{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:45:16Z","timestamp":1777509916922,"version":"3.51.4"},"reference-count":139,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/04462\/2020"],"award-info":[{"award-number":["UIDB\/04462\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDP\/04462\/2020"],"award-info":[{"award-number":["UIDP\/04462\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["LA\/P\/0087\/2020"],"award-info":[{"award-number":["LA\/P\/0087\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PD\/BD\/128215\/2016"],"award-info":[{"award-number":["PD\/BD\/128215\/2016"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UI\/BD\/151255\/2021"],"award-info":[{"award-number":["UI\/BD\/151255\/2021"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["874827"],"award-info":[{"award-number":["874827"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Activated cardiac fibroblasts (CF) play a central role in cardiac fibrosis, a condition associated with most cardiovascular diseases. Conversion of quiescent into activated CF sustains heart integrity upon injury. However, permanence of CF in active state inflicts deleterious heart function effects. Mechanisms underlying this cell state conversion are still not fully disclosed, contributing to a limited target space and lack of effective anti-fibrotic therapies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>To prioritize targets for drug development, we studied CF remodeling upon activation at transcriptomic and proteomic levels, using three different cell sources: primary adult CF (aHCF), primary fetal CF (fHCF), and induced pluripotent stem cells derived CF (hiPSC-CF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All cell sources showed a convergent response upon activation, with clear morphological and molecular remodeling associated with cell-cell and cell-matrix interactions. Quantitative proteomic analysis identified known cardiac fibrosis markers, such as FN1, CCN2, and Serpine1, but also revealed targets not previously associated with this condition, including MRC2, IGFBP7, and NT5DC2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Exploring such targets to modulate CF phenotype represents a valuable opportunity for development of anti-fibrotic therapies. Also, we demonstrate that hiPSC-CF is a suitable cell source for preclinical research, displaying significantly lower basal activation level relative to primary cells, while being able to elicit a convergent response upon stimuli.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2022.1015473","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T06:03:18Z","timestamp":1669874598000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Transcriptome and proteome profiling of activated cardiac fibroblasts supports target prioritization in cardiac fibrosis"],"prefix":"10.3389","volume":"9","author":[{"given":"Maria Raquel","family":"Moita","sequence":"first","affiliation":[]},{"given":"Marta M.","family":"Silva","sequence":"additional","affiliation":[]},{"given":"Cl\u00e1udia","family":"Diniz","sequence":"additional","affiliation":[]},{"given":"Margarida","family":"Serra","sequence":"additional","affiliation":[]},{"given":"Ren\u00e9 M.","family":"Hoet","sequence":"additional","affiliation":[]},{"given":"Ana","family":"Barbas","sequence":"additional","affiliation":[]},{"given":"Daniel","family":"Sim\u00e3o","sequence":"additional","affiliation":[]}],"member":"1965","published-online":{"date-parts":[[2022,12,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1093\/cvr\/cvaa324","article-title":"Cardiac fibrosis.","volume":"117","author":"Frangogiannis","year":"2021","journal-title":"Cardiovasc Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.jacc.2020.10.046","article-title":"Myocardial fibrosis as a predictor of sudden death in patients with coronary artery disease.","volume":"77","author":"Zegard","year":"2021","journal-title":"J Am Coll Cardiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1161\/CIRCRESAHA.115.306565","article-title":"Cardiac fibrosis: the fibroblast awakens.","volume":"118","author":"Travers","year":"2016","journal-title":"Circ Res."},{"key":"B4","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1038\/s41586-020-2938-9","article-title":"Fibrosis: from mechanisms to medicines.","volume":"587","author":"Henderson","year":"2020","journal-title":"Nature."},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00318","article-title":"Novel anti-fibrotic therapies.","volume":"8","author":"McVicker","year":"2017","journal-title":"Front Pharmacol."},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2020.100056","article-title":"Molecular profiling reveals a common metabolic signature of tissue fibrosis.","volume":"1","author":"Zhang","year":"2020","journal-title":"Cell Rep Med."},{"key":"B7","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.jacbts.2019.02.006","article-title":"Fibroblasts in the infarcted, remodeling, and failing heart.","volume":"4","author":"Humeres","year":"2019","journal-title":"JACC Basic to Transl Sci."