{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T03:04:18Z","timestamp":1776222258453,"version":"3.50.1"},"reference-count":338,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T00:00:00Z","timestamp":1710460800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Mounting evidence progressively appreciates the vital interplay between immunity and metabolism in a wide array of immunometabolic chronic disorders, both autoimmune and non-autoimmune mediated. The immune system regulates the functioning of cellular metabolism within organs like the brain, pancreas and\/or adipose tissue by sensing and adapting to fluctuations in the microenvironment\u2019s nutrients, thereby reshaping metabolic pathways that greatly impact a pro- or anti-inflammatory immunophenotype. While it is agreed that the immune system relies on an adequate nutritional status to function properly, we are only just starting to understand how the supply of single or combined nutrients, all of them termed immunonutrients, can steer immune cells towards a less inflamed, tolerogenic immunophenotype. Polyphenols, a class of secondary metabolites abundant in Mediterranean foods, are pharmacologically active natural products with outstanding immunomodulatory actions. Upon binding to a range of receptors highly expressed in immune cells (e.g. AhR, RAR, RLR), they act in immunometabolic pathways through a mitochondria-centered multi-modal approach. <jats:italic>First<\/jats:italic>, polyphenols activate nutrient sensing via stress-response pathways, essential for immune responses. <jats:italic>Second<\/jats:italic>, they regulate mammalian target of rapamycin (mTOR)\/AMP-activated protein kinase (AMPK) balance in immune cells and are well-tolerated caloric restriction mimetics. <jats:italic>Third<\/jats:italic>, polyphenols interfere with the assembly of NLR family pyrin domain containing 3 (NLRP3) in endoplasmic reticulum-mitochondria contact sites, inhibiting its activation while improving mitochondrial biogenesis and autophagosome-lysosome fusion. <jats:italic>Finally<\/jats:italic>, polyphenols impact chromatin remodeling and coordinates both epigenetic and metabolic reprogramming. This work moves beyond the well-documented antioxidant properties of polyphenols, offering new insights into the multifaceted nature of these compounds. It proposes a mechanistical appraisal on the regulatory pathways through which polyphenols modulate the immune response, thereby alleviating chronic low-grade inflammation. Furthermore, it draws parallels between pharmacological interventions and polyphenol-based immunonutrition in their modes of immunomodulation across a wide spectrum of socioeconomically impactful immunometabolic diseases such as Multiple Sclerosis, Diabetes (type 1 and 2) or even Alzheimer\u2019s disease. Lastly, it discusses the existing challenges that thwart the translation of polyphenols-based immunonutritional interventions into long-term clinical studies. Overcoming these limitations will undoubtedly pave the way for improving precision nutrition protocols and provide personalized guidance on tailored polyphenol-based immunonutrition plans.<\/jats:p>","DOI":"10.3389\/fimmu.2024.1360065","type":"journal-article","created":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T04:42:43Z","timestamp":1710477763000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":71,"title":["Polyphenols: immunonutrients tipping the balance of immunometabolism in chronic diseases"],"prefix":"10.3389","volume":"15","author":[{"given":"Carolina","family":"Ferreira","sequence":"first","affiliation":[]},{"given":"Pedro","family":"Vieira","sequence":"additional","affiliation":[]},{"given":"Helena","family":"S\u00e1","sequence":"additional","affiliation":[]},{"given":"Jo\u00e3o","family":"Malva","sequence":"additional","affiliation":[]},{"given":"Miguel","family":"Castelo-Branco","sequence":"additional","affiliation":[]},{"given":"Fl\u00e1vio","family":"Reis","sequence":"additional","affiliation":[]},{"given":"Sofia","family":"Viana","sequence":"additional","affiliation":[]}],"member":"1965","published-online":{"date-parts":[[2024,3,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9050519","article-title":"NOD1-targeted immunonutrition approaches: on the way from disease to health","volume":"9","author":"Fern\u00e1ndez-Garc\u00eda","year":"2021","journal-title":"Biomedicines"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3305\/nh.2015.31.sup3.8762","article-title":"Immunonutrition: methodology and applications","author":"Zapatera","year":"2015","journal-title":"Nutricion hospitalaria"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1101248","article-title":"Vitamin A deficiency impairs vaccine-elicited gastrointestinal immunity","volume":"187","author":"Kaufman","year":"2011","journal-title":"J Immunol (Baltimore Md: 1950)"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.22092\/ari.2021.356098.1775","article-title":"Nutrients interaction with the immune system","volume":"76","author":"Noor","year":"2021","journal-title":"Arch Razi Institute"},{"key":"B5","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1136\/bmjnph-2020-000085","article-title":"Nutrition, immunity and COVID-19","volume":"3","author":"Calder","year":"2020","journal-title":"BMJ nutrition Prev Health"},{"key":"B6","doi-asserted-by":"publisher","first-page":"699","DOI":"10.3390\/nu13020699","article-title":"Nutritional components in western\u00a0diet versus mediterranean diet at the gut microbiota\u2013immune system interplay","volume":"13","author":"Garc\u00eda-Montero","year":"2021","journal-title":"Implications Health Disease Nutrients"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01055","article-title":"Changes in nutritional status impact immune cell metabolism and function","volume":"9","author":"Alwarawrah","year":"2018","journal-title":"Front Immunol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3390\/nu12103054","article-title":"Involvement of gut microbiota, microbial metabolites and interaction with polyphenol in host immunometabolism","volume":"12","author":"Man","year":"2020","journal-title":"Nutrients"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.942796","article-title":"Immunosenescence, aging and successful aging","volume":"13","author":"Wang","year":"2022","journal-title":"Front Immunol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"411","DOI":"10.3390\/nu15020411","article-title":"Nutraceuticals as potential therapeutic modulators in immunometabolism","volume":"15","author":"Alba","year":"2023","journal-title":"Nutrients"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclnm.2008.07.015","article-title":"Basics in clinical nutrition: Immunonutrition \u2013 Nutrients which influence immunity: Effect and mechanism of action","volume":"4","author":"Grimble","year":"2009","journal-title":"e-SPEN Eur e-Journal Clin Nutr Metab"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.03160","article-title":"Nutritional modulation of immune function: analysis of evidence, mechanisms, and clinical relevance","volume":"9","author":"Wu","year":"2018","journal-title":"Front Immunol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s40779-017-0122-9","article-title":"Interaction between the gut microbiome and mucosal immune system","volume":"4","author":"Shi","year":"2017","journal-title":"Military Med Res"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1039\/C7FO01383C","article-title":"A combination of quercetin and resveratrol reduces obesity in high-fat diet-fed rats by modulation of gut microbiota","volume":"8","author":"Zhao","year":"2017","journal-title":"Food Funct"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.31138\/mjr.34.1.30","article-title":"Fly me to the immune: immunonutrition in rheumatic diseases","volume":"34","author":"Grammatikopoulou","year":"2023","journal-title":"Mediterr J Rheumatol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2008.00038.x","article-title":"Immunonutrition support for athletes","volume":"66","author":"Nieman","year":"2008","journal-title":"Nutr Rev"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.111.027847","article-title":"Influence of red wine polyphenols and ethanol on the gut microbiota ecology and biochemical biomarkers","volume":"95","author":"Queipo-Ortu\u00f1o","year":"2012","journal-title":"Am J Clin Nutr"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1080\/10942912.2016.1220393","article-title":"Natural polyphenols: an overview","volume":"20","author":"Abbas","year":"2017","journal-title":"Int J Food Properties"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3390\/nu10101523","article-title":"Relationship between mediterranean dietary polyphenol intake and obesity","volume":"10","author":"Castro-Barquero","year":"2018","journal-title":"Nutrients"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2012.03.046","article-title":"Development and validation of an HPLC-method for determination of free and bound phenolic acids in cereals after solid-phase extraction","volume":"134","author":"Irakli","year":"2012","journal-title":"Food Chem"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2010.221","article-title":"Identification of the 100 richest dietary sources of polyphenols: an application of the Phenol-Explorer database","author":"P\u00e9rez-Jim\u00e9nez","year":"2010","journal-title":"Eur J Clin Nutr"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2010.222","article-title":"Web-based eHealth applications with reference to food composition data","author":"Korou\u0161i\u0107 Seljak","year":"2010","journal-title":"Eur J Clin Nutr"},{"key":"B23","first-page":"87","article-title":"Review: dietary phenolic compounds, health benefits and bioaccessibility","volume":"66","author":"GutiErrez-Grijalva","year":"2016","journal-title":"Archivos latinoamericanos nutricion"},{"key":"B24","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1017\/jns.2016.41","article-title":"Flavonoids: an overview","volume":"5","author":"Panche","year":"2016","journal-title":"J Nutr sci"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3390\/nu2121231","article-title":"Chemistry and biochemistry of dietary polyphenols","volume":"2","author":"Tsao","year":"2010","journal-title":"Nutrients"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3390\/foods10112595","article-title":"Polyphenols: from theory to practice","volume":"10","author":"Bertelli","year":"2021","journal-title":"Foods (Basel Switzerland)"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1093\/jaocint\/qsz018","article-title":"Phenols, flavors, and the mediterranean diet","volume":"103","author":"Issaoui","year":"2020","journal-title":"J AOAC Int"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.3390\/antiox11061212","article-title":"Dietary polyphenol, gut microbiota, and health benefits","volume":"11","author":"Wang","year":"2022","journal-title":"Antioxidants"},{"key":"B29","doi-asserted-by":"publisher","first-page":"2189","DOI":"10.3390\/foods11152189","article-title":"Polyphenols as plant-based nutraceuticals: health effects, encapsulation, nano-delivery, and application","volume":"11","author":"Zhang","year":"2022","journal-title":"Foods (Basel Switzerland)"},{"key":"B30","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/B978-0-12-811525-1.00009-9","article-title":"9 - Bioactive compounds and beneficial functions of sprouted grains","volume-title":"Sprouted Grains","author":"Gan","year":"2019"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.btre.2019.e00370","article-title":"Phenolic acids: Natural versatile molecules with promising therapeutic applications","volume":"24","author":"Kumar","year":"2019","journal-title":"Biotechnol Rep (Amsterdam Netherlands)"},{"key":"B32","doi-asserted-by":"publisher","first-page":"55","DOI":"10.5935\/2446-4775.20150006","article-title":"Bioavailability of phenolic compounds: a major challenge for drug development","volume":"9","author":"de Souza","year":"2015","journal-title":"Rev Fitos Eletronica"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3390\/ijms11041321","article-title":"Bioavailability of the polyphenols: status and controversies","volume":"11","author":"D\u2019Archivio","year":"2010","journal-title":"Int J Mol Sci"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1995.1473","article-title":"Polyphenolic flavanols as scavengers of aqueous phase radicals and as chain-breaking