{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T10:29:38Z","timestamp":1769768978399,"version":"3.49.0"},"reference-count":76,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:00:00Z","timestamp":1728864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Despite being a bacterial pathogen with devastating consequences, <jats:italic>Tenacibaculum maritimum<\/jats:italic>\u2019s pathogenesis is not fully understood. The aim of the present study was to elucidate if different inoculation routes (intraperitoneal - i.p - injection and bath challenge - known to induce mortality) can induce tenacibaculosis (i.e., using the same <jats:italic>T. maritimum<\/jats:italic> inoculum), as well as evaluate the short-term immune response of European sea bass (<jats:italic>D. labrax<\/jats:italic>). Additionally, the host response against i.p. injection of extracellular products (ECPs) was also studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fish were i.p. challenged with 5.5 \u00d7 10<jats:sup>5<\/jats:sup> CFU mL<jats:sup>-1<\/jats:sup> of <jats:italic>T. maritimum<\/jats:italic> cells with or without ECPs (BECPs and BWO, respectively), ECPs alone or marine broth (mock). Another group of fish was bath-challenged with 5.5 \u00d7 10<jats:sup>5<\/jats:sup> CFU mL<jats:sup>-1<\/jats:sup> to confirm the virulence of the bacterial inoculum. Undisturbed specimens were used as controls. The severity of both challenges was determined by following percentage survival. Blood, liver and head-kidney samples were collected at 0, 3, 6, 24 and 48\u00a0h post-challenge for assessing immune parameters, oxidative stress and gene expression. Total and differential peritoneal cell counts were performed. The presence of viable bacteria in the blood and peritoneal cavity was studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Symptoms of tenacibaculosis, such as skin\/fin abrasions, were only observed in the bath-challenged fish, where 0% survival was recorded, whereas 100% survival was observed after i.p. injection of the same bacterial inoculum. An increase in total leukocyte numbers in the peritoneal cavity was observed 3\u00a0h post-injection of BECPs when compared to the other treatments. Blood total leukocytes, lymphocytes, and thrombocyte numbers dropped after the challenge, mainly in fish challenged with BECPs. At 48\u00a0h post-challenge, bactericidal activity in the plasma increased in fish injected with bacteria (with and without ECPs). The same tendency was seen for some of the oxidative stress parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion\/Conclusions<\/jats:title><jats:p>The increased expression of <jats:italic>il1\u03b2<\/jats:italic>, <jats:italic>il6, il8, and hamp1<\/jats:italic> in fish challenged with ECPs and BECPs suggests a more exacerbated pro-inflammatory response in the head-kidney against these inocula. The infection trial and the observed immune responses showed that the infection route is a determinant factor regarding <jats:italic>T. maritimum<\/jats:italic>-induced pathogenesis in European sea bass.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fimmu.2024.1478241","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T04:28:54Z","timestamp":1728880134000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Tenacibaculum maritimum can boost inflammation in Dicentrarchus labrax upon peritoneal injection but cannot trigger tenacibaculosis disease"],"prefix":"10.3389","volume":"15","author":[{"given":"In\u00eas A.","family":"Ferreira","sequence":"first","affiliation":[]},{"given":"Paulo","family":"Santos","sequence":"additional","affiliation":[]},{"given":"Javier Sanz","family":"Mox\u00f3","sequence":"additional","affiliation":[]},{"given":"Carla","family":"Teixeira","sequence":"additional","affiliation":[]},{"given":"Ana","family":"do Vale","sequence":"additional","affiliation":[]},{"given":"Benjamin","family":"Costas","sequence":"additional","affiliation":[]}],"member":"1965","published-online":{"date-parts":[[2024,10,14]]},"reference":[{"key":"B1","first-page":"1","article-title":"Vaccines for infectious bacterial and viral diseases of fish","volume":"2","author":"Shefat","year":"2018","journal-title":"J Bacteriology Infect Dis"},{"key":"B2","doi-asserted-by":"publisher","first-page":"26","DOI":"10.20546\/IJCMAS.2018.708.004","article-title":"Issues of antibiotic resistance in aquaculture industry and its way forward","volume":"7","author":"Aich","year":"2018","journal-title":"Int J Curr Microbiol Appl Sci"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3389\/FMICB.2017.00121","article-title":"The promise of whole genome pathogen sequencing for the molecular epidemiology of emerging aquaculture pathogens","volume":"8","author":"Bayliss","year":"2017","journal-title":"Front Microbiol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1093\/FEMSEC\/FIX161","article-title":"Exploring fish microbial communities to mitigate emerging diseases in aquaculture","volume":"94","author":"de Bruijn","year":"2018","journal-title":"FEMS Microbiol Ecol"},{"key":"B5","article-title":"Mass Mortalities in Mari-Cultured European Sea Bass (Dicentrarchus labrax) at Northern Egypt","author":"Moustafa","year":"2014","journal-title":"Res J Pharmaceutical Biol Chem Sci"},{"key":"B6","article-title":"Investigations into the Potential Causes of Mass Kills in Mari-Cultured Gilthead Sea Bream (Sparus aurata) at Northern Egypt. 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