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For nearly 50\u00a0years, current therapeutic approaches include full pancreas transplantation and isolated pancreatic islets, more recently, cell therapy such as <jats:italic>in vitro<\/jats:italic> generated islets and stem cell derived. The transplantation of pancreatic islet cells can be less invasive than full organ transplantation, however, does not achieve the same rate of functional success due to the low survival of the engrafted cells. Tissue-engineered bioartificial pancreas has been designed to address such issues, improving cell engraftment, survival, and immune rejection problems, with the added advantage that the tissue produced <jats:italic>in vitro<\/jats:italic> has an unlimited source of material.<\/jats:p>","DOI":"10.3389\/fbiom.2025.1524518","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T07:12:09Z","timestamp":1742368329000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Advancing diabetes treatment: from human beta cell technology to bioartificial pancreas development"],"prefix":"10.3389","volume":"4","author":[{"given":"Joana","family":"S\u00e1","sequence":"first","affiliation":[]},{"given":"Simone","family":"S\u00e1","sequence":"additional","affiliation":[]},{"given":"H\u00e9l\u00e8ne","family":"Lem\u00e9nager","sequence":"additional","affiliation":[]},{"given":"Raquel","family":"Costa","sequence":"additional","affiliation":[]},{"given":"Brigitte","family":"Onteniente","sequence":"additional","affiliation":[]},{"given":"Raquel","family":"Soares","sequence":"additional","affiliation":[]},{"given":"Viviana P.","family":"Ribeiro","sequence":"additional","affiliation":[]},{"given":"Ana L.","family":"Oliveira","sequence":"additional","affiliation":[]}],"member":"1965","published-online":{"date-parts":[[2025,3,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/s40472-021-00333-2","article-title":"Tissue engineering strategies for improving beta cell transplantation outcome","volume":"8","author":"Abadpour","year":"","journal-title":"TISSUE Eng. 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A.\n            \n            \n              Maniam\n              J.\n            \n          \n          \n          2022"},{"key":"B70","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/s13052-016-0273-4","article-title":"Cell therapies for pancreatic beta-cell replenishment","volume":"42","author":"Okere","year":"2016","journal-title":"Ital. J. 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