antioxidants","volume":"322","author":"Salah","year":"1995","journal-title":"Arch Biochem biophysics"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1021\/jf900591q","article-title":"Effect of fat content on the digestibility and bioaccessibility of cocoa polyphenol by an in vitro digestion model","volume":"57","author":"Ortega","year":"2009","journal-title":"J Agric Food Chem"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1007\/s11130-009-0110-7","article-title":"Bioavailability of phenolic antioxidants associated with dietary fiber: plasma antioxidant capacity after acute and long-term intake in humans","volume":"64","author":"P\u00e9rez-Jim\u00e9nez","year":"2009","journal-title":"Plant foods Hum Nutr (Dordrecht Netherlands)"},{"key":"B37","first-page":"45","article-title":"2 - Polyphenols: Absorption, bioavailability, and metabolomics","volume-title":"Polyphenols: Properties, Recovery, and Applications","author":"Chen","year":"2018"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.2478\/v10102-011-0027-5","article-title":"Toxicological aspects of the use of phenolic compounds in disease prevention","volume":"4","author":"Kyselova","year":"2011","journal-title":"Interdiscip toxicol"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2017.08.117","article-title":"Antioxidant properties of catechins: Comparison with other antioxidants","volume":"241","author":"Grzesik","year":"2018","journal-title":"Food Chem"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1039\/C7FO01554B","article-title":"EGCG evokes Nrf2 nuclear translocation and dampens PTP1B expression to ameliorate metabolic misalignment under insulin resistance condition","volume":"9","author":"Mi","year":"2018","journal-title":"Food Funct"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1934578X211027745","DOI":"10.1177\/1934578X211027745","article-title":"Current state of knowledge on the antioxidant effects and mechanisms of action of polyphenolic compounds","volume":"16","author":"Lv","year":"2021","journal-title":"Natural Product Commun"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.806470","article-title":"Dietary polyphenols and their role in oxidative stress-induced human diseases: insights into protective effects, antioxidant potentials and mechanism(s) of action","volume":"13","author":"Rudrapal","year":"2022","journal-title":"Front Pharmacol"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/81.1.215S","article-title":"Polyphenols: antioxidants and beyond","volume":"81","author":"Scalbert","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2017.07.016","article-title":"Design, synthesis and biological evaluation of hesperetin derivatives as potent anti-inflammatory agent","volume":"121","author":"Ding","year":"2017","journal-title":"Fitoterapia"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114508162110","article-title":"Dihydroxylated phenolic acids derived from microbial metabolism reduce lipopolysaccharide-stimulated cytokine secretion by human peripheral blood mononuclear cells","volume":"102","author":"Monagas","year":"2009","journal-title":"Br J Nutr"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1007\/s11274-013-1464-4","article-title":"Antimicrobial effect and membrane-active mechanism of tea polyphenols against Serratia marcescens","volume":"30","author":"Yi","year":"2014","journal-title":"World J Microbiol Biotechnol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1186\/1472-6882-14-499","article-title":"Cranberry proanthocyanidins have anti-biofilm properties against Pseudomonas aeruginosa","volume":"14","author":"Ulrey","year":"2014","journal-title":"BMC complementary Altern Med"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.7.2266-2268.2002","article-title":"Inhibition of penicillinase by epigallocatechin gallate resulting in restoration of antibacterial activity of penicillin against penicillinase-producing Staphylococcus aureus","volume":"46","author":"Zhao","year":"2002","journal-title":"Antimicrobial Agents chemother"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1186\/s40064-016-3029-0","article-title":"Daily ingestion of catechin-rich beverage increases brown adipose tissue density and decreases extramyocellular lipids in healthy young women","volume":"5","author":"Nirengi","year":"2016","journal-title":"SpringerPlus"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21111419","article-title":"Piceatannol exerts anti-obesity effects in C57BL\/6 mice through modulating adipogenic proteins and gut microbiota","volume":"21","author":"Tung","year":"2016","journal-title":"Molecules (Basel Switzerland)"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2013.11.016","article-title":"Resveratrol attenuates hepatic steatosis in high-fat fed mice by decreasing lipogenesis and inflammation","volume":"30","author":"Andrade","year":"2014","journal-title":"Nutr (Burbank Los Angeles County Calif)"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1039\/C8FO00978C","article-title":"Vanillic acid activates thermogenesis in brown and white adipose tissue","volume":"9","author":"Han","year":"2018","journal-title":"Food Funct"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2017.07.017","article-title":"Immunomodulatory potential of hesperetin and chrysin through the cellular and humoral response","volume":"812","author":"Sassi","year":"2017","journal-title":"Eur J Pharmacol"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.202300052","article-title":"Polyphenols cause structure dependent effects on the metabolic profile of human hepatocarcinogenic cells","volume":"67","author":"Gerdemann","year":"2023","journal-title":"Mol Nutr Food Res"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-0301-1","article-title":"Signaling networks in immunometabolism","volume":"30","author":"Saravia","year":"2020","journal-title":"Cell Res"},{"key":"B56","doi-asserted-by":"publisher","first-page":"15077","DOI":"10.3390\/ijms232315077","article-title":"UCP2 as a cancer target through energy metabolism and oxidative stress control","volume":"23","author":"Luby","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.3390\/nu13030823","article-title":"How changes in the nutritional landscape shape gut immunometabolism","volume":"13","author":"Tan","year":"2021","journal-title":"Nutrients"},{"key":"B58","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.immuni.2014.12.030","article-title":"The energy sensor AMPK regulates T cell metabolic adaptation and effector responses in vivo","volume":"42","author":"Blagih","year":"2015","journal-title":"Immunity"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqab079","article-title":"SGLT2 inhibitors as calorie restriction mimetics: insights on longevity pathways and age-related diseases","volume":"162","author":"Hoong","year":"2021","journal-title":"Endocrinology"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.70","article-title":"A guide to immunometabolism for immunologists","volume":"16","author":"O\u2019Neill","year":"2016","journal-title":"Nat Rev Immunol"},{"key":"B61","doi-asserted-by":"publisher","first-page":"5184","DOI":"10.1038\/s41467-022-32849-1","article-title":"Distinct metabolic states guide maturation of inflammatory and tolerogenic dendritic cells","volume":"13","author":"Adamik","year":"2022","journal-title":"Nat Commun"},{"key":"B62","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/nature16187","article-title":"Autophagy maintains stemness by preventing senescence","volume":"529","author":"Garc\u00eda-Prat","year":"2016","journal-title":"Nature"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3796","article-title":"\u03b1-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming","volume":"18","author":"Liu","year":"2017","journal-title":"Nat Immunol"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01605","article-title":"Diverse roles of mitochondria in immune responses: novel insights into immuno-metabolism","volume":"9","author":"Angajala","year":"2018","journal-title":"Front Immunol"},{"key":"B65","doi-asserted-by":"publisher","first-page":"101481","DOI":"10.1016\/j.molmet.2022.101481","article-title":"Organelle transporters and inter-organelle communication as drivers of metabolic regulation and cellular homeostasis","volume":"60","author":"Jain","year":"2022","journal-title":"Mol Metab"},{"key":"B66","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1016\/j.immuni.2018.02.012","article-title":"Mitochondria-endoplasmic reticulum contact sites function as immunometabolic hubs that orchestrate the rapid recall response of memory CD8(+) T cells","volume":"48","author":"Bantug","year":"2018","journal-title":"Immunity"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01834","article-title":"Rewiring mitochondrial metabolism for CD8(+) T cell memory formation and effective cancer immunotherapy","volume":"11","author":"Li","year":"2020","journal-title":"Front Immunol"},{"key":"B68","doi-asserted-by":"publisher","first-page":"102548","DOI":"10.1016\/j.nano.2022.102548","article-title":"Macrophage-targeted shikonin-loaded nanogels for modulation of inflammasome activation","volume":"42","author":"Cardoso","year":"2022","journal-title":"Nanomedicine: nanotechnology biology Med"},{"key":"B69","doi-asserted-by":"publisher","first-page":"4034","DOI":"10.1038\/s41598-019-40619-1","article-title":"The NLRP3 inflammasome modulates glycolysis by increasing PFKFB3 in an IL-1\u03b2-dependent manner in macrophages","volume":"9","author":"Finucane","year":"2019","journal-title":"Sci Rep"},{"key":"B70","doi-asserted-by":"publisher","first-page":"728","DOI":"10.3390\/nu13030728","article-title":"Immunomodulatory effects of dietary polyphenols","volume":"13","author":"Shakoor","year":"2021","journal-title":"Nutrients"},{"key":"B71","doi-asserted-by":"publisher","first-page":"3755","DOI":"10.3390\/molecules26123755","article-title":"Immunomodulatory effects of green tea polyphenols","volume":"26","author":"Wang","year":"2021","journal-title":"Molecules (Basel Switzerland)"},{"key":"B72","doi-asserted-by":"publisher","first-page":"1264074","DOI":"10.1155\/2018\/1264074","article-title":"Regulation of immune function by polyphenols","volume":"2018","author":"Ding","year":"2018","journal-title":"J Immunol Res"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1080\/10408390903584094","article-title":"Effects of flavonoids and other polyphenols on inflammation","volume":"51","author":"Gonz\u00e1lez","year":"2011","journal-title":"Crit Rev Food Sci Nutr"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.12.079","article-title":"Green tea (Camelia sinensis) suppresses B cell production of IgE without inducing apoptosis","volume":"40","author":"Hassanain","year":"2010","journal-title":"Ann Clin Lab sci"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1006\/cimm.1997.1109","article-title":"Polyphenols in chocolate, which have antioxidant activity, modulate immune functions in humans in vitro","volume":"177","author":"Sanbongi","year":"1997","journal-title":"Cell Immunol"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1038\/nri3073","article-title":"Protective and pathogenic functions of macrophage subsets","volume":"11","author":"Murray","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.01.003","article-title":"Quince (Cydonia oblonga Miller) peel polyphenols modulate LPS-induced inflammation in human THP-1-derived macrophages through NF-\u03baB, p38MAPK and Akt inhibition","volume":"418","author":"Essafi-Benkhadir","year":"2012","journal-title":"Biochem Biophys Res Commun"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.3390\/molecules17033574","article-title":"Regulation of inflammatory cytokines in lipopolysaccharide-stimulated RAW 264.7 murine macrophage by 7-O-methyl-naringenin","volume":"17","author":"Soromou","year":"2012","journal-title":"Molecules (Basel Switzerland)"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.3945\/jn.109.105064","article-title":"Resveratrol alters proliferative responses and apoptosis in human activated B lymphocytes in vitro","volume":"139","author":"Zunino","year":"2009","journal-title":"J Nutr"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2013.06.015","article-title":"Identification of daidzein as a ligand of retinoic acid receptor that suppresses expression of matrix metalloproteinase-9 in HaCaT cells","volume":"376","author":"Oh","year":"2013","journal-title":"Mol Cell Endocrinology"},{"key":"B81","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1038\/s41598-017-00233-5","article-title":"Targeting