{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T04:22:02Z","timestamp":1769746922872,"version":"3.49.0"},"reference-count":72,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T00:00:00Z","timestamp":1719964800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"abstract":"<jats:p>This study investigated how gene expression is affected by dietary fatty acids (FA) by using pigs as a reliable model for studying human diseases that involve lipid metabolism. This includes changes in FA composition in the liver, blood serum parameters and overall metabolic pathways. RNA-Seq data from 32 pigs were analyzed using Weighted Gene Co-expression Network Analysis (WGCNA). Our aim was to identify changes in blood serum parameters and gene expression between diets containing 3% soybean oil (SOY3.0) and a standard pig production diet containing 1.5% soybean oil (SOY1.5). Significantly, both the SOY1.5 and SOY3.0 groups showed significant modules, with a higher number of co-expressed modules identified in the SOY3.0 group. Correlated modules and specific features were identified, including enriched terms and pathways such as the histone acetyltransferase complex, type I diabetes mellitus pathway, cholesterol metabolism, and metabolic pathways in SOY1.5, and pathways related to neurodegeneration and Alzheimer\u2019s disease in SOY3.0. The variation in co-expression observed for HDL in the groups analyzed suggests different regulatory patterns in response to the higher concentration of soybean oil. Key genes co-expressed with metabolic processes indicative of diseases such as Alzheimer\u2019s was also identified, as well as genes related to lipid transport and energy metabolism, including <jats:italic>CCL5, PNISR, DEGS1.<\/jats:italic> These findings are important for understanding the genetic and metabolic responses to dietary variation and contribute to the development of more precise nutritional strategies.<\/jats:p>","DOI":"10.3389\/fgene.2024.1394971","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T05:18:21Z","timestamp":1719983901000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Key co-expressed genes correlated with blood serum parameters of pigs fed with different fatty acid profile diets"],"prefix":"10.3389","volume":"15","author":[{"given":"Simara Larissa","family":"Fanalli","sequence":"first","affiliation":[]},{"given":"J\u00falia Dezen","family":"Gomes","sequence":"additional","affiliation":[]},{"given":"Francisco Jos\u00e9","family":"de Novais","sequence":"additional","affiliation":[]},{"given":"Izally Carvalho","family":"Gerv\u00e1sio","sequence":"additional","affiliation":[]},{"given":"Heidge","family":"Fukumasu","sequence":"additional","affiliation":[]},{"given":"Gabriel Costa Monteiro","family":"Moreira","sequence":"additional","affiliation":[]},{"given":"Luiz Lehmann","family":"Coutinho","sequence":"additional","affiliation":[]},{"given":"James","family":"Koltes","sequence":"additional","affiliation":[]},{"given":"Andreia J.","family":"Amaral","sequence":"additional","affiliation":[]},{"given":"Aline Silva Mello","family":"Cesar","sequence":"additional","affiliation":[]}],"member":"1965","published-online":{"date-parts":[[2024,7,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1007\/s11250-021-02804-1","article-title":"Dietary soybean oil modulates fatty acid composition of pork","volume":"53","author":"Alencar","year":"2021","journal-title":"Trop. 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