{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T00:33:48Z","timestamp":1769214828705,"version":"3.49.0"},"reference-count":80,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:00:00Z","timestamp":1741219200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Bioeng. Biotechnol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The growing need for durable implants, driven by aging populations and increased trauma cases, highlights challenges such as limited osseointegration and biofilm formation. 45S5 Bioglass<jats:sup>\u00ae<\/jats:sup> has shown promise due to its bioactivity, antimicrobial properties, and ability to enhance osseointegration through electrical polarization. This study investigates the effects of incorporating different concentrations of ZrO<jats:sub>2<\/jats:sub> and Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub> into 45S5 Bioglass<jats:sup>\u00ae<\/jats:sup> to enhance its electrical and biological properties.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Raman analysis was used to evaluate how these oxides influenced the amount of non-bridging oxygens (NBOs) and glass network connectivity. Electrical characterization was performed using impedance spectroscopy to measure conductivity and ion mobility. Antibacterial activity was assessed using the agar diffusion method, and bioactivity was evaluated through simulated body fluid (SBF) immersion tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results revealed that bioglasses containing ZrO<jats:sub>2<\/jats:sub> exhibited higher NBO content compared to Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub>, leading to improved electrical and biological properties. ZrO<jats:sub>2<\/jats:sub>, particularly at 2\u00a0mol%, significantly enhanced conductivity, antibacterial activity, and bioactivity. In contrast, Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub> reduced both antibacterial activity and bioactivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The findings demonstrate that ZrO<jats:sub>2<\/jats:sub> addition improves the electrical and biological performance of 45S5 Bioglass<jats:sup>\u00ae<\/jats:sup>, making it a promising candidate for durable implants. Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub>, however, showed limited benefits.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fbioe.2025.1537856","type":"journal-article","created":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T06:52:44Z","timestamp":1741243964000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Influence of zirconium dioxide (ZrO2) and magnetite (Fe3O4) additions on the structural, electrical, and biological properties of Bioglass\u00ae for metal implant coatings"],"prefix":"10.3389","volume":"13","author":[{"given":"Imen","family":"Hammami","sequence":"first","affiliation":[]},{"given":"Manuel Pedro","family":"Fernandes Gra\u00e7a","sequence":"additional","affiliation":[]},{"given":"S\u00edlvia Rodrigues","family":"Gavinho","sequence":"additional","affiliation":[]},{"given":"Joana Soares","family":"Regadas","sequence":"additional","affiliation":[]},{"given":"Suresh Kumar","family":"Jakka","sequence":"additional","affiliation":[]},{"given":"Ana Sofia","family":"P\u00e1dua","sequence":"additional","affiliation":[]},{"given":"Jorge Carvalho","family":"Silva","sequence":"additional","affiliation":[]},{"given":"Isabel","family":"S\u00e1-Nogueira","sequence":"additional","affiliation":[]},{"given":"Jo\u00e3o Paulo","family":"Borges","sequence":"additional","affiliation":[]}],"member":"1965","published-online":{"date-parts":[[2025,3,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"50","DOI":"10.2174\/1874210601408010050","article-title":"A brief historical perspective on dental implants, their surface coatings and treatments","volume":"8","author":"Abraham","year":"2014","journal-title":"Open Dent. 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