to the non-genomic activity of retinoic acid receptor-gamma by acacetin in hepatocellular carcinoma","volume":"7","author":"Zeng","year":"2017","journal-title":"Sci Rep"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2020.1783119","article-title":"Regulation and repurposing of nutrient sensing and autophagy in innate immunity","volume":"17","author":"Sanchez-Garrido","year":"2021","journal-title":"Autophagy"},{"key":"B83","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s13045-023-01453-1","article-title":"Amino acid metabolism in immune cells: essential regulators of the effector functions, and promising opportunities to enhance cancer immunotherapy","volume":"16","author":"Yang","year":"2023","journal-title":"J Hematol Oncol"},{"key":"B84","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1016\/j.immuni.2014.04.007","article-title":"Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation","volume":"40","author":"Nakaya","year":"2014","journal-title":"Immunity"},{"key":"B85","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/j.smim.2016.09.001","article-title":"Nutrient sensing, signal transduction and immune responses","volume":"28","author":"Walls","year":"2016","journal-title":"Semin Immunol"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.04.004","article-title":"Sirtuin-1 activation controls tumor growth by impeding th17 differentiation via STAT3 deacetylation","volume":"19","author":"Limagne","year":"2017","journal-title":"Cell Rep"},{"key":"B87","doi-asserted-by":"publisher","first-page":"111091","DOI":"10.1016\/j.fct.2019.111091","article-title":"Immune Th17 lymphocytes play a critical role in the multiple beneficial properties of resveratrol","volume":"137","author":"Delmas","year":"2020","journal-title":"Food Chem toxicology: an Int J published Br Ind Biol Res Assoc"},{"key":"B88","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s12964-021-00706-1","article-title":"Interactions among mTORC, AMPK and SIRT: a computational model for cell energy balance and metabolism","volume":"19","author":"Sadria","year":"2021","journal-title":"Cell communication signaling: CCS"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.122.061732","article-title":"Critical reanalysis of the mechanisms underlying the cardiorenal benefits of SGLT2 inhibitors and reaffirmation of the nutrient deprivation signaling\/autophagy hypothesis","volume":"146","author":"Packer","year":"2022","journal-title":"Circulation"},{"key":"B90","doi-asserted-by":"publisher","first-page":"e13948","DOI":"10.1111\/acel.13948","article-title":"Strategies for senolytic drug discovery","volume":"22","author":"Power","year":"2023","journal-title":"Aging Cell"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgg.2021.11.005","article-title":"Mitochondrial sirtuins, metabolism, and aging","volume":"49","author":"Ji","year":"2022","journal-title":"J Genet Genomics = Yi Chuan xue bao"},{"key":"B92","doi-asserted-by":"publisher","first-page":"101596","DOI":"10.1016\/j.arr.2022.101596","article-title":"The role of nutrition in inflammaging","volume":"77","author":"Di Giosia","year":"2022","journal-title":"Ageing Res Rev"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.v8i10","article-title":"Alleviation of senescence and epithelial-mesenchymal transition in aging kidney by short-term caloric restriction and caloric restriction mimetics via modulation of AMPK\/mTOR signaling","volume":"8","author":"Dong","year":"2017","journal-title":"Oncotarget"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2020.02.011","article-title":"Polyphenols as caloric restriction mimetics regulating mitochondrial biogenesis and mitophagy","volume":"31","author":"Davinelli","year":"2020","journal-title":"Trends Endocrinol metabolism: TEM"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.29219\/fnr.v65.6355","article-title":"Fisetin inhibits inflammation and induces autophagy by mediating PI3K\/AKT\/mTOR signaling in LPS-induced RAW264.7 cells","volume":"65","author":"Sun","year":"2021","journal-title":"Food Nutr Res"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.732933","article-title":"NLRP3 inflammasome: checkpoint connecting innate and adaptive immunity in autoimmune diseases","volume":"12","author":"Zhang","year":"2021","journal-title":"Front Immunol"},{"key":"B97","doi-asserted-by":"publisher","first-page":"102010","DOI":"10.1016\/j.redox.2021.102010","article-title":"Quercetin hinders microglial\u00a0activation to alleviate neurotoxicity via the interplay between NLRP3 inflammasome and mitophagy","volume":"44","author":"Han","year":"2021","journal-title":"Redox Biol"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxv018","article-title":"Resveratrol inhibits the acetylated \u03b1-tubulin-mediated assembly of the NLRP3-inflammasome","volume":"27","author":"Misawa","year":"2015","journal-title":"Int Immunol"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1039\/C8FO00387D","article-title":"Cocoa procyanidins modulate transcriptional pathways linked to inflammation and metabolism in human dendritic cells","volume":"9","author":"Midttun","year":"2018","journal-title":"Food Funct"},{"key":"B100","doi-asserted-by":"publisher","first-page":"100049","DOI":"10.1016\/j.dscb.2022.100049","article-title":"The promising role of natural products in Alzheimer\u2019s disease","volume":"7","author":"da Rosa","year":"2022","journal-title":"Brain Disord"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2019.12.008","article-title":"Metabolic regulation of epigenetic remodeling in immune cells","volume":"63","author":"Britt","year":"2020","journal-title":"Curr Opin Biotechnol"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.362343","article-title":"NAD+-dependent sirtuin 1 and 6 proteins coordinate a switch from glucose to fatty acid oxidation during the acute inflammatory response","volume":"287","author":"Liu","year":"2012","journal-title":"J Biol Chem"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24065542","article-title":"Quercetin reprograms immunometabolism of macrophages via the SIRT1\/PGC-1\u03b1 Signaling pathway to ameliorate lipopolysaccharide-induced oxidative damage","volume":"24","author":"Peng","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B104","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/1868-7083-3-4","article-title":"Dietary phytochemicals, HDAC inhibition, and DNA damage\/repair defects in cancer cells","volume":"3","author":"Rajendran","year":"2011","journal-title":"Clin epigenetics"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2011.09.109","article-title":"Epigenetic modulation of mechanisms involved in inflammation: Influence of selected polyphenolic substances on histone acetylation state","volume":"131","author":"Kiss","year":"2012","journal-title":"Food Chem"},{"key":"B106","doi-asserted-by":"publisher","first-page":"639469","DOI":"10.1155\/2012\/639469","article-title":"Fisetin inhibits hyperglycemia-induced proinflammatory cytokine production by epigenetic mechanisms","volume":"2012","author":"Kim","year":"2012","journal-title":"Evidence-Based complementary Altern medicine: eCAM"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1017\/S000711451000005X","article-title":"Effects of epigallocatechin gallate on regulatory T cell number and function in obese v. lean volunteers","volume":"103","author":"Yun","year":"2010","journal-title":"Br J Nutr"},{"key":"B108","doi-asserted-by":"publisher","first-page":"e1700722","DOI":"10.1002\/mnfr.201700722","article-title":"Polyphenolic compounds alter stress-induced patterns of global DNA methylation in brain and blood","volume":"62","author":"Blaze","year":"2018","journal-title":"Mol Nutr Food Res"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2009.03205.x","article-title":"Dendritic cells treated with resveratrol during differentiation from monocytes gain substantial tolerogenic properties upon activation","volume":"129","author":"\u0160vajger","year":"2010","journal-title":"Immunology"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2014.06.006","article-title":"Downregulation of tumor necrosis factor and other proinflammatory biomarkers by polyphenols","volume":"559","author":"Gupta","year":"2014","journal-title":"Arch Biochem biophysics"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903991","article-title":"Immunosuppressive effect of quercetin on dendritic cell activation and function","volume":"184","author":"Huang","year":"2010","journal-title":"J Immunol (Baltimore Md: 1950)"},{"key":"B112","doi-asserted-by":"publisher","first-page":"1700031","DOI":"10.1002\/mnfr.v61.9","article-title":"Quercetin protects against atherosclerosis by inhibiting dendritic cell activation","volume":"61","author":"Lin","year":"2017","journal-title":"Mol Nutr Food Res"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.08.026","article-title":"Epigallocatechin gallate affects human dendritic cell differentiation and maturation","volume":"121","author":"Yoneyama","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.12.8116","article-title":"Curcumin inhibits immunostimulatory function of dendritic cells: MAPKs and translocation of NF-kappa B as potential targets","volume":"174","author":"Kim","year":"2005","journal-title":"J Immunol (Baltimore Md: 1950)"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1124\/mol.106.024547","article-title":"Apigenin inhibits immunostimulatory function of dendritic cells: Implication of immunotherapeutic adjuvant","volume":"70","author":"Yoon","year":"2006","journal-title":"Mol Pharmacol"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2011.09.002","article-title":"Suppression of dendritic cells\u2019 maturation and functions by daidzein, a phytoestrogen","volume":"257","author":"Yum","year":"2011","journal-title":"Toxicol Appl Pharmacol"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.12200FP","article-title":"Baicalin from Scutellaria baicalensis impairs Th1 polarization through inhibition of dendritic cell maturation","volume":"121","author":"Kim","year":"2013","journal-title":"J Pharmacol Sci"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1021\/jf1017093","article-title":"Fisetin inhibits lipopolysaccharide-induced macrophage activation and dendritic cell maturation","volume":"58","author":"Liu","year":"2010","journal-title":"J Agric Food Chem"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.20852","article-title":"Silibinin polarizes Th1\/Th2 immune responses through the inhibition of immunostimulatory function of dendritic cells","volume":"210","author":"Lee","year":"2007","journal-title":"J Cell Physiol"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2003.11.108","article-title":"Epigallocatechin-3-gallate, constituent of green tea, suppresses the LPS-induced phenotypic and functional maturation of murine dendritic cells through inhibition of mitogen-activated protein kinases and NF-kappaB","volume":"313","author":"Ahn","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00345","article-title":"Plant-derived polyphenols modulate human dendritic cell metabolism and immune function via AMPK-dependent induction of heme oxygenase-1","volume":"10","author":"Campbell","year":"2019","journal-title":"Front Immunol"},{"key":"B122","doi-asserted-by":"publisher","first-page":"6293740","DOI":"10.1155\/2017\/6293740","article-title":"Effect of cocoa polyphenolic extract on macrophage polarization from proinflammatory M1 to anti-inflammatory M2 state","volume":"2017","author":"Dugo","year":"2017","journal-title":"Oxid Med Cell longevity"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2016.1158295","article-title":"Resveratrol prevents tumor growth and metastasis by inhibiting lymphangiogenesis and M2 macrophage activation and differentiation in tumor-associated macrophages","volume":"68","author":"Kimura","year":"2016","journal-title":"Nutr cancer"},{"key":"B124","doi-asserted-by":"publisher","first-page":"45673","DOI":"10.1155\/2007\/45673","article-title":"Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages","volume":"2007","author":"H\u00e4m\u00e4l\u00e4inen","year":"2007","journal-title":"Med Inflamm"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0107072","article-title":"Flavonoid apigenin inhibits lipopolysaccharide-induced inflammatory response through multiple mechanisms in macrophages","volume":"9","author":"Zhang","year":"2014","journal-title":"PloS