{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T22:53:52Z","timestamp":1782773632143,"version":"3.54.5"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontierspartnerships.org"],"crossmark-restriction":true},"short-container-title":["Transpl. Int."],"abstract":"<jats:p>Mixed hepatocellular carcinoma (HCC) with cholangiocarcinoma (HCC-CCA) is an aggressive primary liver cancer and difficult to distinguish from HCC using non-invasive methods. Outcomes of patients incidentally diagnosed with HCC-CCA after LT relative to pure HCC with similar tumor burden were investigated. Medical records of patients undergoing LT (n = 1,898) for HCC (n = 493) from 6\/2008\u20139\/2023 were reviewed. Patients incidentally diagnosed with HCC-CCA were propensity matched to HCC patients undergoing LT. Independent analyses were performed using pre-LT (Match1; identifiable pre-LT) and explant pathology (Match2, more prognostic) characteristics. Incidental HCC-CCA occurred in 19 (3.9%) patients; all assumed to have HCC pre-LT and received HCC-directed neoadjuvant treatment. When matched on pre-LT characteristics (Match1, n = 57), more patients with HCC-CCA were outside Milan or University of California, San Francisco criteria on explant (p = 0.01). More patients with HCC-CCA underwent neoadjuvant microwave ablation (p = 0.02) compared to HCC Match2 (n = 45) but were otherwise similar demographically and clinically. Overall and recurrence-free survival were lower for HCC-CCA in Match1 (p = 0.003 and p &amp;lt; 0.001, respectively) and Match2 (p &amp;lt; 0.001 and p = 0.001, respectively). HCC-CCA has an aggressive phenotype with high recurrence after LT. Better screening tools and biomarkers are needed to distinguish HCC-CCA from HCC to ensure patients receive appropriate treatment and maximize post-LT outcomes.<\/jats:p>","DOI":"10.3389\/ti.2025.15298","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T06:10:06Z","timestamp":1769580606000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Incidental Combined Hepatocellular-Cholangiocarcinoma in Liver Transplant Recipients: A Matched Cohort Study"],"prefix":"10.3389","volume":"38","author":[{"given":"Sudha","family":"Kodali","sequence":"first","affiliation":[{"name":"Sherrie and Alan Conover Center for Liver Disease and Transplantation, Houston Methodist Hospital","place":["Houston, TX, United States"]},{"name":"JC Walter Jr Transplant Center, Houston Methodist Hospital","place":["Houston, TX, United States"]},{"name":"Department of Medicine, Houston Methodist Hospital","place":["Houston, TX, United States"]},{"name":"Department of Medicine, Weill Cornell Medical College","place":["New York, NY, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashton A.","family":"Connor","sequence":"additional","affiliation":[{"name":"Sherrie and Alan Conover Center for Liver Disease and Transplantation, Houston Methodist Hospital","place":["Houston, TX, United States"]},{"name":"JC Walter Jr Transplant Center, Houston Methodist Hospital","place":["Houston, TX, United States"]},{"name":"Department of Surgery, Houston Methodist Hospital","place":["Houston, TX, United States"]},{"name":"Department of Surgery, Weill Cornell Medical College","place":["New York, NY, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"David W.","family":"Victor","sequence":"additional","affiliation":[{"name":"Sherrie and Alan Conover Center for Liver Disease and Transplantation, Houston Methodist Hospital","place":["Houston, TX, United States"]},{"name":"JC Walter Jr Transplant Center, Houston Methodist Hospital","place":["Houston, TX, United States"]},{"name":"Department of Medicine, Houston Methodist Hospital","place":["Houston, TX, United States"]},{"name":"Department of Medicine, Weill Cornell Medical College","place":["New York, NY, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maen","family":"Abdelrahim","sequence":"additional","affiliation":[{"name":"JC Walter Jr Transplant Center, Houston Methodist Hospital","place":["Houston, TX, United States"]},{"name":"Department of Medicine, Houston Methodist Hospital","place":["Houston, TX, United States"]},{"name":"Department of Medicine, Weill Cornell Medical College","place":["New York, NY, United States"]},{"name":"Department of Oncology, Neal Cancer Center, Houston Methodist Hospital","place":["Houston, TX, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Elaileh","sequence":"additional","affiliation":[{"name":"Department of Surgery, Houston Methodist Hospital","place":["Houston, TX, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khush","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Surgery, Houston Methodist Hospital","place":["Houston, TX, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth W.","family":"Brombosz","sequence":"additional","affiliation":[{"name":"Department of Surgery, Houston Methodist Hospital","place":["Houston, TX, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward A.","family":"Graviss","sequence":"additional","affiliation":[{"name":"Department of Surgery, Houston Methodist Hospital","place":["Houston, TX, United States"]},{"name":"Department of Surgery, Weill Cornell Medical College","place":["New York, NY, United States"]},{"name":"Department of Pathology and Genomic Medicine, Houston Methodist Hospital","place":["Houston, TX, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duc T.