{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T02:15:41Z","timestamp":1792462541901,"version":"4.5.0"},"reference-count":41,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontierspartnerships.org"],"crossmark-restriction":true},"short-container-title":["Transpl. Int."],"abstract":"<jats:p>\n                    Glomerular filtration rate (GFR) is a crucial parameter in post-transplant follow-up (PTF). CKD-EPI 2009 creatinine-based equation remains the most used estimated GFR (eGFR) and only few data are available on the other equations, based on creatinine, cystatin C or their combination. We evaluated 10 GFR estimation equations on 242 kidney-transplant recipient patients having measured GFR (mGFR) determination (urinary clearance of\n                    <jats:sup>99m<\/jats:sup>\n                    Tc-DTPA) with simultaneous plasma enzymatic creatinine and serum cystatin C (immunoturbidimetry or immunonephelemetry) assessments. Five creatinine (MDRD 2006, CKD-EPI 2009 and 2021, EKFC 2021, KRS 2023), two cystatin C (CKD-EPI 2012, EKFC 2023) and three combined eGFR (CKD-EPI 2012 and 2021, combined EKFC) were evaluated. All equations were significantly correlated with mGFR (R\u00b2 = 0.672\u20130.745) with a low median bias (+4.2 to \u22121.1\u00a0mL\/min\/1.73\u00a0m\u00b2). Chronic kidney disease staging agreements were all above 68% (maximum: 79.3% for CKD-EPI comb 2021). Percentages of eGFR comprised in between 30% of the mGFR ranged from 85.5% to 87.6% (combined equations), from 83.1% to 84.3% (cystatin C equations) and from 75.2% to 81.4% (creatinine equations). Combined creatinine\/cystatin C eGFR equations with a P30 value greater to 85% of transplant recipients appeared closer to mGFR than cystatin C or creatinine eGFR.\n                  <\/jats:p>","DOI":"10.3389\/ti.2026.15529","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T06:10:07Z","timestamp":1770703807000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Combined Creatinine and Cystatin C Equations Improve Estimation of Glomerular Filtration Rate in Kidney Transplant Recipients"],"prefix":"10.3389","volume":"39","author":[{"given":"Etienne","family":"Mond\u00e9sert","sequence":"first","affiliation":[{"name":"Department of Biochemistry, University Hospital of Montpellier","place":["Montpellier, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Sophie","family":"Bargnoux","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University Hospital of Montpellier","place":["Montpellier, France"]},{"name":"PhyMedExp, University of Montpellier, INSERM, CNRS","place":["Montpellier, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilan","family":"Szwarc","sequence":"additional","affiliation":[{"name":"Department of Nephrology, University Hospital of Montpellier","place":["Montpellier, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moglie","family":"Le Quintrec","sequence":"additional","affiliation":[{"name":"Department of Nephrology, University Hospital of Montpellier","place":["Montpellier, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georges","family":"Mourad","sequence":"additional","affiliation":[{"name":"Department of Nephrology, University Hospital of Montpellier","place":["Montpellier, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Paul","family":"Cristol","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University Hospital of Montpellier","place":["Montpellier, France"]},{"name":"PhyMedExp, University of Montpellier, INSERM, CNRS","place":["Montpellier, France"]},{"name":"AIDER Sant\u00e9 Fondation Charles Mion","place":["Montpellier, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1111\/j.1600-6143.2009.02834.x","article-title":"KDIGO Clinical Practice Guideline for the Care of Kidney Transplant Recipients","volume":"9","year":"2009","journal-title":"Am J Transpl"},{"key":"B2","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.kint.2020.07.025","article-title":"Trajectories of Glomerular Filtration Rate and Progression to End Stage 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