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.227900","article-title":"The myofibroblast at a glance.","volume":"133","author":"Pakshir","year":"2020","journal-title":"J Cell Sci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1161\/CIRCRESAHA.120.316958","article-title":"Myofibroblasts and fibrosis: mitochondrial and metabolic control of cellular differentiation.","volume":"127","author":"Gibb","year":"2020","journal-title":"Circ Res."},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2020.109888","article-title":"Controlling cardiac fibrosis through fibroblast state space modulation.","volume":"79","author":"Reichardt","year":"2021","journal-title":"Cell Signal."},{"key":"B11","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1038\/nrcardio.2017.57","article-title":"Redefining the identity of cardiac fibroblasts.","volume":"14","author":"Tallquist","year":"2017","journal-title":"Nat Rev Cardiol."},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12260","article-title":"Genetic lineage tracing defines myofibroblast origin and function in the injured heart.","volume":"7","author":"Kanisicak","year":"2016","journal-title":"Nat Commun."},{"key":"B13","doi-asserted-by":"publisher","first-page":"2921","DOI":"10.1172\/JCI74783","article-title":"Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis.","volume":"124","author":"Moore-Morris","year":"2014","journal-title":"J Clin Invest."},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-49285-9","article-title":"An improved method of maintaining primary murine cardiac fibroblasts in two-dimensional cell culture.","volume":"9","author":"Landry","year":"2019","journal-title":"Sci Rep."},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.697270","article-title":"In vitro assays and imaging methods for drug discovery for cardiac fibrosis.","volume":"12","author":"Palano","year":"2021","journal-title":"Front Physiol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"p. 109","DOI":"10.1007\/7651_2020_300","article-title":"Generation of quiescent cardiac fibroblasts derived from human induced pluripotent stem cells.","author":"Zhang","year":"2020","journal-title":"Induced Pluripotent Stem (iPS) Cells. Methods in Molecular Biology."},{"key":"B17","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1093\/cvr\/cvt338","article-title":"Reversible and irreversible differentiation of cardiac fibroblasts.","volume":"101","author":"Driesen","year":"2014","journal-title":"Cardiovasc Res."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10741-018-9720-1","article-title":"Biomarkers for the identification of cardiac fibroblast and myofibroblast cells.","volume":"24","author":"Tarbit","year":"2019","journal-title":"Heart Fail Rev."},{"key":"B19","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.stem.2016.01.022","article-title":"CRISPR interference efficiently induces specific and reversible gene silencing in human iPSCs.","volume":"18","author":"Mandegar","year":"2016","journal-title":"Cell Stem Cell."},{"key":"B20","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1161\/CIRCRESAHA.119.315491","article-title":"Generation of quiescent cardiac fibroblasts from human induced pluripotent stem cells for in vitro modeling of cardiac fibrosis.","volume":"125","author":"Zhang","year":"2019","journal-title":"Circ Res."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1890","DOI":"10.1038\/nprot.2017.080","article-title":"Directed differentiation and long-term maintenance of epicardial cells derived from human pluripotent stem cells under fully defined conditions.","volume":"12","author":"Bao","year":"2017","journal-title":"Nat Protoc."},{"key":"B22","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis.","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat Methods."},{"key":"B23","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method.","volume":"25","author":"Livak","year":"2001","journal-title":"Methods."},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2.","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.18129\/B9.bioc.AnnotationDbi","author":"Pag\u00e8s","year":"2021","journal-title":"AnnotationDbi: Manipulation of SQLite-based annotations in Bioconductor. R Package Version 1.60.0."},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-76603-3","article-title":"VolcaNoseR is a web app for creating, exploring, labeling and sharing volcano plots.","volume":"10","author":"Goedhart","year":"2020","journal-title":"Sci Rep."},{"key":"B27","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources.","volume":"4","author":"Huang","year":"2009","journal-title":"Nat Protoc."},{"key":"B28","doi-asserted-by":"publisher","first-page":"2847","DOI":"10.1093\/bioinformatics\/btw313","article-title":"Complex heatmaps reveal patterns and correlations in multidimensional genomic data.","volume":"32","author":"Gu","year":"2016","journal-title":"Bioinformatics."},{"key":"B29","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1165\/rcmb.2018-0313OC","article-title":"Defining the activated fibroblast population in lung fibrosis using single-cell sequencing.","volume":"61","author":"Peyser","year":"2019","journal-title":"Am J Respir Cell Mol Biol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/0003-2697(84)90782-6","article-title":"A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids.","volume":"138","author":"Wessel","year":"1984","journal-title":"Anal Biochem."