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Baylor College of Medicine","place":["Houston, TX, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Medicine, Weill Cornell Medical College","place":["New York, NY, United States"]},{"name":"Center for Health Data Science and Analytics, Houston Methodist Hospital","place":["Houston, TX, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda W.","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Surgery, Houston Methodist Hospital","place":["Houston, TX, United States"]},{"name":"Department of Surgery, Weill Cornell Medical College","place":["New York, NY, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary R.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Pathology and Genomic Medicine, Houston Methodist Hospital","place":["Houston, TX, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadhna","family":"Dhingra","sequence":"additional","affiliation":[{"name":"Department of Pathology and Genomic Medicine, Houston Methodist Hospital","place":["Houston, TX, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamneet","family":"Basra","sequence":"additional","affiliation":[{"name":"Sherrie and Alan Conover Center for Liver Disease and Transplantation, Houston Methodist Hospital","place":["Houston, TX, United States"]},{"name":"JC Walter Jr Transplant Center, Houston Methodist Hospital","place":["Houston, TX, United States"]},{"name":"Department of Medicine, Houston Methodist Hospital","place":["Houston, TX, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle R.","family":"Jones-Pauley","sequence":"additional","affiliation":[{"name":"Sherrie and Alan Conover Center for Liver Disease and Transplantation, Houston Methodist Hospital","place":["Houston, TX, United States"]},{"name":"JC Walter Jr Transplant Center, Houston Methodist Hospital","place":["Houston, TX, United States"]},{"name":"Department of Medicine, Houston Methodist Hospital","place":["Houston, TX, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazen","family":"Noureddin","sequence":"additional","affiliation":[{"name":"Sherrie and Alan Conover Center for Liver Disease and Transplantation, Houston Methodist Hospital","place":["Houston, TX, United States"]},{"name":"JC Walter Jr Transplant Center, Houston Methodist Hospital","place":["Houston, TX, United States"]},{"name":"Department of Medicine, Houston Methodist Hospital","place":["Houston, TX, United States"]},{"name":"Houston Research Institute","place":["Houston, TX, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constance M.","family":"Mobley","sequence":"additional","affiliation":[{"name":"Sherrie and Alan Conover Center for Liver Disease and Transplantation, Houston Methodist Hospital","place":["Houston, TX, United States"]},{"name":"JC Walter Jr Transplant Center, Houston Methodist Hospital","place":["Houston, TX, United States"]},{"name":"Department of Surgery, Houston Methodist Hospital","place":["Houston, TX, United States"]},{"name":"Department of Surgery, Weill Cornell Medical College","place":["New York, NY, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Hobeika","sequence":"additional","affiliation":[{"name":"Sherrie and Alan Conover Center for Liver Disease and Transplantation, Houston Methodist Hospital","place":["Houston, TX, United States"]},{"name":"JC Walter Jr Transplant Center, Houston Methodist Hospital","place":["Houston, TX, United States"]},{"name":"Department of Surgery, Houston Methodist Hospital","place":["Houston, TX, United States"]},{"name":"Department of Surgery, Weill Cornell Medical College","place":["New York, NY, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline J.","family":"Simon","sequence":"additional","affiliation":[{"name":"Sherrie and Alan Conover Center for Liver Disease and Transplantation, Houston Methodist Hospital","place":["Houston, TX, United States"]},{"name":"JC Walter Jr Transplant Center, Houston Methodist Hospital","place":["Houston, TX, United States"]},{"name":"Department of Surgery, Houston Methodist Hospital","place":["Houston, TX, United States"]},{"name":"Department of Surgery, Weill Cornell Medical College","place":["New