One"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050419","article-title":"Protective effects of grape seed proanthocyanidins against oxidative stress induced by lipopolysaccharides of periodontopathogens","volume":"77","author":"Houde","year":"2006","journal-title":"J periodontology"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.3390\/foods12020254","article-title":"Anti-inflammatory effects of polyphenols from plum (Prunus salicina lindl) on RAW264.7 macrophages induced by monosodium urate and potential mechanisms","volume":"12","author":"Li","year":"2023","journal-title":"Foods (Basel Switzerland)"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1024\/0300-9831\/a000157","article-title":"Orange juice and hesperidin promote differential innate immune response in macrophages ex vivo","volume":"83","author":"Zanotti Simoes Dourado","year":"2013","journal-title":"Int J vitamin Nutr Res Internationale Z fur Vitamin- und Ernahrungsforschung J Int vitaminologie Nutr"},{"key":"B129","doi-asserted-by":"publisher","first-page":"14906","DOI":"10.1038\/s41598-019-51113-z","article-title":"Flavonoid-mediated immunomodulation of human macrophages involves key metabolites and metabolic pathways","volume":"9","author":"Mendes","year":"2019","journal-title":"Sci Rep"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1995.1076","article-title":"Curcumin, an anti-tumour promoter and anti-inflammatory agent, inhibits induction of nitric oxide synthase in activated macrophages","volume":"206","author":"Brouet","year":"1995","journal-title":"Biochem Biophys Res Commun"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1023\/a:1007005605869","article-title":"Dietary n-3 fatty acids, curcumin and capsaicin lower the release of lysosomal enzymes and eicosanoids in rat peritoneal macrophages","volume":"203","author":"Joe","year":"2000","journal-title":"Mol Cell Biochem"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0702357","article-title":"Suppression of nitric oxide synthase and the down-regulation of the activation of NFkappaB in macrophages by resveratrol","volume":"126","author":"Tsai","year":"1999","journal-title":"Br J Pharmacol"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(00)00471-8","article-title":"Synergy between ethanol and grape polyphenols, quercetin, and resveratrol, in the inhibition of the inducible nitric oxide synthase pathway","volume":"60","author":"Chan","year":"2000","journal-title":"Biochem Pharmacol"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1124\/mol.52.3.465","article-title":"(-)-Epigallocatechin-3-gallate blocks the induction of nitric oxide synthase by down-regulating lipopolysaccharide-induced activity of transcription factor nuclear factor-kappaB","volume":"52","author":"Lin","year":"1997","journal-title":"Mol Pharmacol"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1007\/BF02980029","article-title":"Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 activity by 1,2,3,4,6-penta-O-galloyl-beta-D-glucose in murine macrophage cells","volume":"26","author":"Lee","year":"2003","journal-title":"Arch pharmacal Res"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1993.265.3.H1014","article-title":"Tyrosine kinase inhibitors suppress endotoxin- and IL-1 beta-induced NO synthesis in aortic smooth muscle cells","volume":"265","author":"Marczin","year":"1993","journal-title":"Am J Physiology-Heart Circulatory Physiol"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.12.135","article-title":"Curcumin enhances non-inflammatory phagocytic activity of RAW264.7 cells","volume":"379","author":"Bisht","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"B138","article-title":"Epigallocatechin gallate (EGCG), influences a murine WEHI-3 leukemia model in vivo through enhancing phagocytosis of macrophages and populations of T- and B-cells","volume":"27","author":"Huang","year":"2013","journal-title":"In Vivo (Athens Greece)"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-018-2130-3","article-title":"TriCurin, a synergistic formulation of curcumin, resveratrol, and epicatechin gallate, repolarizes tumor-associated macrophages and triggers an immune response to cause suppression of HPV+ tumors","volume":"67","author":"Mukherjee","year":"2018","journal-title":"Cancer immunology immunotherapy: CII"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.3390\/nu7064107","article-title":"Blueberries improve endothelial function, but not blood pressure, in adults with metabolic syndrome: a randomized, double-blind, placebo-controlled clinical trial","volume":"7","author":"Stull","year":"2015","journal-title":"Nutrients"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2012.03.024","article-title":"EGCG protects endothelial cells against PCB 126-induced inflammation through inhibition of AhR and induction of Nrf2-regulated genes","volume":"261","author":"Han","year":"2012","journal-title":"Toxicol Appl Pharmacol"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2015.08.041","article-title":"Redox-active biflavonoids from Garcinia brasiliensis as inhibitors of neutrophil oxidative burst and human erythrocyte membrane damage","volume":"174","author":"Saroni Arwa","year":"2015","journal-title":"J ethnopharmacology"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2006.08.001","article-title":"Viscolin, a new chalcone from Viscum coloratum, inhibits human neutrophil superoxide anion and elastase release via a cAMP-dependent pathway","volume":"41","author":"Hwang","year":"2006","journal-title":"Free Radical Biol Med"},{"key":"B144","doi-asserted-by":"publisher","first-page":"65","DOI":"10.2478\/v10102-012-0011-8","article-title":"Polyphenol derivatives - potential regulators of neutrophil activity","volume":"5","author":"Dr\u00e1bikov\u00e1","year":"2012","journal-title":"Interdiscip toxicol"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-018-0511-z","article-title":"Grape polyphenols corrects ageing-related detriments in neutrophil functionality via modulation of specific molecular targets","volume":"26","author":"Petersen","year":"2018","journal-title":"Inflammopharmacology"},{"key":"B146","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1038\/s41419-023-06190-4","article-title":"Polyphenol-rich diet mediates interplay between macrophage-neutrophil and gut microbiota to alleviate intestinal inflammation","volume":"14","author":"Han","year":"2023","journal-title":"Cell Death disease"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.622306","article-title":"The role of natural killer cells in autoimmune diseases","volume":"12","author":"Kucuksezer","year":"2021","journal-title":"Front Immunol"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.6b01115","article-title":"Green tea catechin metabolites exert immunoregulatory effects on CD4(+) T cell and natural killer cell activities","volume":"64","author":"Kim","year":"2016","journal-title":"J Agric Food Chem"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2012.655424","article-title":"Protective effect of dietary flavonoid quercetin against lipemic-oxidative hepatic injury in hypercholesterolemic rats","volume":"50","author":"Mariee","year":"2012","journal-title":"Pharm Biol"},{"key":"B150","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/S0024-3205(01)01367-4","article-title":"Effects of resveratrol on human immune cell function","volume":"70","author":"Falchetti","year":"2001","journal-title":"Life Sci"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0907647","article-title":"Resveratrol ameliorates Serratia marcescens-induced acute pneumonia in rats","volume":"83","author":"Lu","year":"2008","journal-title":"J leukocyte Biol"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22043","article-title":"Resveratrol enhances perforin expression and NK cell cytotoxicity through NKG2D-dependent pathways","volume":"223","author":"Lu","year":"2010","journal-title":"J Cell Physiol"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0712310105","article-title":"JNK MAP kinase activation is required for MTOC and granule polarization in NKG2D-mediated NK cell cytotoxicity","volume":"105","author":"Li","year":"2008","journal-title":"Proc Natl Acad Sci United States America"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1177\/2010105820979006","article-title":"Immunomodulatory effects of flavonoids: An experimental study on natural-killer-cell-mediated cytotoxicity against lung cancer and cytotoxic granule secretion profile","volume":"30","author":"Oo","year":"2021","journal-title":"Proc Singapore Healthcare"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-0857","article-title":"Low concentrations of the soy phytoestrogen genistein induce proteinase inhibitor 9 and block killing of breast cancer cells by immune cells","volume":"149","author":"Jiang","year":"2008","journal-title":"Endocrinology"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgm223","article-title":"Decreased 7,12-dimethylbenz[a]anthracene-induced carcinogenesis coincides with the induction of antitumor immunities in adult female B6C3F1 mice pretreated with genistein","volume":"28","author":"Guo","year":"2007","journal-title":"Carcinogenesis"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1139\/h11-120","article-title":"Effect of blueberry ingestion on natural killer cell counts, oxidative stress, and inflammation prior to and after 2.5 h of running","volume":"36","author":"McAnulty","year":"2011","journal-title":"Appl physiology nutrition Metab = Physiologie appliquee Nutr metabolisme"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2014.07.002","article-title":"Six weeks daily ingestion of whole blueberry powder increases natural killer cell counts and reduces arterial stiffness in sedentary males and females","volume":"34","author":"McAnulty","year":"2014","journal-title":"Nutr Res (New York NY)"},{"key":"B159","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.imlet.2011.04.009","article-title":"Induction of regulatory T cells by green tea polyphenol EGCG","volume":"139","author":"Wong","year":"2011","journal-title":"Immunol Lett"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017164","article-title":"Identification of Baicalin as an immunoregulatory compound by controlling T(H)17 cell differentiation","volume":"6","author":"Yang","year":"2011","journal-title":"PloS One"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b15-00331","article-title":"Epigallocatechin-3-gallate (EGCG) suppresses the trafficking of lymphocytes to epidermal melanocytes via inhibition of JAK2: its implication for vitiligo treatment","volume":"38","author":"Ning","year":"2015","journal-title":"Biol Pharm bulletin"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-2638","article-title":"Epigallocatechin-3-gallate enhances CD8+ T cell-mediated antitumor immunity induced by DNA vaccination","volume":"67","author":"Kang","year":"2007","journal-title":"Cancer Res"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1562\/2005-04-11-RA-487","article-title":"Epigallocatechin-3-gallate inhibits photocarcinogenesis through inhibition of angiogenic factors and activation of CD8+ T cells in tumors","volume":"81","author":"Mantena","year":"2005","journal-title":"Photochem photobiology"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2007.03430.x","article-title":"Spleen lymphocyte function modulated by a cocoa-enriched diet","volume":"149","author":"Ramiro-Puig","year":"2007","journal-title":"Clin Exp Immunol"},{"key":"B165","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.ejphar.2015.01.017","article-title":"Auraptene has the inhibitory property on murine T lymphocyte activation","volume":"750","author":"Niu","year":"2015","journal-title":"Eur J Pharmacol"},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.1006\/taap.2002.9418","article-title":"Genistein modulates splenic natural killer cell activity, antibody-forming cell response, and phenotypic marker expression in F(0) and F(1) generations of Sprague-Dawley rats","volume":"181","author":"Guo","year":"2002","journal-title":"Toxicol Appl Pharmacol"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.2000.5826","article-title":"Inhibition of intestinal tumors by curcumin is associated with changes in the intestinal immune cell profile","volume":"89","author":"Churchill","year":"2000","journal-title":"J Surg Res"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2007.00089.x","article-title":"Curcumin modulation of IFN-beta and IL-12 signalling and cytokine induction in