{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T10:01:41Z","timestamp":1792836101258,"version":"4.5.0"},"reference-count":47,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontierspartnerships.org"],"crossmark-restriction":true},"short-container-title":["Transpl. Int."],"abstract":"<jats:p>\n                    Extended criteria donor lungs falling below the arbitrarily set PaO\n                    <jats:sub>2<\/jats:sub>\n                    \/FiO\n                    <jats:sub>2<\/jats:sub>\n                    (PFR) threshold of 300 are frequently declined despite other acceptable parameters. This two-center retrospective analysis investigates whether donor PFR is a risk factor for outcomes after lung transplantation (LuTx). A retrospective cohort analysis was conducted at University Hospitals Leuven, Belgium and Motol University Hospital, Prague, Czech Republic including adult LuTx recipients from 2010 to 2022 (Leuven) and 2018\u20133\/2023 (Prague). Primary endpoints: primary graft dysfunction (PGD) grade 3\u00a0at 24 and 72 h and 2\u2010year overall survival. Secondary endpoints: incidence of ACR and CLAD-free survival. Donor PFR was measured from an arterial blood gas sample. Logistic and Cox regression analyses were employed to assess correlations, while survival was analyzed using Kaplan-Meier estimates. A total of 984 LuTx recipients were included. Median follow-up was 4 years. Recipients were predominantly male (54%), with chronic obstructive pulmonary disease being the most common indication for transplantation. Donor characteristics included median age of 51 years, and 18% of donors were DCD. Analyses identified lower donor PFR as a risk factor for PGD grade 3\u00a0at 24 h, but not at 72 h. PFR was not associated with the incidence of ACR or with 2-year overall survival after LuTx. Donor PFR does not appear to be a risk factor for development of late PGD or for adversely impacting outcomes. However, it is associated with increased risk of early PGD.\n                  <\/jats:p>","DOI":"10.3389\/ti.2026.16414","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T05:10:10Z","timestamp":1791522610000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Lower lung donor PaO2\/FiO2 ratio correlates with early primary graft dysfunction, but does not impact overall survival after lung transplantation: a dual center study"],"prefix":"10.3389","volume":"39","author":[{"given":"Rene","family":"Novysedlak","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, University Hospitals Leuven","place":["Leuven, Belgium"]},{"name":"Prague Lung Transplant Program, 3rd Department of Surgery, First Faculty of Medicine, Charles University, Motol and Homolka University Hospital","place":["Prague, 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