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Immunol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>The marine aquaculture industry has been witnessing a worldwide emergence of tenacibaculosis, a poorly understood bacterial disease caused by <jats:italic>Tenacibaculum maritimum<\/jats:italic> that affects commercially important fish. So far, knowledge on the <jats:italic>T. maritimum<\/jats:italic> virulence mechanisms is scarce and the pathogen-host interaction operating in tenacibaculosis remain to be disclosed. This study aimed at contributing to a better understanding of this disease, by evaluating the early innate immune response triggered in European sea bass (<jats:italic>Dicentrarchus labrax<\/jats:italic>) by a bath-challenge with <jats:italic>T. maritimum<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Groups of sea bass were bath-challenged with <jats:italic>T. maritimum<\/jats:italic> (challenged fish) or mock-challenged. Undisturbed fish were used as controls (time 0). Samples of blood, liver and mucosal organs (skin, gills and posterior-intestine) were collected at 0\u00a0h (control) and at 6, 24, 48 and 72\u00a0h post-challenge (n=12). Mucosal organs were used for analyzing the expression of immune-related genes by RT-qPCR, as well as blood samples for assessing haematological and innate humoral parameters and liver for oxidative stress assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>An increased expression of <jats:italic>il-1\u03b2<\/jats:italic>, <jats:italic>il8<\/jats:italic>, <jats:italic>mmp9<\/jats:italic> and <jats:italic>hamp1<\/jats:italic> was detected in all mucosal organs of infected fish when compared with control and mock-challenged fish, suggesting a pro-inflammatory response against <jats:italic>T. maritimum<\/jats:italic> transversal to all organs. The faster induction of these pro-inflammatory genes was observed in the gills. Regarding the systemic response, challenged fish presented neutrophilia, monocytosis, signs of anemia, and a decrease of bactericidal and lysozyme activities in plasma. Almost no variations were observed regarding hepatic oxidative stress.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion\/Conclusions<\/jats:title><jats:p>The present study suggests that <jats:italic>T. maritimum<\/jats:italic> induces a local innate immune response upon bath infection not only in the skin of European sea bass, but also in the gills and posterior-intestine, likely triggered by the <jats:italic>T. maritimum<\/jats:italic>\u2019s capacity to adhere, colonize and damage these organs that can function as entry ways to bacteria, leading ultimately to the seen host\u2019s systemic response.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fimmu.2023.1254677","type":"journal-article","created":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T07:44:25Z","timestamp":1693813465000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["Early innate immune responses in European sea bass (Dicentrarchus labrax L.) 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