},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.O111.016717","article-title":"Targeted data extraction of the MS\/MS spectra generated by data-independent acquisition: a new concept for consistent and accurate proteome analysis.","volume":"11","author":"Gillet","year":"2012","journal-title":"Mol Cell Proteom."},{"key":"B32","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1038\/nprot.2017.147","article-title":"Proteome-wide identification of ubiquitin interactions using UbIA-MS.","volume":"13","author":"Zhang","year":"2018","journal-title":"Nat Protoc."},{"key":"B33","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1038\/nmeth.3901","article-title":"The Perseus computational platform for comprehensive analysis of (prote)omics data.","volume":"13","author":"Tyanova","year":"2016","journal-title":"Nat Methods."},{"key":"B34","doi-asserted-by":"publisher","first-page":"D845","DOI":"10.1093\/nar\/gkz1021","article-title":"The DisGeNET knowledge platform for disease genomics: 2019 update.","volume":"48","author":"Pi\u00f1ero","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"B35","doi-asserted-by":"publisher","first-page":"D1068","DOI":"10.1093\/nar\/gkx1143","article-title":"DGIdb 3.0: a redesign and expansion of the drug-gene interaction database.","volume":"46","author":"Cotto","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1038\/nmeth.2689","article-title":"DGIdb: mining the druggable genome.","volume":"10","author":"Griffith","year":"2013","journal-title":"Nat Methods."},{"key":"B37","doi-asserted-by":"publisher","first-page":"D1302","DOI":"10.1093\/nar\/gkaa1027","article-title":"Open targets platform: supporting systematic drug-target identification and prioritisation.","volume":"49","author":"Ochoa","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"B38","doi-asserted-by":"publisher","first-page":"3442","DOI":"10.1093\/nar\/28.18.3442","article-title":"String: a web-server to retrieve and display the repeatedly occurring neighbourhood of a gene.","volume":"28","author":"Snel","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"B39","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1093\/nar\/gkg034","article-title":"STRING: a database of predicted functional associations between proteins.","volume":"31","author":"von Mering","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"B40","doi-asserted-by":"publisher","first-page":"D605","DOI":"10.1093\/nar\/gkaa1074","article-title":"The STRING database in 2021: customizable protein-protein networks, and functional characterization of user-uploaded gene\/measurement sets.","volume":"49","author":"Szklarczyk","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"B41","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1093\/nar\/gki005","article-title":"STRING: known and predicted protein-protein associations, integrated and transferred across organisms.","volume":"33","author":"von Mering","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"B42","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1093\/nar\/gkl825","article-title":"STRING 7-Recent developments in the integration and prediction of protein interactions.","volume":"35","author":"von Mering","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"B43","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1093\/nar\/gkn760","article-title":"STRING 8-A global view on proteins and their functional interactions in 630 organisms.","volume":"37","author":"Jensen","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"B44","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1093\/nar\/gkq973","article-title":"The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored.","volume":"39","author":"Szklarczyk","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"B45","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1093\/nar\/gks1094","article-title":"STRING v9.1: protein-protein interaction networks, with increased coverage and integration.","volume":"41","author":"Franceschini","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"B46","doi-asserted-by":"publisher","first-page":"D447","DOI":"10.1093\/nar\/gku1003","article-title":"STRING v10: protein-protein interaction networks, integrated over the tree of life.","volume":"43","author":"Szklarczyk","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"B47","doi-asserted-by":"publisher","first-page":"D362","DOI":"10.1093\/nar\/gkw937","article-title":"The STRING database in 2017: quality-controlled protein-protein association networks, made broadly accessible.","volume":"45","author":"Szklarczyk","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"B48","doi-asserted-by":"publisher","first-page":"D607","DOI":"10.1093\/nar\/gky1131","article-title":"STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets.","volume":"47","author":"Szklarczyk","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-81253-0","article-title":"Discovery of a new class of integrin antibodies for fibrosis.","volume":"11","author":"Zhang","year":"2021","journal-title":"Sci Rep."},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201700446","article-title":"Unveiling human cardiac fibroblast membrane proteome.","volume":"18","author":"Sebasti\u00e3o","year":"2018","journal-title":"Proteomics."},{"key":"B51","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1038\/nrd.2016.245","article-title":"Induced pluripotent stem cell technology: a decade of progress.","volume":"16","author":"Shi","year":"2017","journal-title":"Nat Rev Drug Discov."