York, NY, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yee","family":"Lee Cheah","sequence":"additional","affiliation":[{"name":"Sherrie and Alan Conover Center for Liver Disease and Transplantation, Houston Methodist Hospital","place":["Houston, TX, United States"]},{"name":"JC Walter Jr Transplant Center, Houston Methodist Hospital","place":["Houston, TX, United States"]},{"name":"Department of Surgery, Houston Methodist Hospital","place":["Houston, TX, United States"]},{"name":"Department of Surgery, Weill Cornell Medical College","place":["New York, NY, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirk","family":"Heyne","sequence":"additional","affiliation":[{"name":"JC Walter Jr Transplant Center, Houston Methodist Hospital","place":["Houston, TX, United States"]},{"name":"Department of Medicine, Houston Methodist Hospital","place":["Houston, TX, United States"]},{"name":"Department of Medicine, Weill Cornell Medical College","place":["New York, NY, United States"]},{"name":"Department of Oncology, Neal Cancer Center, Houston Methodist Hospital","place":["Houston, TX, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed O.","family":"Kaseb","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Medical Oncology, Division of Cancer Medicine, University of Texas MD Anderson Cancer Center","place":["Houston, TX, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Saharia","sequence":"additional","affiliation":[{"name":"Sherrie and Alan Conover Center for Liver Disease and Transplantation, Houston Methodist Hospital","place":["Houston, TX, United States"]},{"name":"JC Walter Jr Transplant Center, Houston Methodist Hospital","place":["Houston, TX, United States"]},{"name":"Department of Surgery, Houston Methodist Hospital","place":["Houston, TX, United States"]},{"name":"Department of Surgery, Weill Cornell Medical College","place":["New York, NY, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Osama","family":"Gaber","sequence":"additional","affiliation":[{"name":"Sherrie and Alan Conover Center for Liver Disease and Transplantation, Houston Methodist Hospital","place":["Houston, TX, United States"]},{"name":"JC Walter Jr Transplant Center, Houston Methodist Hospital","place":["Houston, TX, United States"]},{"name":"Department of Surgery, Houston Methodist Hospital","place":["Houston, TX, United States"]},{"name":"Department of Surgery, Weill Cornell Medical College","place":["New York, NY, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Mark","family":"Ghobrial","sequence":"additional","affiliation":[{"name":"Sherrie and Alan Conover Center for Liver Disease and Transplantation, Houston Methodist Hospital","place":["Houston, TX, United States"]},{"name":"JC Walter Jr Transplant Center, Houston Methodist Hospital","place":["Houston, TX, United States"]},{"name":"Department of Surgery, Houston Methodist Hospital","place":["Houston, TX, United States"]},{"name":"Department of Surgery, Weill Cornell Medical College","place":["New York, NY, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global Cancer Statistics 2018: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J Clin"},{"key":"B2","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/j.hbpd.2020.07.004","article-title":"Combined Hepatocellular-Cholangiocarcinoma: An Update on Epidemiology, Classification, Diagnosis and Management","volume":"19","author":"Schizas","year":"2020","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"B3","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1002\/jso.25331","article-title":"Management and Outcomes Among Patients with Mixed Hepatocholangiocellular Carcinoma: A Population-Based Analysis","volume":"119","author":"Spolverato","year":"2019","journal-title":"J Surg Oncol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"e1774","DOI":"10.1002\/onco.13893","article-title":"Long-Term Survival of Combined Hepatocellular-Cholangiocarcinoma: A Nationwide Study","volume":"26","author":"Chen","year":"2021","journal-title":"Oncologist"},{"key":"B5","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.surg.2023.09.040","article-title":"Combined Hepatocellular-Cholangiocarcinoma Compared to Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma: Different Survival, Similar Recurrence: Report of a Large Study on Repurposed Databases with Propensity Score Matching","volume":"175","author":"Amory","year":"2024","journal-title":"Surgery"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1097\/tp.0000000000003212","article-title":"Liver Transplantation for Cholangiocarcinoma and Mixed Hepatocellular Cholangiocarcinoma: Working Group Report from the ILTS Transplant Oncology Consensus