{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T17:24:40Z","timestamp":1775841880778,"version":"3.50.1"},"reference-count":137,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T00:00:00Z","timestamp":1692835200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>Arsenic (As) is a toxic heavy metal widely found in the environment that severely undermines the integrity of water resources. Bioremediation of toxic compounds is an appellative sustainable technology with a balanced cost-effective setup. To pave the way for the potential use of <jats:italic>Deinococcus indicus,<\/jats:italic> an arsenic resistant bacterium, as a platform for arsenic bioremediation, an extensive characterization of its resistance to cellular insults is paramount. A comparative analysis of <jats:italic>D. indicus<\/jats:italic> cells grown in two rich nutrient media conditions (M53 and TGY) revealed distinct resistance patterns when cells are subjected to stress via UV-C and methyl viologen (MV). Cells grown in M53 demonstrated higher resistance to both UV-C and MV. Moreover, cells grow to higher density upon exposure to 25\u2009mM As(V) in M53 in comparison with TGY. This analysis is pivotal for the culture of microbial species in batch culture bioreactors for bioremediation purposes. We also demonstrate for the first time the presence of polyphosphate granules in <jats:italic>D. indicus<\/jats:italic> which are also found in a few <jats:italic>Deinococcus<\/jats:italic> species. To extend our analysis, we also characterized <jats:italic>Di<\/jats:italic>ArsC2 (arsenate reductase) involved in arsenic detoxification and structurally determined different states, revealing the structural evidence for a catalytic cysteine triple redox system. These results contribute for our understanding into the <jats:italic>D. indicus<\/jats:italic> resistance mechanism against stress conditions.<\/jats:p>","DOI":"10.3389\/fmicb.2023.1240798","type":"journal-article","created":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T11:07:01Z","timestamp":1692875221000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Unraveling the multifaceted resilience of arsenic resistant bacterium Deinococcus indicus"],"prefix":"10.3389","volume":"14","author":[{"given":"Andr\u00e9 G.","family":"Gouveia","sequence":"first","affiliation":[]},{"given":"Bruno A.","family":"Salgueiro","sequence":"additional","affiliation":[]},{"given":"Dean O.","family":"Ranmar","sequence":"additional","affiliation":[]},{"given":"Wilson D. T.","family":"Antunes","sequence":"additional","affiliation":[]},{"given":"Peter","family":"Kirchweger","sequence":"additional","affiliation":[]},{"given":"Ofra","family":"Golani","sequence":"additional","affiliation":[]},{"given":"Sharon G.","family":"Wolf","sequence":"additional","affiliation":[]},{"given":"Michael","family":"Elbaum","sequence":"additional","affiliation":[]},{"given":"Pedro M.","family":"Matias","sequence":"additional","affiliation":[]},{"given":"C\u00e9lia V.","family":"Rom\u00e3o","sequence":"additional","affiliation":[]}],"member":"1965","published-online":{"date-parts":[[2023,8,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1107\/S0907444909052925","article-title":"PHENIX: A comprehensive Python-based system for macromolecular structure solution","volume":"66","author":"Adams","year":"2010","journal-title":"Acta Crystallogr. Sect. D Biol. 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