},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202100523R","article-title":"Developmental lineage of human pluripotent stem cell-derived cardiac fibroblasts affects their functional phenotype.","volume":"35","author":"Floy","year":"2021","journal-title":"FASEB J."},{"key":"B53","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.mam.2018.07.001","article-title":"Cardiac fibrosis: cell biological mechanisms, molecular pathways and therapeutic opportunities.","volume":"65","author":"Frangogiannis","year":"2019","journal-title":"Mol Aspects Med."},{"key":"B54","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1177\/108705719900400206","article-title":"A simple statistical parameter for use in evaluation and validation of high throughput screening assays.","volume":"4","author":"Zhang","year":"1999","journal-title":"J Biomol Screen."},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2021.102420","article-title":"Cardiac fibrosis models using human induced pluripotent stem cell-derived cardiac tissues allow anti-fibrotic drug screening in vitro.","volume":"54","author":"Iseoka","year":"2021","journal-title":"Stem Cell Res."},{"key":"B56","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1016\/j.stem.2020.05.004","article-title":"Human-iPSC-derived cardiac stromal cells enhance maturation in 3D cardiac microtissues and reveal non-cardiomyocyte contributions to heart disease.","volume":"26","author":"Giacomelli","year":"2020","journal-title":"Cell Stem Cell."},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.15045","article-title":"Micropattern platform promotes extracellular matrix remodeling by human PSC-derived cardiac fibroblasts and enhances contractility of co-cultured cardiomyocytes.","volume":"9","author":"Napiwocki","year":"2021","journal-title":"Physiol Rep."},{"key":"B58","doi-asserted-by":"publisher","first-page":"H1670","DOI":"10.1152\/AJPHEART.00941.2020","article-title":"Human iPSC-engineered cardiac tissue platform faithfully models important cardiac physiology.","volume":"320","author":"de Lange","year":"2021","journal-title":"Am J Physiol Hear Circ Physiol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1089\/ten.tea.2018.0362","article-title":"Phenotypic variation between stromal cells differentially impacts engineered cardiac tissue function.","volume":"25","author":"Hookway","year":"2019","journal-title":"Tissue Eng Part A."},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a004903","article-title":"Overview of the matrisome-An inventory of extracellular matrix constituents and functions.","volume":"4","author":"Hynes","year":"2012","journal-title":"Cold Spring Harb Perspect Biol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.tips.2017.03.001","article-title":"Cardiac fibroblast activation post-myocardial infarction: current knowledge gaps.","volume":"38","author":"Ma","year":"2017","journal-title":"Trends Pharmacol Sci."},{"key":"B62","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/S2213-2600(19)30262-0","article-title":"Pamrevlumab, an anti-connective tissue growth factor therapy, for idiopathic pulmonary fibrosis (PRAISE): a phase 2, randomised, double-blind, placebo-controlled trial.","volume":"8","author":"Richeldi","year":"2020","journal-title":"Lancet Respir Med."},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1080\/19420862.2019.1703531","article-title":"Antibodies to watch in 2020.","volume":"12","author":"Kaplon","year":"2020","journal-title":"MAbs."},{"key":"B64","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.jacbts.2018.10.007","article-title":"Connective tissue growth factor inhibition enhances cardiac repair and limits fibrosis after myocardial infarction.","volume":"4","author":"Vainio","year":"2019","journal-title":"JACC Basic Transl Sci."},{"key":"B65","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.yjmcc.2015.08.016","article-title":"Fibroblast activation protein alpha expression identifies activated fibroblasts after myocardial infarction.","volume":"87","author":"Tillmanns","year":"2015","journal-title":"J Mol Cell Cardiol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"2267","DOI":"10.1016\/j.jacc.2019.02.049","article-title":"Myofibroblast phenotype and reversibility of fibrosis in patients with end-stage heart failure.","volume":"73","author":"Nagaraju","year":"2019","journal-title":"J Am Coll Cardiol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1038\/s41586-019-1546-z","article-title":"Targeting cardiac fibrosis with engineered T cells.","volume":"573","author":"Aghajanian","year":"2019","journal-title":"Nature."},{"key":"B68","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1126\/science.abm0594","article-title":"CAR T cells produced in vivo to treat cardiac injury.","volume":"375","author":"Rurik","year":"2022","journal-title":"Science."},{"key":"B69","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1093\/carcin\/23.10.1593","article-title":"Molecular proximity of seprase and the urokinase-type plasminogen activator receptor on malignant melanoma cell membranes: dependence on \u03b21 integrins and the cytoskeleton.","volume":"23","author":"Artym","year":"2002","journal-title":"Carcinogenesis."