human T cells","volume":"11","author":"Fahey","year":"2007","journal-title":"J Cell Mol Med"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2006.03257.x","article-title":"Resveratrol and curcumin suppress immune response through CD28\/CTLA-4 and CD80 co-stimulatory pathway","volume":"147","author":"Sharma","year":"2007","journal-title":"Clin Exp Immunol"},{"key":"B170","first-page":"47","article-title":"The effect of curcumin on human B-cell immortalization by Epstein-Barr virus","volume":"64","author":"Ranjan","year":"1998","journal-title":"Am surgeon"},{"key":"B171","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.1080\/1042819021000015952","article-title":"Comparative antiproliferative and apoptotic effects of resveratrol, epsilon-viniferin and vine-shots derived polyphenols (vineatrols) on chronic B lymphocytic leukemia cells and normal human lymphocytes","volume":"43","author":"Billard","year":"2002","journal-title":"Leukemia lymphoma"},{"key":"B172","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/imr.12858","article-title":"Immunometabolism: From basic mechanisms to translation","volume":"295","author":"Makowski","year":"2020","journal-title":"Immunol Rev"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvad035","article-title":"Caloric restriction for the immunometabolic control of human health","volume":"119","author":"Procaccini","year":"2023","journal-title":"Cardiovasc Res"},{"key":"B174","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/nri2922","article-title":"Immunometabolism: an emerging frontier","volume":"11","author":"Mathis","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"B175","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.3390\/nu11081933","article-title":"Diet and immune function","volume":"11","author":"Childs","year":"2019","journal-title":"Nutrients"},{"key":"B176","volume-title":"Autoimmunity. from bench to bedside","author":"Anaya","year":"2013"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.286.6369.926","article-title":"Low serum C4 concentrations: an inherited predisposition to insulin dependent diabetes","volume":"286","author":"Vergani","year":"1983","journal-title":"Br Med J (Clinical Res ed)"},{"key":"B178","doi-asserted-by":"publisher","first-page":"4106518","DOI":"10.1155\/2020\/4106518","article-title":"Two to tango: dialogue between adaptive and innate immunity in type 1 diabetes","volume":"2020","author":"Sun","year":"2020","journal-title":"J Diabetes Res"},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.2337\/db11-1635","article-title":"Adoptive transfer of immunomodulatory M2 macrophages prevents type 1 diabetes in NOD mice","volume":"61","author":"Parsa","year":"2012","journal-title":"Diabetes"},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402065101","article-title":"Natural killer cells distinguish innocuous and destructive forms of pancreatic islet autoimmunity","volume":"101","author":"Poirot","year":"2004","journal-title":"Proc Natl Acad Sci United States America"},{"key":"B181","doi-asserted-by":"publisher","first-page":"2","DOI":"10.4161\/auto.7.1.13044","article-title":"The emerging role of autophagy in the pathophysiology of diabetes mellitus","volume":"7","author":"Gonzalez","year":"2011","journal-title":"Autophagy"},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1130662","article-title":"The influence of high glucose conditions on macrophages and its effect on the autophagy pathway","volume":"14","author":"Sousa","year":"2023","journal-title":"Front Immunol"},{"key":"B183","doi-asserted-by":"publisher","first-page":"486403","DOI":"10.1155\/2014\/486403","article-title":"Stress hyperglycemia, insulin treatment, and innate immune cells","volume":"2014","author":"Xiu","year":"2014","journal-title":"Int J endocrinology"},{"key":"B184","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.cytogfr.2019.11.006","article-title":"Insulin as an immunomodulatory hormone","volume":"52","author":"van Niekerk","year":"2020","journal-title":"Cytokine Growth factor Rev"},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27185","article-title":"Insulin promotes macrophage phenotype transition through PI3K\/Akt and PPAR-\u03b3 signaling during diabetic wound healing","volume":"234","author":"Yu","year":"2019","journal-title":"J Cell Physiol"},{"key":"B186","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.914136","article-title":"New developments in T cell immunometabolism and therapeutic implications for type 1 diabetes","volume":"13","author":"Zhang","year":"2022","journal-title":"Front endocrinology"},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.669456","article-title":"Glycolysis inhibition induces functional and metabolic exhaustion of CD4(+) T cells in type 1 diabetes","volume":"12","author":"Martins","year":"2021","journal-title":"Front Immunol"},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.2337\/db11-0090","article-title":"Expansion of Th17 cells and functional defects in T regulatory cells are key features of the pancreatic lymph nodes in patients with type 1 diabetes","volume":"60","author":"Ferraro","year":"2011","journal-title":"Diabetes"},{"key":"B189","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20071878","article-title":"Innocuous IFNgamma induced by adjuvant-free antigen restores normoglycemia in NOD mice through inhibition of IL-17 production","volume":"205","author":"Jain","year":"2008","journal-title":"J Exp Med"},{"key":"B190","doi-asserted-by":"publisher","first-page":"10835","DOI":"10.1038\/s41598-017-11056-9","article-title":"T cells display mitochondria hyperpolarization in human type 1 diabetes","volume":"7","author":"Chen","year":"2017","journal-title":"Sci Rep"},{"key":"B191","doi-asserted-by":"publisher","DOI":"10.1039\/C7FO00127D","article-title":"Ursolic acid induces mitochondrial biogenesis through the activation of AMPK and PGC-1 in C2C12 myotubes: a possible mechanism underlying its beneficial effect on exercise endurance","volume":"8","author":"Chen","year":"2017","journal-title":"Food Funct"},{"key":"B192","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.11.013","article-title":"Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha","volume":"127","author":"Lagouge","year":"2006","journal-title":"Cell"},{"key":"B193","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.90925.2008","article-title":"Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance","volume":"296","author":"Davis","year":"2009","journal-title":"Am J Physiol Regulatory Integr Comp Physiol"},{"key":"B194","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3181b18fa3","article-title":"Quercetin\u2019s influence on exercise performance and muscle mitochondrial biogenesis","volume":"42","author":"Nieman","year":"2010","journal-title":"Med Sci sports exercise"},{"key":"B195","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2009.09.006","article-title":"Hydroxytyrosol protects against oxidative damage by simultaneous activation of mitochondrial biogenesis and phase II detoxifying enzyme systems in retinal pigment epithelial cells","volume":"21","author":"Zhu","year":"2010","journal-title":"J Nutr Biochem"},{"key":"B196","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2017.06.021","article-title":"Pomegranate peel extract ameliorates autoimmunity in animal models of multiple sclerosis and type 1 diabetes","volume":"35","author":"Stojanovi\u0107","year":"2017","journal-title":"J Funct Foods"},{"key":"B197","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1038\/mi.2011.50","article-title":"Oral ingestion of Capsaicin, the pungent component of chili pepper, enhances a discreet population of macrophages and confers protection from autoimmune diabetes","volume":"5","author":"Nevius","year":"2012","journal-title":"Mucosal Immunol"},{"key":"B198","doi-asserted-by":"publisher","first-page":"113952","DOI":"10.1016\/j.bcp.2020.113952","article-title":"Procyanidin B2 gallate regulates TNF-\u03b1 production from T cells through inhibiting glycolytic activity via mTOR-HIF-1 pathway","volume":"177","author":"Endo","year":"2020","journal-title":"Biochem Pharmacol"},{"key":"B199","doi-asserted-by":"publisher","DOI":"10.1016\/j.aller.2011.07.002","article-title":"Immunomodulatory effects of black seeds and garlic on alloxan-induced Diabetes in albino rat","volume":"40","author":"Abel-Salam","year":"2012","journal-title":"Allergologia immunopathologia"},{"key":"B200","doi-asserted-by":"publisher","DOI":"10.3109\/08923970903490486","article-title":"Immunomodulatory, beta-cell, and neuroprotective actions of fenugreek oil from alloxan-induced diabetes","volume":"32","author":"Hamden","year":"2010","journal-title":"Immunopharmacol immunotoxicology"},{"key":"B201","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S353038","article-title":"Immunology of inflammatory bowel disease: molecular mechanisms and therapeutics","volume":"15","author":"Lu","year":"2022","journal-title":"J Inflammation Res"},{"key":"B202","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/j.jcmgh.2021.03.012","article-title":"Deep analysis of the peripheral immune system in IBD reveals new insight in disease subtyping and response to monotherapy or combination therapy","volume":"12","author":"Kosoy","year":"2021","journal-title":"Cell Mol Gastroenterol hepatology"},{"key":"B203","doi-asserted-by":"publisher","first-page":"108176","DOI":"10.1016\/j.pharmthera.2022.108176","article-title":"Macrophage immunometabolism in inflammatory bowel diseases: From pathogenesis to therapy","volume":"238","author":"Pan","year":"2022","journal-title":"Pharmacol Ther"},{"key":"B204","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.cmet.2022.02.015","article-title":"The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming","volume":"34","author":"Hochrein","year":"2022","journal-title":"Cell Metab"},{"key":"B205","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-0291-z","article-title":"Targeting immunometabolism as an anti-inflammatory strategy","volume":"30","author":"P\u00e5lsson-McDermott","year":"2020","journal-title":"Cell Res"},{"key":"B206","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1219422","article-title":"Mitochondrial dysfunctions in T cells: focus on inflammatory bowel disease","volume":"14","author":"Lee","year":"2023","journal-title":"Front Immunol"},{"key":"B207","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242317124","article-title":"Role of mitochondria in inflammatory bowel diseases: A systematic review","volume":"24","author":"S\u00e1nchez-Quintero","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B208","doi-asserted-by":"publisher","DOI":"10.3390\/cells12131779","article-title":"Autophagy in crohn\u2019s disease: converging on dysfunctional innate immunity","volume":"12","author":"Alula","year":"2023","journal-title":"Cells"},{"key":"B209","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2022.2039991","article-title":"The Crohn Disease-associated ATG16L1(T300A) polymorphism regulates inflammatory responses by modulating TLR- and NLR-mediated signaling","volume":"18","author":"Gao","year":"2022","journal-title":"Autophagy"},{"key":"B210","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad9948","article-title":"Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease","volume":"352","author":"Chu","year":"2016","journal-title":"Sci (New York NY)"},{"key":"B211","doi-asserted-by":"publisher","DOI":"10.3390\/nu12020347","article-title":"Galangin protects against symptoms of dextran sodium sulfate-induced acute colitis by activating autophagy and modulating the gut microbiota","volume":"12","author":"Xuan","year":"2020","journal-title":"Nutrients"},{"key":"B212","doi-asserted-by":"publisher","DOI":"10.3892\/etm","article-title":"Advanced glycation end products and lipopolysaccharides stimulate interleukin-6 secretion via the RAGE\/TLR4-NF-\u03baB-ROS pathways and resveratrol attenuates these inflammatory responses in mouse macrophages","volume":"14","author":"Ohtsu","year":"2017","journal-title":"Exp Ther Med"},{"key":"B213","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2016.03.022","article-title":"A SIRT3\/AMPK\/autophagy network orchestrates the protective effects of trans-resveratrol in stressed peritoneal macrophages and RAW 264.7 macrophages","volume":"95","author":"Duan","year":"2016","journal-title":"Free Radical Biol Med"},{"key":"B214","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1017\/S0007114515001415","article-title":"Favourable