Conference","volume":"104","author":"Sapisochin","year":"2020","journal-title":"Transplantation"},{"key":"B7","doi-asserted-by":"publisher","first-page":"e20945","DOI":"10.1016\/j.heliyon.2023.e20945","article-title":"Liver Transplantation Versus Resection for Patients with Combined Hepatocellular Cholangiocarcinoma: A Retrospective Cohort Study","volume":"9","author":"Mi","year":"2023","journal-title":"Heliyon"},{"key":"B8","doi-asserted-by":"publisher","first-page":"21","DOI":"10.21037\/atm-21-5391","article-title":"Promising Role of Liver Transplantation in Patients with Combined Hepatocellular-Cholangiocarcinoma: A Propensity Score Matching Analysis","volume":"10","author":"Chen","year":"2022","journal-title":"Ann Transl Med"},{"key":"B9","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.jamcollsurg.2020.11.017","article-title":"Multi-Center Analysis of Liver Transplantation for Combined Hepatocellular Carcinoma-Cholangiocarcinoma Liver Tumors","volume":"232","author":"Dageforde","year":"2021","journal-title":"J Am Coll Surg"},{"key":"B10","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1002\/lt.25737","article-title":"Analysis of Liver Resection Versus Liver Transplantation on Outcome of Small Intrahepatic Cholangiocarcinoma and Combined Hepatocellular-Cholangiocarcinoma in the Setting of Cirrhosis","volume":"26","author":"De Martin","year":"2020","journal-title":"Liver Transpl"},{"key":"B11","doi-asserted-by":"publisher","first-page":"639","DOI":"10.3390\/cancers15030639","article-title":"Mixed Hepatocellular Cholangiocarcinoma: A Comparison of Survival Between Mixed Tumors, Intrahepatic Cholangiocarcinoma and Hepatocellular Carcinoma from a Single Center","volume":"15","author":"Penzkofer","year":"2023","journal-title":"Cancers (Basel)"},{"key":"B12","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1016\/j.cireng.2023.04.010","article-title":"Long-Term Follow-Up of Liver Transplantation in Incidental Intrahepatic Cholangiocarcinoma and Mixed Hepatocellular-Cholangiocarcinoma","volume":"101","author":"Garcia-Moreno","year":"2023","journal-title":"Cir Esp Engl Ed"},{"key":"B13","doi-asserted-by":"publisher","first-page":"97","DOI":"10.14744\/hf.2022.2022.0037","article-title":"Incidental Combined Hepatocellular-Cholangiocarcinoma in Liver Transplant Patients: Does It Have a Worse Prognosis?","volume":"4","author":"Anilir","year":"2023","journal-title":"Hepatol Forum"},{"key":"B14","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1001\/jamaoncol.2016.5116","article-title":"Validation of a Risk Estimation of Tumor Recurrence After Transplant (RETREAT) Score for Hepatocellular Carcinoma Recurrence After Liver Transplant","volume":"3","author":"Mehta","year":"2017","journal-title":"JAMA Oncol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.trre.2021.100676","article-title":"Predictors of Post-Recurrence Survival in Hepatocellular Carcinoma Patients Following Liver Transplantation: Systematic Review and Meta-Analysis","volume":"36","author":"Al-Ameri","year":"2022","journal-title":"Transplant Rev"},{"key":"B16","first-page":"527","article-title":"Meta-Analysis of Tumor Recurrence After Liver Transplantation for Hepatocellular Carcinoma Based on 1,198 Cases","volume":"12","author":"Sotiropoulos","year":"2007","journal-title":"Eur J Med Res"},{"key":"B17","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1111\/ajt.16906","article-title":"Survival Following Liver Transplantation for Locally Advanced, Unresectable Intrahepatic Cholangiocarcinoma","volume":"22","author":"McMillan","year":"2022","journal-title":"Am J Transpl"},{"key":"B18","doi-asserted-by":"publisher","first-page":"379","DOI":"10.4103\/jcrt.JCRT_403_19","article-title":"Microwave Ablation Versus Other Interventions for Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis","volume":"16","author":"Cui","year":"2020","journal-title":"J Cancer Res Ther"},{"key":"B19","doi-asserted-by":"publisher","first-page":"760","DOI":"10.21037\/qims-24-607","article-title":"Efficacy of Microwave Ablation for Intrahepatic Cholangiocarcinoma: A Systematic Review and Meta-Analysis","volume":"15","author":"Song","year":"2025","journal-title":"Quant Imaging Med Surg"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1016\/j.jvir.2022.05.019","article-title":"Microwave Ablation as Bridging to Liver Transplant for Patients with Hepatocellular Carcinoma: A Single-Center Retrospective Analysis","volume":"33","author":"Couillard","year":"2022","journal-title":"J Vasc Interv Radiol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1007\/s00270-021-02873-7","article-title":"Microwave Ablation as Bridging Therapy for Patients with Hepatocellular Carcinoma Awaiting Liver Transplant: A Single Center Experience","volume":"44","author":"Som","year":"2021","journal-title":"Cardiovasc Intervent