},{"key":"B70","doi-asserted-by":"publisher","first-page":"24947","DOI":"10.1074\/jbc.274.35.24947","article-title":"A novel protease-docking function of integrin at invadopodia.","volume":"274","author":"Mueller","year":"1999","journal-title":"J Biol Chem."},{"key":"B71","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1038\/s12276-020-0397-x","article-title":"Therapeutics targeting the fibrinolytic system.","volume":"52","author":"Lin","year":"2020","journal-title":"Exp Mol Med."},{"key":"B72","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/j.drudis.2020.11.012","article-title":"Small-molecule modulators of serine protease inhibitor proteins (serpins).","volume":"26","author":"Kellici","year":"2021","journal-title":"Drug Discov Today."},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-020-0094-3","article-title":"uPAR antibody (huATN-658) and Zometa reduce breast cancer growth and skeletal lesions.","volume":"8","author":"Mahmood","year":"2020","journal-title":"Bone Res."},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085349","article-title":"Identification of a new epitope in uPAR as a target for the cancer therapeutic monoclonal antibody ATN-658, a structural homolog of the uPAR binding integrin CD11b (\u03b1M).","volume":"9","author":"Xu","year":"2014","journal-title":"PLoS One."},{"key":"B75","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1002\/path.4661","article-title":"Targeting a novel bone degradation pathway in primary bone cancer by inactivation of the collagen receptor uPARAP\/Endo180.","volume":"238","author":"Engelholm","year":"2016","journal-title":"J Pathol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"44605","DOI":"10.18632\/oncotarget.17883","article-title":"The collagen receptor uPARAP\/Endo180 as a novel target for antibody-drug conjugate mediated treatment of mesenchymal and leukemic cancers.","volume":"8","author":"Nielsen","year":"2017","journal-title":"Oncotarget."},{"key":"B77","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1681\/ASN.2011030310","article-title":"Mannose receptor 2 attenuates renal fibrosis.","volume":"23","author":"L\u00f3pez-Guisa","year":"2012","journal-title":"J Am Soc Nephrol."},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-68223-8","article-title":"Anti-integrin \u03b1v therapy improves cardiac fibrosis after myocardial infarction by blunting cardiac PW1+ stromal cells.","volume":"10","author":"Bouvet","year":"2020","journal-title":"Sci Rep."},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-018-1730-1","article-title":"Integrin \u03b1\u03bd\u03b25 in vitro inhibition limits pro-fibrotic response in cardiac fibroblasts of spontaneously hypertensive rats.","volume":"16","author":"Perrucci","year":"2018","journal-title":"J Transl Med."},{"key":"B80","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/j.ejcb.2008.01.012","article-title":"Integrins and the activation of latent transforming growth factor \u03b21-An intimate relationship.","volume":"87","author":"Wipff","year":"2008","journal-title":"Eur J Cell Biol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"499","DOI":"10.2353\/ajpath.2006.041306","article-title":"Increased expression of integrin \u03b1v\u03b25 induces the myofibroblastic differentiation of dermal fibroblasts.","volume":"168","author":"Asano","year":"2006","journal-title":"Am J Pathol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1083\/jcb.200704042","article-title":"Myofibroblast contraction activates latent TGF-\u03b21 from the extracellular matrix.","volume":"179","author":"Wipff","year":"2007","journal-title":"J Cell Biol."},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2021.112790","article-title":"Suppression of latent transforming growth factor-\u03b2 (TGF-\u03b2)-binding protein 1 (LTBP1) inhibits natural killer\/ T cell lymphoma progression by inactivating the TGF-\u03b2\/Smad and p38MAPK pathways.","volume":"407","author":"Lin","year":"2021","journal-title":"Exp Cell Res."},{"key":"B84","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1083\/jcb.136.5.1151","article-title":"Latent transforming growth factor-\u03b2 binding protein domains involved in activation and transglutaminase-dependent cross-linking of latent transforming growth factor-\u03b2.","volume":"136","author":"Nunes","year":"1997","journal-title":"J Cell Biol."},{"key":"B85","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1083\/jcb.120.4.995","article-title":"Role of the latent TGF-\u03b2 binding protein in the activation of latent TGF- \u03b2 by co-cultures of endothelial and smooth muscle cells.","volume":"120","author":"Flaumenhaft","year":"1993","journal-title":"J Cell Biol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"2627","DOI":"10.1091\/mbc.9.9.2627","article-title":"Interactions between growth factors and integrins: latent forms of transforming growth factor-beta are ligands for the integrin alphavbeta1.","volume":"9","author":"Munger","year":"1998","journal-title":"Mol Biol Cell."},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.124529","article-title":"Fibulin-1c regulates transforming growth factor\u2013\u03b2 activation in pulmonary tissue fibrosis.","volume":"4","author":"Liu","year":"2019","journal-title":"JCI Insight."