effects of grape seed extract on intestinal epithelial differentiation and barrier function in IL10-deficient mice","volume":"114","author":"Yang","year":"2015","journal-title":"Br J Nutr"},{"key":"B215","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S310952","article-title":"Current strategies and potential prospects of nanomedicine-mediated therapy in inflammatory bowel disease","volume":"16","author":"Chen","year":"2021","journal-title":"Int J nanomedicine"},{"key":"B216","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i21.6572","article-title":"Effect of resveratrol on Treg\/Th17 signaling and ulcerative colitis treatment in mice","volume":"21","author":"Yao","year":"2015","journal-title":"World J gastroenterology"},{"key":"B217","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202001502R","article-title":"Pterostilbene reduces colonic inflammation by suppressing dendritic cell activation and promoting regulatory T cell development","volume":"34","author":"Yashiro","year":"2020","journal-title":"FASEB J"},{"key":"B218","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.109.160838","article-title":"Resveratrol (trans-3,5,4\u2019-trihydroxystilbene) induces silent mating type information regulation-1 and down-regulates nuclear transcription factor-kappaB activation to abrogate dextran sulfate sodium-induced colitis","volume":"332","author":"Singh","year":"2010","journal-title":"J Pharmacol Exp Ther"},{"key":"B219","doi-asserted-by":"publisher","first-page":"104716","DOI":"10.1016\/j.jff.2021.104716","article-title":"Curcumin ameliorated dextran sulfate sodium-induced colitis via regulating the homeostasis of DCs and Treg and improving the composition of the gut microbiota","volume":"86","author":"Zhong","year":"2021","journal-title":"J Funct Foods"},{"key":"B220","doi-asserted-by":"publisher","first-page":"3334994","DOI":"10.1155\/2021\/3334994","article-title":"Curcumin alleviated dextran sulfate sodium-induced colitis by regulating M1\/M2 macrophage polarization and TLRs signaling pathway","volume":"2021","author":"Kang","year":"2021","journal-title":"Evidence-Based complementary Altern medicine: eCAM"},{"key":"B221","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2015.06.008","article-title":"Arctigenin exerts anti-colitis efficacy through inhibiting the differentiation of Th1 and Th17 cells via an mTORC1-dependent pathway","volume":"96","author":"Wu","year":"2015","journal-title":"Biochem Pharmacol"},{"key":"B222","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.926945","article-title":"Shikonin ameliorated mice colitis by inhibiting dimerization and tetramerization of PKM2 in macrophages","volume":"13","author":"Huang","year":"2022","journal-title":"Front Pharmacol"},{"key":"B223","doi-asserted-by":"publisher","first-page":"104169","DOI":"10.1016\/j.jff.2020.104169","article-title":"Prebiotic effect of dietary polyphenols: A systematic review","volume":"74","author":"Alves-Santos","year":"2020","journal-title":"J Funct Foods"},{"key":"B224","doi-asserted-by":"publisher","DOI":"10.1093\/advances\/nmaa104","article-title":"Roles of the polyphenol-gut microbiota interaction in alleviating colitis and preventing colitis-associated colorectal cancer","volume":"12","author":"Zhao","year":"2021","journal-title":"Adv Nutr (Bethesda Md)"},{"key":"B225","doi-asserted-by":"publisher","DOI":"10.1016\/S1095-6433(00)00183-5","article-title":"Short chain fatty acids but not lactate or succinate stimulate mucus release in the rat colon","volume":"125","author":"Shimotoyodome","year":"2000","journal-title":"Comp Biochem Physiol Part A Mol Integr Physiol"},{"key":"B226","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1322269111","article-title":"The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition","volume":"111","author":"Chang","year":"2014","journal-title":"Proc Natl Acad Sci United States America"},{"key":"B227","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izab024","article-title":"Targeting immune cell metabolism in the treatment of inflammatory bowel disease","volume":"27","author":"Zaiatz Bittencourt","year":"2021","journal-title":"Inflammatory bowel diseases"},{"key":"B228","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.nutres.2020.01.002","article-title":"Mango (Mangifera indica L.) polyphenols reduce IL-8, GRO, and GM-SCF plasma levels and increase Lactobacillus species in a pilot study in patients with inflammatory bowel disease","volume":"75","author":"Kim","year":"2020","journal-title":"Nutr Res (New York NY)"},{"key":"B229","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-384913-7.00001-0","article-title":"1 - Multiple Sclerosis: Pathophysiology, Clinical Features, Diagnosis, and Management","volume-title":"Neuroinflammation","author":"Maghzi","year":"2011"},{"key":"B230","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.657622","article-title":"ILC3, a central innate immune component of the gut-brain axis in multiple sclerosis","volume":"12","author":"Miljkovi\u0107","year":"2021","journal-title":"Front Immunol"},{"key":"B231","doi-asserted-by":"publisher","DOI":"10.1172\/JCI124012","article-title":"Enhanced glycolytic metabolism supports transmigration of brain-infiltrating macrophages in multiple sclerosis","volume":"129","author":"Kaushik","year":"2019","journal-title":"J Clin Invest"},{"key":"B232","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25998","article-title":"Involvement of the Warburg effect in non-tumor diseases processes","volume":"233","author":"Chen","year":"2018","journal-title":"J Cell Physiol"},{"key":"B233","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s12974-024-03016-8","article-title":"Mitochondrial and metabolic dysfunction of peripheral immune cells in multiple sclerosis","volume":"21","author":"Wang","year":"2024","journal-title":"J neuroinflammation"},{"key":"B234","doi-asserted-by":"publisher","DOI":"10.1093\/cei\/uxac017","article-title":"Autophagy modulation in multiple sclerosis and experimental autoimmune encephalomyelitis","volume":"209","author":"Shen","year":"2022","journal-title":"Clin Exp Immunol"},{"key":"B235","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.603710","article-title":"Autophagy in multiple sclerosis: two sides of the same coin","volume":"14","author":"Misrielal","year":"2020","journal-title":"Front Cell Neurosci"},{"key":"B236","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.639369","article-title":"Common peripheral immunity mechanisms in multiple sclerosis and alzheimer\u2019s disease","volume":"12","author":"Rossi","year":"2021","journal-title":"Front Immunol"},{"key":"B237","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1186\/s40478-014-0163-1","article-title":"Treg cells mediate recovery from EAE by controlling effector T cell proliferation and motility in the CNS","volume":"2","author":"Koutrolos","year":"2014","journal-title":"Acta neuropathologica Commun"},{"key":"B238","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1111\/jnc.15169","article-title":"Metabolic determinants of leukocyte pathogenicity in neurological diseases","volume":"158","author":"Runtsch","year":"2021","journal-title":"J neurochemistry"},{"key":"B239","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1186\/s12974-021-02194-z","article-title":"Phloretin suppresses neuroinflammation by autophagy-mediated Nrf2 activation in macrophages","volume":"18","author":"Dierckx","year":"2021","journal-title":"J neuroinflammation"},{"key":"B240","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.09.007","article-title":"Epigallocatechin-3-gallate ameliorates experimental autoimmune encephalomyelitis by altering balance among CD4+ T-cell subsets","volume":"180","author":"Wang","year":"2012","journal-title":"Am J pathology"},{"key":"B241","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2009.01.025","article-title":"Amelioration of experimental autoimmune encephalomyelitis by curcumin treatment through inhibition of IL-17 production","volume":"9","author":"Xie","year":"2009","journal-title":"Int immunopharmacology"},{"key":"B242","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.jneuroim.2016.11.009","article-title":"Hesperidin ameliorates immunological outcome and reduces neuroinflammation in the mouse model of multiple sclerosis","volume":"302","author":"Haghmorad","year":"2017","journal-title":"J neuroimmunology"},{"key":"B243","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2017.12.004","article-title":"Dietary naringenin supplementation attenuates experimental autoimmune encephalomyelitis by modulating autoimmune inflammatory responses in mice","volume":"54","author":"Wang","year":"2018","journal-title":"J Nutr Biochem"},{"key":"B244","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2013.02.002","article-title":"Curcumin induces apoptotic cell death of activated human CD4+ T cells via increasing endoplasmic reticulum stress and mitochondrial dysfunction","volume":"15","author":"Zheng","year":"2013","journal-title":"Int immunopharmacology"},{"key":"B245","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0075139","article-title":"Resveratrol Inhibits CD4+ T cell activation by enhancing the expression and activity of Sirt1","volume":"8","author":"Zou","year":"2013","journal-title":"PloS One"},{"key":"B246","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.5VMR0118-021RR","article-title":"Obesity and type 2 diabetes mellitus drive immune dysfunction, infection development, and sepsis\u00a0mortality","volume":"104","author":"Frydrych","year":"2018","journal-title":"J leukocyte Biol"},{"key":"B247","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.MR1218-478R","article-title":"Leptin in the regulation of the immunometabolism of adipose tissue-macrophages","volume":"106","author":"Monteiro","year":"2019","journal-title":"J leukocyte Biol"},{"key":"B248","doi-asserted-by":"publisher","DOI":"10.18632\/aging.v10i10","article-title":"Autophagy of macrophages is regulated by PI3k\/Akt\/mTOR signalling in the development of diabetic encephalopathy","volume":"10","author":"Wang","year":"2018","journal-title":"Aging"},{"key":"B249","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2020.03.004","article-title":"Mitochondria and T2D: role of autophagy, ER stress, and inflammasome","volume":"31","author":"Rocha","year":"2020","journal-title":"Trends Endocrinol metabolism: TEM"},{"key":"B250","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1980","article-title":"Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome","volume":"12","author":"Nakahira","year":"2011","journal-title":"Nat Immunol"},{"key":"B251","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23169252","article-title":"Macrophage polarization mediated by mitochondrial dysfunction induces adipose tissue inflammation in obesity","volume":"23","author":"Xu","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B252","doi-asserted-by":"publisher","DOI":"10.5534\/wjmh.200163","article-title":"Macrophage and adipocyte mitochondrial dysfunction in obesity-induced metabolic diseases","volume":"39","author":"Wang","year":"2021","journal-title":"World J men\u2019s Health"},{"key":"B253","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2016.6707","article-title":"Are mitochondrial fusion and fission impaired in leukocytes of type 2 diabetic patients","volume":"25","author":"Diaz-Morales","year":"2016","journal-title":"Antioxidants Redox Signaling"},{"key":"B254","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.932893","article-title":"Obesity-mediated immune modulation: one step forward, (Th)2 steps back","volume":"13","author":"Schmidt","year":"2022","journal-title":"Front Immunol"},{"key":"B255","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-017-4526-6","article-title":"Unique metabolic activation of adipose tissue macrophages in obesity promotes inflammatory responses","volume":"61","author":"Boutens","year":"2018","journal-title":"Diabetologia"},{"key":"B256","doi-asserted-by":"publisher","DOI":"10.3389\/fragi.2021.681428","article-title":"Altered nutrient uptake causes mitochondrial dysfunction in senescent CD8(+) EMRA T cells during type 2 diabetes","volume":"2","author":"Callender","year":"2021","journal-title":"Front aging"},{"key":"B257","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2019.1633235","article-title":"Metformin as an archetype immuno-metabolic adjuvant for cancer