Radiol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1007\/s11547-024-01830-x","article-title":"Combined Transarterial Chemoembolization and Thermal Ablation in Candidates to Liver Transplantation with Hepatocellular Carcinoma: Pathological Findings and Post-Transplant Outcome","volume":"129","author":"Fronda","year":"2024","journal-title":"Radiol Med"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.1002\/lt.25058","article-title":"Propensity-Matched Analysis of Patients with Mixed Hepatocellular-Cholangiocarcinoma and Hepatocellular Carcinoma Undergoing Liver Transplantation","volume":"24","author":"Lunsford","year":"2018","journal-title":"Liver Transpl"},{"key":"B24","doi-asserted-by":"publisher","first-page":"e14094","DOI":"10.1111\/ctr.14094","article-title":"Liver Transplantation for Combined Hepatocellular-Cholangiocarcinoma: Outcomes and Prognostic Factors for Mortality. A Multicenter Analysis","volume":"35","author":"Jaradat","year":"2021","journal-title":"Clin Transpl"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.4240\/wjgs.v15.i7.1340","article-title":"Liver Transplantation for Combined Hepatocellular Carcinoma and Cholangiocarcinoma: A Multicenter Study","volume":"15","author":"Kim","year":"2023","journal-title":"World J Gastrointest Surg"},{"key":"B26","doi-asserted-by":"publisher","first-page":"688","DOI":"10.5306\/wjco.v13.i8.688","article-title":"Propensity-Matched Analysis of Patients with Intrahepatic Cholangiocarcinoma or Mixed Hepatocellular-Cholangiocarcinoma and Hepatocellular Carcinoma Undergoing a Liver Transplant","volume":"13","author":"Brand\u00e3o","year":"2022","journal-title":"World J Clin Oncol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1002\/lt.22307","article-title":"Mixed Hepatocellular Cholangiocarcinoma and Intrahepatic Cholangiocarcinoma in Patients Undergoing Transplantation for Hepatocellular Carcinoma","volume":"17","author":"Sapisochin","year":"2011","journal-title":"Liver Transpl"},{"key":"B28","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1097\/tp.0000000000002835","article-title":"Outcomes of Liver Transplantation for Hepatocellular Carcinoma Beyond the University of California San Francisco Criteria: A Single-Center Experience","volume":"104","author":"Victor","year":"2020","journal-title":"Transplantation"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1016\/j.jhep.2021.01.035","article-title":"Combined Hepatocellular-Cholangiocarcinoma: An Update","volume":"74","author":"Beaufr\u00e8re","year":"2021","journal-title":"J Hepatol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"87","DOI":"10.21037\/tgh.2017.10.01","article-title":"Perfusion Machines and Hepatocellular Carcinoma: A Good Match Between a Marginal Organ and an Advanced Disease?","volume":"2","author":"Ghinolfi","year":"2017","journal-title":"Transl Gastroenterol Hepatol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"13520","DOI":"10.1038\/s41598-021-92976-5","article-title":"Liver Transplantation for Hepatocellular Carcinoma Using Grafts from Uncontrolled Circulatory Death Donation","volume":"11","author":"Nutu","year":"2021","journal-title":"Sci Rep"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1948","DOI":"10.1111\/tri.13950","article-title":"Advanced Donor Age Does Not Increase Risk of Hepatocellular Carcinoma Recurrence After Liver Transplantation: A Retrospective Two-Centre Analysis Using Competing Risk Analysis","volume":"34","author":"Cusumano","year":"2021","journal-title":"Transpl Int"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1692","DOI":"10.3390\/jcm8101692","article-title":"Liver Grafts with Major Extended Donor Criteria May Expand the Organ Pool for Patients with Hepatocellular Carcinoma","volume":"8","author":"Lozanovski","year":"2019","journal-title":"J Clin Med"},{"key":"B34","doi-asserted-by":"publisher","first-page":"2704","DOI":"10.1111\/ajt.13306","article-title":"The Use of Donation After Cardiac Death Allografts Does Not Increase Recurrence of Hepatocellular Carcinoma","volume":"15","author":"Croome","year":"2015","journal-title":"Am J Transpl"}],"container-title":["Transplant International"],"original-title":[],"link":[{"URL":"https:\/\/www.frontierspartnerships.org\/articles\/10.3389\/ti.2025.15298\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T04:34:25Z","timestamp":1771994065000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontierspartnerships.org\/articles\/10.3389\/ti.2025.15298\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,28]]},"references-count":34,"alternative-id":["10.3389\/ti.2025.15298"],"URL":"https:\/\/doi.org\/10.3389\/ti.2025.15298","relation":{},"ISSN":["1432-2277"],"issn-type":[{"value":"1432-2277","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,28]]},"article-number":"15298"}}