},{"key":"B88","doi-asserted-by":"publisher","first-page":"18871","DOI":"10.1074\/jbc.M410762200","article-title":"Fibronectin regulates latent transforming growth factor-\u03b2 (TGF\u03b2) by controlling matrix assembly of latent TGF\u03b2-binding protein-1.","volume":"280","author":"Dallas","year":"2005","journal-title":"J Biol Chem."},{"key":"B89","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.matbio.2017.12.009","article-title":"Thrombospondin-1 regulation of latent TGF-\u03b2 activation: a therapeutic target for fibrotic disease.","author":"Murphy-Ullrich","year":"2018","journal-title":"Matrix Biol."},{"key":"B90","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.3892\/ijmm.2020.4507","article-title":"Role of thrombospondin\u20131 and thrombospondin\u20132 in cardiovascular diseases (Review).","volume":"45","author":"Zhang","year":"2020","journal-title":"Int J Mol Med."},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.201293","article-title":"The fibronectin ED-A domain enhances recruitment of latent TGF-\u03b2-binding protein-1 to the fibroblast matrix.","volume":"131","author":"Klingberg","year":"2018","journal-title":"J Cell Sci."},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1038\/srep34347","article-title":"Independent multimerization of latent TGF\u03b2 binding protein-1 stabilized by cross-linking and enhanced by heparan sulfate.","volume":"6","author":"Troilo","year":"2016","journal-title":"Sci Rep."},{"key":"B93","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1002\/jcb.20637","article-title":"LTBP-1 blockade in dioxin receptor-null mouse embryo fibroblasts decreases TGF-\u03b2 activity: role of extracellular proteases plasmin and elastase.","volume":"97","author":"Gomez-Duran","year":"2006","journal-title":"J Cell Biochem."},{"key":"B94","doi-asserted-by":"publisher","first-page":"4195","DOI":"10.1242\/jcs.023820","article-title":"The extracellular matrix at a glance.","volume":"123","author":"Frantz","year":"2010","journal-title":"J Cell Sci."},{"key":"B95","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.freeradbiomed.2015.02.015","article-title":"Structure-function analysis of peroxidasin provides insight into the mechanism of collagen IV crosslinking.","volume":"83","author":"L\u00e1z\u00e1r","year":"2015","journal-title":"Free Radic Biol Med."},{"key":"B96","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1093\/cvr\/cvv214","article-title":"Matrix cross-linking lysyl oxidases are induced in response to myocardial infarction and promote cardiac dysfunction.","volume":"109","author":"Gonz\u00e1lez-Santamar\u00eda","year":"2016","journal-title":"Cardiovasc Res."},{"key":"B97","doi-asserted-by":"publisher","first-page":"28465","DOI":"10.1074\/jbc.M114.634311","article-title":"Procollagen lysyl hydroxylase 2 expression is regulated by an alternative downstream transforming growth factor \u03b2-1 activation mechanism.","volume":"290","author":"Gjaltema","year":"2015","journal-title":"J Biol Chem."},{"key":"B98","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1161\/HYPERTENSIONAHA.112.196113","article-title":"Collagen cross-linking but not collagen amount associates with elevated filling pressures in hypertensive patients with stage C heart failure: potential role of lysyl oxidase.","volume":"60","author":"L\u00f3pez","year":"2012","journal-title":"Hypertension."},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13710","article-title":"Targeting LOXL2 for cardiac interstitial fibrosis and heart failure treatment.","volume":"7","author":"Yang","year":"2016","journal-title":"Nat Commun."},{"key":"B100","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1161\/CIRCULATIONAHA.118.034609","article-title":"Inhibiting fibronectin attenuates fibrosis and improves cardiac function in a model of heart failure.","volume":"138","author":"Valiente-Alandi","year":"2018","journal-title":"Circulation."},{"key":"B101","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1016\/j.jhep.2014.06.010","article-title":"Inhibition of fibronectin deposition improves experimental liver fibrosis.","volume":"62","author":"Altrock","year":"2015","journal-title":"J Hepatol."},{"key":"B102","doi-asserted-by":"publisher","first-page":"F1293","DOI":"10.1152\/ajprenal.00117.2019","article-title":"Inhibition of fibronectin polymerization alleviates kidney injury due to ischemia-reperfusion.","volume":"316","author":"Bowers","year":"2019","journal-title":"Am J Physiol Ren Physiol."},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0182679","article-title":"Regulation of hepatic stellate cell proliferation and activation by glutamine metabolism.","volume":"12","author":"Li","year":"2017","journal-title":"PLoS One."},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2019103334","article-title":"Proline biosynthesis is a vent for TGF\u03b2\u2212induced mitochondrial redox stress.","volume":"39","author":"Schw\u00f6rer","year":"2020","journal-title":"EMBO J."},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1101\/2020.05.30.125237","article-title":"PYCR1-dependent proline synthesis in cancer-associated fibroblasts is required for the deposition of pro-tumorigenic extracellular matrix.","author":"Kay","year":"2020","journal-title":"bioRxiv"},{"key":"B106","doi-asserted-by":"publisher","first-page":"18316","DOI":"10.1074\/jbc.RA120.016106","article-title":"In crystallo screening for proline analog inhibitors of the proline cycle enzyme PYCR1.","volume":"295","author":"Christensen","year":"2020","journal-title":"J Biol Chem."