immunotherapy","volume":"8","author":"Verdura","year":"2019","journal-title":"Oncoimmunology"},{"key":"B258","doi-asserted-by":"publisher","first-page":"113787","DOI":"10.1016\/j.bcp.2019.113787","article-title":"Immune-mediated anti-tumor effects of metformin; targeting metabolic reprogramming of T cells as a new possible mechanism for anti-cancer effects of metformin","volume":"174","author":"Bahrambeigi","year":"2020","journal-title":"Biochem Pharmacol"},{"key":"B259","doi-asserted-by":"publisher","DOI":"10.1111\/1750-3841.14723","article-title":"Promotion of Mitochondrial Biogenesis via Activation of AMPK-PGC1\u03b1 Signaling Pathway by Ginger (Zingiber officinale Roscoe) Extract, and Its Major Active Component 6-Gingerol","volume":"84","author":"Deng","year":"2019","journal-title":"J Food sci"},{"key":"B260","doi-asserted-by":"publisher","DOI":"10.1111\/j.1752-8062.2011.00357.x","article-title":"Alterations in skeletal muscle indicators of mitochondrial structure and biogenesis in patients with type 2 diabetes and heart failure: effects of epicatechin rich cocoa","volume":"5","author":"Taub","year":"2012","journal-title":"Clin Trans sci"},{"key":"B261","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/1743-7075-11-32","article-title":"Sudachitin, a polymethoxylated flavone, improves glucose and lipid metabolism by increasing mitochondrial biogenesis in skeletal muscle","volume":"11","author":"Tsutsumi","year":"2014","journal-title":"Nutr Metab"},{"key":"B262","doi-asserted-by":"publisher","first-page":"1325307","DOI":"10.1080\/16546628.2017.1325307","article-title":"Effects of epigallocatechin-3-gallate on thermogenesis and mitochondrial biogenesis in brown adipose tissues of diet-induced obese mice","volume":"61","author":"Lee","year":"2017","journal-title":"Food Nutr Res"},{"key":"B263","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2011.03.014","article-title":"Enhanced autophagy plays a cardinal role in mitochondrial dysfunction in type 2 diabetic Goto-Kakizaki (GK) rats: ameliorating effects of (-)-epigallocatechin-3-gallate","volume":"23","author":"Yan","year":"2012","journal-title":"J Nutr Biochem"},{"key":"B264","doi-asserted-by":"publisher","first-page":"898","DOI":"10.3109\/10715762.2014.920955","article-title":"(-)-Epigallocatechin-3-gallate attenuated myocardial mitochondrial dysfunction and autophagy in diabetic Goto-Kakizaki rats","volume":"48","author":"Liu","year":"2014","journal-title":"Free Radical Res"},{"key":"B265","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24087422","article-title":"Effect of resveratrol on markers of oxidative stress and sirtuin 1 in elderly adults with type 2 diabetes","volume":"24","author":"Garc\u00eda-Mart\u00ednez","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B266","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2007.07.082","article-title":"Capsaicin, a spicy component of hot peppers, modulates adipokine gene expression and protein release from obese-mouse adipose tissues and isolated adipocytes, and suppresses the inflammatory responses of adipose tissue macrophages","volume":"581","author":"Kang","year":"2007","journal-title":"FEBS letters"},{"key":"B267","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200900026","article-title":"Purified berry anthocyanins but not whole berries normalize lipid parameters in mice fed an obesogenic high fat diet","volume":"53","author":"Prior","year":"2009","journal-title":"Mol Nutr Food Res"},{"key":"B268","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00106.2012","article-title":"Purple corn anthocyanins inhibit diabetes-associated glomerular monocyte activation and macrophage infiltration","volume":"303","author":"Kang","year":"2012","journal-title":"Am J Physiol Renal Physiol"},{"key":"B269","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2010.1367","article-title":"Dietary capsaicin attenuates metabolic dysregulation in genetically obese diabetic mice","volume":"14","author":"Kang","year":"2011","journal-title":"J medicinal Food"},{"key":"B270","doi-asserted-by":"publisher","DOI":"10.2337\/db11-0275","article-title":"Targeting curcusomes to inflammatory dendritic cells inhibits NF-\u03baB and improves insulin resistance in obese mice","volume":"60","author":"Yekollu","year":"2011","journal-title":"Diabetes"},{"key":"B271","doi-asserted-by":"publisher","first-page":"18056","DOI":"10.1038\/s41598-018-37157-7","article-title":"Propolis-based niosomes as oromuco-adhesive films: A randomized clinical trial of a therapeutic drug delivery platform for the treatment of oral recurrent aphthous ulcers","volume":"8","author":"Arafa","year":"2018","journal-title":"Sci Rep"},{"key":"B272","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10123045","article-title":"Phenolic Compounds Known to Be Present in Lingonberry (Vaccinium vitis-idaea L.) Enhance Macrophage Polarization towards the Anti-Inflammatory M2 Phenotype","volume":"10","author":"Ryyti","year":"2022","journal-title":"Biomedicines"},{"key":"B273","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-021-15829-8","article-title":"Quercetin improves the adipose inflammatory response and insulin signaling to reduce \u201creal-world\u201d particulate matter-induced insulin resistance","volume":"29","author":"Jiang","year":"2022","journal-title":"Environ Sci pollut Res Int"},{"key":"B274","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201900995","article-title":"Red Raspberry Polyphenols Attenuate High-Fat Diet-Driven Activation of NLRP3 Inflammasome and its Paracrine Suppression of Adipogenesis via Histone Modifications","volume":"64","author":"Fan","year":"2020","journal-title":"Mol Nutr Food Res"},{"key":"B275","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2015.08.011","article-title":"Green tea polyphenols change the profile of inflammatory cytokine release from lymphocytes of obese and lean rats and protect against oxidative damage","volume":"28","author":"Molina","year":"2015","journal-title":"Int immunopharmacology"},{"key":"B276","doi-asserted-by":"publisher","DOI":"10.1108\/NFS-05-2019-0165","article-title":"Traditional drink of black cincau (Mesona palustris BL)-based wedang uwuh as immunomodulator on alloxan-induced diabetic rats","volume":"50","author":"Widyaningsih","year":"2020","journal-title":"Nutr Food Sci"},{"key":"B277","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.jff.2015.02.017","article-title":"Procyanidins and docosahexaenoic acid suppress inflammation and boost immune system in cafeteria diet-fed rats","volume":"15","author":"Martinez-Micaelo","year":"2015","journal-title":"J Funct Foods"},{"key":"B278","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2013.11.006","article-title":"Epigallocatechin-3-gallate ameliorates both obesity and autoinflammatory arthritis aggravated by obesity by altering the balance among CD4+ T-cell subsets","volume":"157","author":"Byun","year":"2014","journal-title":"Immunol Lett"},{"key":"B279","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2014.09.008","article-title":"The role of the immune system in neurodegenerative disorders: Adaptive or maladaptive","volume":"1617","author":"Doty","year":"2015","journal-title":"Brain Res"},{"key":"B280","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.872134","article-title":"The emerging role of central and peripheral immune systems in neurodegenerative diseases","volume":"14","author":"Zang","year":"2022","journal-title":"Front Aging Neurosci"},{"key":"B281","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1525466113","article-title":"The adaptive immune system restrains Alzheimer\u2019s disease pathogenesis by modulating microglial function","volume":"113","author":"Marsh","year":"2016","journal-title":"Proc Natl Acad Sci United States America"},{"key":"B282","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1038\/s41467-021-22479-4","article-title":"Therapeutic B-cell depletion reverses progression of Alzheimer\u2019s disease","volume":"12","author":"Kim","year":"2021","journal-title":"Nat Commun"},{"key":"B283","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0998-21.2022","article-title":"Neuroimmunometabolism: A new pathological nexus underlying neurodegenerative disorders","volume":"42","author":"Mitra","year":"2022","journal-title":"J neuroscience: Off J Soc Neurosci"},{"key":"B284","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-022-00879-6","article-title":"Mitochondrial-derived damage-associated molecular patterns amplify neuroinflammation in neurodegenerative diseases","volume":"43","author":"Lin","year":"2022","journal-title":"Acta pharmacologica Sinica"},{"key":"B285","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201899430","article-title":"Beclin1-driven autophagy modulates the inflammatory response of microglia via NLRP3","volume":"38","author":"Houtman","year":"2019","journal-title":"EMBO J"},{"key":"B286","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-05788-0","article-title":"Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy","volume":"615","author":"Chen","year":"2023","journal-title":"Nature"},{"key":"B287","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.v7i33","article-title":"Immunomodulation by memantine in therapy of Alzheimer\u2019s disease is mediated through inhibition of Kv1.3 channels and T cell responsiveness","volume":"7","author":"Lowinus","year":"2016","journal-title":"Oncotarget"},{"key":"B288","doi-asserted-by":"publisher","first-page":"5010741","DOI":"10.1155\/2018\/5010741","article-title":"Benefit of oleuropein aglycone for alzheimer\u2019s disease by promoting autophagy","volume":"2018","author":"Cordero","year":"2018","journal-title":"Oxid Med Cell longevity"},{"key":"B289","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.v6i34","article-title":"Oleuropein aglycone induces autophagy via the AMPK\/mTOR signalling pathway: a mechanistic insight","volume":"6","author":"Rigacci","year":"2015","journal-title":"Oncotarget"},{"key":"B290","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2014.06.051","article-title":"Downregulation of PI3K\/Akt\/mTOR signaling pathway in curcumin-induced autophagy in APP\/PS1 double transgenic mice","volume":"740","author":"Wang","year":"2014","journal-title":"Eur J Pharmacol"},{"key":"B291","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2011.07594.x","article-title":"Resveratrol mitigates lipopolysaccharide- and A\u03b2-mediated microglial inflammation by inhibiting the TLR4\/NF-\u03baB\/STAT signaling cascade","volume":"120","author":"Capiralla","year":"2012","journal-title":"J neurochemistry"},{"key":"B292","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2017.03.003","article-title":"Resveratrol regulates microglia M1\/M2 polarization via PGC-1\u03b1 in conditions of neuroinflammatory injury","volume":"64","author":"Yang","year":"2017","journal-title":"Brain behavior immunity"},{"key":"B293","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12974-016-0779-0","article-title":"Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer\u2019s disease","volume":"14","author":"Moussa","year":"2017","journal-title":"J neuroinflammation"},{"key":"B294","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-017-0798-6","article-title":"Natural dietary supplementation of anthocyanins via PI3K\/akt\/nrf2\/HO-1 pathways mitigate oxidative stress, neurodegeneration, and memory impairment in a mouse model of alzheimer\u2019s disease","volume":"55","author":"Ali","year":"2018","journal-title":"Mol neurobiology"},{"key":"B295","doi-asserted-by":"publisher","first-page":"36","DOI":"10.3390\/antiox9010036","article-title":"Hydroxytyrosol decreases LPS- and \u03b1-synuclein-induced microglial activation in vitro","volume":"9","author":"Gallardo-Fern\u00e1ndez","year":"2019","journal-title":"Antioxidants (Basel Switzerland)"},{"key":"B296","doi-asserted-by":"publisher","DOI":"10.1111\/cns.13086","article-title":"Baicalin mitigates cognitive impairment and protects neurons from microglia-mediated neuroinflammation via suppressing NLRP3 inflammasomes and TLR4\/NF-\u03baB signaling pathway","volume":"25","author":"Jin","year":"2019","journal-title":"CNS Neurosci Ther"},{"key":"B297","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201100262","article-title":"Gallic acid, a histone acetyltransferase inhibitor, suppresses \u03b2-amyloid neurotoxicity by inhibiting microglial-mediated neuroinflammation","volume":"55","author":"Kim","year":"2011","journal-title":"Mol