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Genet."],"abstract":"<jats:p>The etiology of most health conditions is complex, arising from a combination of risk factors that include both intrinsic (i.e., genetic characteristics) and extrinsic (e.g., behaviors, the environment, social factors) domains. Until relatively recently, health science research typically conflated the biological construct of genetic ancestry with the social constructs of race and ethnicity. The advent of ancestry informative markers (AIMs) and related statistical methods marked an important advance, enabling the quantification of genetic ancestry independent of the constructs of race and ethnicity. Another type of molecular marker (microRNAs) has shown potential utility for quantifying extrinsic domains of risk, including behavioral, environmental, and social factors, within the context of underlying genetic characteristics. 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