},{"key":"B107","doi-asserted-by":"publisher","first-page":"2626","DOI":"10.1016\/j.bmcl.2019.07.047","article-title":"A fragment-like approach to PYCR1 inhibition.","volume":"29","author":"Milne","year":"2019","journal-title":"Bioorganic Med Chem Lett."},{"key":"B108","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1165\/rcmb.2020-0320OC","article-title":"Kindlin-2 acts as a key mediator of lung fibroblast activation and pulmonary fibrosis progression.","volume":"65","author":"Zhang","year":"2021","journal-title":"Am J Respir Cell Mol Biol."},{"key":"B109","doi-asserted-by":"publisher","first-page":"6331","DOI":"10.1111\/febs.15693","article-title":"Metabolic requirements of pulmonary fibrosis: role of fibroblast metabolism.","volume":"288","author":"Hamanaka","year":"2021","journal-title":"FEBS J."},{"key":"B110","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1136\/thoraxjnl-2019-213571","article-title":"GLUT1-dependent glycolysis regulates exacerbation of fibrosis via AIM2 inflammasome activation.","volume":"75","author":"Cho","year":"2020","journal-title":"Thorax."},{"key":"B111","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1165\/rcmb.2016-0225OC","article-title":"Glucose transporter 1-dependent glycolysis is increased during aging-related lung fibrosis, and phloretin inhibits lung fibrosis.","volume":"56","author":"Cho","year":"2017","journal-title":"Am J Respir Cell Mol Biol."},{"key":"B112","doi-asserted-by":"publisher","first-page":"3733","DOI":"10.1096\/fj.201600428R","article-title":"Profibrotic up-regulation of glucose transporter 1 by TGF-\u03b2 involves activation of MEK and mammalian target of rapamycin complex 2 pathways.","volume":"30","author":"Andrianifahanana","year":"2016","journal-title":"FASEB J."},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00774","article-title":"Phloretin prevents diabetic cardiomyopathy by dissociating Keap1\/Nrf2 complex and inhibiting oxidative stress.","volume":"9","author":"Ying","year":"2018","journal-title":"Front Endocrinol."},{"key":"B114","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1161\/CIRCULATIONAHA.119.045115","article-title":"High-resolution transcriptomic profiling of the heart during chronic stress reveals cellular drivers of cardiac fibrosis and hypertrophy.","volume":"142","author":"McLellan","year":"2020","journal-title":"Circulation."},{"key":"B115","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1165\/rcmb.2013-0310OC","article-title":"A novel genomic signature with translational significance for human idiopathic pulmonary fibrosis.","volume":"52","author":"Bauer","year":"2015","journal-title":"Am J Respir Cell Mol Biol."},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15647-5","article-title":"Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis.","volume":"11","author":"Tsukui","year":"2020","journal-title":"Nat Commun."},{"key":"B117","doi-asserted-by":"publisher","first-page":"2213","DOI":"10.7150\/JCA.16539","article-title":"Multidimensional roles of collagen triple helix repeat containing 1 (CTHRC1) in Malignant cancers.","volume":"7","author":"Jiang","year":"2016","journal-title":"J Cancer."},{"key":"B118","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1161\/01.RES.0000154262.07264.12","article-title":"Collagen triple helix repeat containing 1, a novel secreted protein in injured and diseased arteries, inhibits collagen expression and promotes cell migration.","volume":"96","author":"Pyagay","year":"2005","journal-title":"Circ Res."},{"key":"B119","doi-asserted-by":"publisher","first-page":"3320","DOI":"10.7150\/IJBS.57247","article-title":"Nedd4l-induced \u03b2-catenin ubiquitination suppresses the formation and progression of interstitial pulmonary fibrosis via inhibiting the cthrc1\/hif-1\u03b1 axis.","volume":"17","author":"Chen","year":"2021","journal-title":"Int J Biol Sci."},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13115","article-title":"Cthrc1 lowers pulmonary collagen associated with bleomycin-induced fibrosis and protects lung function.","volume":"5","author":"Binks","year":"2017","journal-title":"Physiol Rep."},{"key":"B121","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.ebiom.2019.01.009","article-title":"Autocrine CTHRC1 activates hepatic stellate cells and promotes liver fibrosis by activating TGF-\u03b2 signaling.","volume":"40","author":"Li","year":"2019","journal-title":"Ebiomedicine."},{"key":"B122","doi-asserted-by":"publisher","first-page":"2867","DOI":"10.1021\/acs.jproteome.1c00098","article-title":"Myocardial infarction induces cardiac fibroblast transformation within injured and noninjured regions of the mouse heart.","volume":"20","author":"Shah","year":"2021","journal-title":"J Proteome Res."},{"key":"B123","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1161\/CIRCULATIONAHA.119.044557","article-title":"Single-Cell RNA sequencing analysis reveals a crucial role for CTHRC1 (Collagen Triple Helix Repeat Containing 1) cardiac fibroblasts after myocardial infarction.","volume":"142","author":"Ruiz-Villalba","year":"2020","journal-title":"Circulation."