Nutr Food Res"},{"key":"B298","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.mito.2023.10.003","article-title":"Mitochondrial dysfunction and inflammasome activation in neurodegenerative diseases: Mechanisms and therapeutic implications","volume":"73","author":"Hamzeh","year":"2023","journal-title":"Mitochondrion"},{"key":"B299","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/s41531-017-0032-2","article-title":"Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson\u2019s disease","volume":"3","author":"Sarkar","year":"2017","journal-title":"NPJ Parkinson\u2019s disease"},{"key":"B300","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2020.10.010","article-title":"Impaired autophagy in microglia aggravates dopaminergic neurodegeneration by regulating NLRP3 inflammasome activation in experimental models of Parkinson\u2019s disease","volume":"91","author":"Qin","year":"2021","journal-title":"Brain behavior immunity"},{"key":"B301","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00160","article-title":"Partial depletion of peripheral M1 macrophages reverses motor deficits in MPTP-treated mouse by suppressing neuroinflammation and dopaminergic neurodegeneration","volume":"10","author":"Yan","year":"2018","journal-title":"Front Aging Neurosci"},{"key":"B302","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0183484","article-title":"Carbidopa, a drug in use for management of Parkinson disease inhibits T cell activation and autoimmunity","volume":"12","author":"Zhu","year":"2017","journal-title":"PloS One"},{"key":"B303","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.stem.2018.06.015","article-title":"Th17 lymphocytes induce neuronal cell death in a human iPSC-based model of parkinson\u2019s disease","volume":"23","author":"Sommer","year":"2018","journal-title":"Cell Stem Cell"},{"key":"B304","doi-asserted-by":"publisher","DOI":"10.1177\/1753425913488429","article-title":"Neuroprotective effects of resveratrol in an MPTP mouse model of Parkinson\u2019s-like disease: possible role of SOCS-1 in reducing pro-inflammatory responses","volume":"20","author":"Lofrumento","year":"2014","journal-title":"Innate immunity"},{"key":"B305","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-008-9675-z","article-title":"Curcumin protects dopaminergic neuron against LPS induced neurotoxicity in primary rat neuron\/glia culture","volume":"33","author":"Yang","year":"2008","journal-title":"Neurochemical Res"},{"key":"B306","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-012-9431-7","article-title":"Curcumin ameliorates the neurodegenerative pathology in A53T \u03b1-synuclein cell model of Parkinson\u2019s disease through the downregulation of mTOR\/p70S6K signaling and the recovery of macroautophagy","volume":"8","author":"Jiang","year":"2013","journal-title":"J neuroimmune Pharmacol"},{"key":"B307","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2022.07.014","article-title":"Nanopolyphenol rejuvenates microglial surveillance of multiple misfolded proteins through metabolic reprogramming","volume":"13","author":"Wang","year":"2023","journal-title":"Acta Pharm Sin B"},{"key":"B308","doi-asserted-by":"publisher","first-page":"2856063","DOI":"10.1155\/2018\/2856063","article-title":"Mangiferin and morin attenuate oxidative stress, mitochondrial dysfunction, and neurocytotoxicity, induced by amyloid beta oligomers","volume":"2018","author":"Alberdi","year":"2018","journal-title":"Oxid Med Cell longevity"},{"key":"B309","doi-asserted-by":"publisher","DOI":"10.18632\/aging.v13i8","article-title":"Administration of quercetin improves mitochondria quality control and protects the neurons in 6-OHDA-lesioned Parkinson\u2019s disease models","volume":"13","author":"Wang","year":"2021","journal-title":"Aging"},{"key":"B310","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200502280-00013","article-title":"Genistein protects dopaminergic neurons by inhibiting microglial activation","volume":"16","author":"Wang","year":"2005","journal-title":"Neuroreport"},{"key":"B311","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23042031","article-title":"Chicoric acid prevents neuroinflammation and neurodegeneration in a mouse parkinson\u2019s disease model: immune response and transcriptome profile of the spleen and colon","volume":"23","author":"Wang","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B312","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/imcb.12191","article-title":"The immune system and stroke: from current targets to future therapy","volume":"97","author":"Malone","year":"2019","journal-title":"Immunol Cell Biol"},{"key":"B313","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.911661","article-title":"Systemic immune responses after ischemic stroke: From the center to the periphery","volume":"13","author":"Wu","year":"2022","journal-title":"Front Immunol"},{"key":"B314","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3934\/medsci.2017.1.1","article-title":"Is stroke a neurodegenerative condition? A critical review of secondary neurodegeneration and amyloid-beta accumulation after stroke","volume":"4","author":"Ong","year":"2017","journal-title":"AIMS Med Science"},{"key":"B315","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.3590","article-title":"Brain-immune interactions and ischemic stroke: clinical implications","volume":"69","author":"Kamel","year":"2012","journal-title":"Arch neurology"},{"key":"B316","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X221098841","article-title":"Microglial phagocytosis and regulatory mechanisms after stroke","volume":"42","author":"Chen","year":"2022","journal-title":"J Cereb Blood Flow Metab"},{"key":"B317","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12361","article-title":"Mitochondrial dynamics modulate the expression of pro-inflammatory mediators in microglial cells","volume":"127","author":"Park","year":"2013","journal-title":"J neurochemistry"},{"key":"B318","doi-asserted-by":"publisher","first-page":"4335272","DOI":"10.1155\/2022\/4335272","article-title":"M1 microglia induced neuronal injury on ischemic stroke via mitochondrial crosstalk between microglia and neurons","volume":"2022","author":"Liu","year":"2022","journal-title":"Oxid Med Cell longevity"},{"key":"B319","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.274331","article-title":"Autophagy and inflammation in ischemic stroke","volume":"15","author":"Mo","year":"2020","journal-title":"Neural regeneration Res"},{"key":"B320","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2015.02.003","article-title":"Hypoxia induces microglia autophagy and neural inflammation injury in focal cerebral ischemia model","volume":"98","author":"Yang","year":"2015","journal-title":"Exp Mol pathology"},{"key":"B321","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2023.2165313","article-title":"Microglial phagocytosis dysfunction in stroke is driven by energy depletion and induction of autophagy","volume":"19","author":"Beccari","year":"2023","journal-title":"Autophagy"},{"key":"B322","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphs.2020.11.007","article-title":"Microglial metabolic disturbances and neuroinflammation in cerebral infarction","volume":"145","author":"Takeda","year":"2021","journal-title":"J Pharmacol Sci"},{"key":"B323","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1111\/jnc.14267","article-title":"Hexokinase 2-dependent hyperglycolysis driving microglial activation contributes to ischemic brain injury","volume":"144","author":"Li","year":"2018","journal-title":"J neurochemistry"},{"key":"B324","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2015.144","article-title":"Immune interventions in stroke","volume":"11","author":"Fu","year":"2015","journal-title":"Nat Rev Neurology"},{"key":"B325","doi-asserted-by":"publisher","first-page":"212553","DOI":"10.7573\/dic.212553","article-title":"The therapeutic role of minocycline in Parkinson\u2019s disease","volume":"8","author":"Cankaya","year":"2019","journal-title":"Drugs context"},{"key":"B326","doi-asserted-by":"publisher","first-page":"114464","DOI":"10.1016\/j.bcp.2021.114464","article-title":"Minocycline promotes functional recovery in ischemic stroke by modulating microglia polarization through STAT1\/STAT6 pathways","volume":"186","author":"Lu","year":"2021","journal-title":"Biochem Pharmacol"},{"key":"B327","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.109.202044","article-title":"Plasmin triggers chemotaxis of monocyte-derived dendritic cells through an Akt2-dependent pathway and promotes a T-helper type-1 response","volume":"30","author":"Li","year":"2010","journal-title":"Arteriosclerosis thrombosis Vasc Biol"},{"key":"B328","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21197014","article-title":"Recombinant tissue plasminogen activator (r-tPA) induces in-vitro human neutrophil migration via low density lipoprotein receptor-related protein 1 (LRP-1)","volume":"21","author":"Liberale","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B329","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2011.189","article-title":"The flavonoid fisetin attenuates postischemic immune cell infiltration, activation and infarct size after transient cerebral middle artery occlusion in mice","volume":"32","author":"Gelderblom","year":"2012","journal-title":"J Cereb Blood Flow Metab"},{"key":"B330","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2016.12.012","article-title":"Pinocembrin protects hemorrhagic brain primarily by inhibiting toll-like receptor 4 and reducing M1 phenotype microglia","volume":"61","author":"Lan","year":"2017","journal-title":"Brain behavior immunity"},{"key":"B331","doi-asserted-by":"publisher","DOI":"10.1002\/(ISSN)1097-4547","article-title":"Neuroprotective mechanisms of curcumin against cerebral ischemia-induced neuronal apoptosis and behavioral deficits","volume":"82","author":"Wang","year":"2005","journal-title":"J Neurosci Res"},{"key":"B332","doi-asserted-by":"publisher","first-page":"147626","DOI":"10.1016\/j.brainres.2021.147626","article-title":"Baicalein ameliorates ischemic brain damage through suppressing proinflammatory microglia polarization via inhibiting the TLR4\/NF-\u03baB and STAT1 pathway","volume":"1770","author":"Ran","year":"2021","journal-title":"Brain Res"},{"key":"B333","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1080\/1547691X.2022.2043494","article-title":"Gallic acid attenuates cerebral ischemia\/re-perfusion-induced blood\u2013brain barrier injury by modifying polarization of microglia","volume":"19","author":"Qu","year":"2022","journal-title":"J\u00a0Immunotoxicology"},{"key":"B334","doi-asserted-by":"publisher","first-page":"2461079","DOI":"10.1155\/2020\/2461079","article-title":"Kaempferol protects cell damage in in vitro ischemia reperfusion model in rat neuronal PC12 cells","volume":"2020","author":"Zhou","year":"2020","journal-title":"BioMed Res Int"},{"key":"B335","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-019-00687-3","article-title":"Neuroprotection of resveratrol against focal cerebral ischemia\/reperfusion injury in mice through a mechanism targeting gut-brain axis","volume":"39","author":"Dou","year":"2019","journal-title":"Cell Mol neurobiology"},{"key":"B336","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903002","article-title":"Metabolic shifts in immunity and inflammation","volume":"184","author":"Kominsky","year":"2010","journal-title":"J Immunol (Baltimore Md: 1950)"},{"key":"B337","first-page":"95","article-title":"Importance of nutrients and nutrient metabolism on human health","volume":"91","author":"Chen","year":"2018","journal-title":"Yale J Biol Med"},{"key":"B338","doi-asserted-by":"publisher","DOI":"10.3390\/nu5072314","article-title":"Modulation of immune function by polyphenols: possible contribution of epigenetic factors","volume":"5","author":"Cuevas","year":"2013","journal-title":"Nutrients"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2024.1360065\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T04:42:54Z","timestamp":1710477774000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2024.1360065\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,15]]},"references-count":338,"alternative-id":["10.3389\/fimmu.2024.1360065"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2024.1360065","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,15]]},"article-number":"1360065"}}