":"Nephrol Dial Transpl"},{"key":"B10","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1007\/s00595-017-1468-z","article-title":"The Donor Advocacy Team: A Risk Management Program for Living Organ, Tissue, and Cell Transplant Donors","volume":"47","author":"Eguchi","year":"2017","journal-title":"Surg Today"},{"key":"B11","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1097\/TP.0000000000001571","article-title":"The International Liver Transplantation Society Living Donor Liver Transplant Recipient Guideline","volume":"101","author":"Miller","year":"2017","journal-title":"Transplantation"},{"key":"B12","unstructured":"Protocol indicatie en selectie voor levertransplantatie bij volwassenen en kinderen in Nederland: Nederlandse Transplantatie Vereniging 2022\n          \n          \n            \n              Vereniging\n              NT"},{"key":"B13","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1097\/SLA.0b013e3181b13ca2","article-title":"The Clavien-Dindo Classification of Surgical Complications: Five-Year Experience","volume":"250","author":"Clavien","year":"2009","journal-title":"Ann Surg"},{"key":"B14","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1007\/s00595-015-1236-x","article-title":"Extended Clavien-Dindo Classification of Surgical Complications: Japan Clinical Oncology Group Postoperative Complications Criteria","volume":"46","author":"Katayama","year":"2016","journal-title":"Surg Today"},{"key":"B15","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1111\/j.1464-410X.2011.10889.x","article-title":"Impact of Comorbidity on Complications after Nephrectomy: Use of the Clavien Classification of Surgical Complications","volume":"110","author":"Hennus","year":"2012","journal-title":"BJU Int"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1002\/lt.26220","article-title":"Can Living Donor Liver Transplantation in the United States Reach its Potential?","volume":"27","author":"Kaplan","year":"2021","journal-title":"Liver Transpl"},{"key":"B17","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1002\/lt.24651","article-title":"Donor Safety in Living Donor Liver Donation: An Italian Multicenter Survey","volume":"23","author":"Lauterio","year":"2017","journal-title":"Liver Transpl"},{"key":"B18","doi-asserted-by":"publisher","first-page":"e14610","DOI":"10.1111\/ctr.14610","article-title":"Surgical Complications after Living and Deceased Donor Liver Transplant: The NSQIP Transplant Experience","volume":"36","author":"Amara","year":"2022","journal-title":"Clin Transpl"},{"key":"B19","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1097\/MOT.0000000000000280","article-title":"Fostering Liver Living Donor Liver Transplantation","volume":"21","author":"Levy","year":"2016","journal-title":"Curr Opin Organ Transpl"},{"key":"B20","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.cld.2020.08.011","article-title":"Expanding Donor Selection and Recipient Indications for Living Donor Liver Transplantation","volume":"25","author":"Moghe","year":"2021","journal-title":"Clin Liver Dis"},{"key":"B21","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1001\/jamasurg.2022.3327","article-title":"Survival Benefit of Living-Donor Liver Transplant","volume":"157","author":"Jackson","year":"2022","journal-title":"JAMA Surg"},{"key":"B22","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1111\/ajt.16864","article-title":"Long-Term Outcome after Living Donor Liver Transplantation Compared to Donation after Brain Death in Autoimmune Liver Diseases: Experience from the European Liver Transplant Registry","volume":"22","author":"Heinemann","year":"2022","journal-title":"Am J Transpl"},{"key":"B23","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.ijsu.2020.04.069","article-title":"Biliary Reconstruction and Complications in Living Donor Liver Transplantation","author":"Jung","year":"2020","journal-title":"Int J Surg"}],"container-title":["Transplant International"],"original-title":[],"link":[{"URL":"https:\/\/www.frontierspartnerships.org\/articles\/10.3389\/ti.2025.14442\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T05:10:18Z","timestamp":1752124218000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontierspartnerships.org\/articles\/10.3389\/ti.2025.14442\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,10]]},"references-count":23,"alternative-id":["10.3389\/ti.2025.14442"],"URL":"https:\/\/doi.org\/10.3389\/ti.2025.14442","relation":{},"ISSN":["1432-2277"],"issn-type":[{"value":"1432-2277","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,10]]},"article-number":"14442"}}