},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-019-1093-z","article-title":"Pirfenidone attenuates lung fibrotic fibroblast responses to transforming growth factor-\u03b21.","volume":"20","author":"Jin","year":"2019","journal-title":"Respir Res."},{"key":"B125","doi-asserted-by":"publisher","first-page":"H512","DOI":"10.1152\/ajpheart.00137.2015","article-title":"Pirfenidone exhibits cardioprotective effects by regulating myocardial fibrosis and vascular permeability in pressure-overloaded hearts.","volume":"309","author":"Yamagami","year":"2015","journal-title":"Am J Physiol Hear Circ Physiol."},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10101565","article-title":"Characterization of the proprotein convertase-mediated processing of peroxidasin and peroxidasin-like protein.","volume":"10","author":"Kov\u00e1cs","year":"2021","journal-title":"Antioxidants."},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1016\/j.mbplus.2019.04.002","article-title":"Quantitative proteomic profiling of extracellular matrix and site-specific collagen post-translational modifications in an in vitro model of lung fibrosis.","volume":"1","author":"Merl-Pham","year":"2019","journal-title":"Matrix Biol Plus."},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-021-02138-8","article-title":"IGFBP7 and GDF-15, but not P1NP, are associated with cardiac alterations and 10-year outcome in an elderly community-based study.","volume":"21","author":"Meessen","year":"2021","journal-title":"BMC Cardiovasc Disord."},{"key":"B129","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1016\/j.amjcard.2014.08.018","article-title":"Prognostic usefulness of insulin-like growth factor-binding protein 7 in heart failure with reduced ejection fraction: a novel biomarker of myocardial diastolic function?","volume":"114","author":"Gandhi","year":"2014","journal-title":"Am J Cardiol."},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-016-0376-2","article-title":"Serum insulin-like growth factor-1 and its binding protein-7: potential novel biomarkers for heart failure with preserved ejection fraction.","volume":"16","author":"Barroso","year":"2016","journal-title":"BMC Cardiovasc Disord."},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-020-01149-x","article-title":"Investigating cytosolic 5\u2019-nucleotidase II family genes as candidates for neuropsychiatric disorders in Drosophila (114\/150 chr).","volume":"11","author":"Singgih","year":"2021","journal-title":"Transl Psychiatry."},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2020.11931","article-title":"NT5DC2 is a novel prognostic marker in human hepatocellular carcinoma.","volume":"20","author":"Chen","year":"2020","journal-title":"Oncol Lett."},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/2607878","article-title":"Comprehensive analysis of prognostic value and immune infiltration of the NT5DC family in hepatocellular carcinoma.","volume":"2022","author":"Li","year":"2022","journal-title":"J Oncol."},{"key":"B134","doi-asserted-by":"publisher","first-page":"5976","DOI":"10.1111\/jcmm.16409","article-title":"NT5DC2 promotes leiomyosarcoma tumour cell growth via stabilizing unpalmitoylated TEAD4 and generating a positive feedback loop.","volume":"25","author":"Hu","year":"2021","journal-title":"J Cell Mol Med."},{"key":"B135","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1161\/CIRCEP.114.001632","article-title":"Left atrial transcriptional changes associated with atrial fibrillation susceptibility and persistence.","volume":"8","author":"Deshmukh","year":"2015","journal-title":"Circ Arrhythmia Electrophysiol."},{"key":"B136","doi-asserted-by":"publisher","first-page":"1570","DOI":"10.21037\/atm-21-4545","article-title":"A novel prognostic signature for idiopathic pulmonary fibrosis based on five-immune-related genes.","volume":"9","author":"Qiu","year":"2021","journal-title":"Ann Transl Med."},{"key":"B137","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s00424-005-1404-8","article-title":"Functional profiling of human atrial and ventricular gene expression.","volume":"450","author":"Barth","year":"2005","journal-title":"Pfl\u00fcgers Arch Eur J Physiol."},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.719922","article-title":"Regulation of extracellular matrix production in activated fibroblasts: roles of amino acid metabolism in collagen synthesis.","volume":"11","author":"Kay","year":"2021","journal-title":"Front Oncol."},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13184610","article-title":"3D cancer models: depicting cellular crosstalk within the tumour microenvironment.","volume":"13","author":"Franchi-Mendes","year":"2021","journal-title":"Cancers."}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2022.1015473\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T06:03:26Z","timestamp":1669874606000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2022.1015473\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,1]]},"references-count":139,"alternative-id":["10.3389\/fcvm.2022.1015473"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2022.1015473","relation":{},"ISSN":["2297-055X"],"issn-type":[{"value":"2297-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,1]]},"article-number":"1015473"}}