{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T12:56:58Z","timestamp":1774011418134,"version":"3.50.1"},"reference-count":73,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T00:00:00Z","timestamp":1729728000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Although the oral cavity and the gut are anatomically continuous regions of the gastrointestinal tract, research on the relationship between oral and gut microbiota remains sparse. Oral-gut bacterial translocation is mostly studied in pathological contexts, thus evidence of translocation in healthy conditions is still scarce. Studying the oral-gut microbiota relationship in humans in different life stages is necessary in order to understand how these microbial communities might relate throughout life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, saliva and fecal samples were collected from healthy participants (39 children, 97 adults). Microbiota analysis was carried out by sequencing the V4 region of the 16S ribosomal RNA gene, followed by amplicon sequence variant (ASV) analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and discussion<\/jats:title><jats:p>Although the oral and gut microbiota are vastly different, a subset of 61 ASVs were present in both the oral cavity and gut of the same individual, and represented 1.6% of all ASVs detected. From these, 26 ASVs (classified into 18 genera: <jats:italic>Actinomyces<\/jats:italic>, <jats:italic>Rothia<\/jats:italic>, <jats:italic>Bacteroides<\/jats:italic>, <jats:italic>Porphyromonas<\/jats:italic>, <jats:italic>Prevotella<\/jats:italic>, <jats:italic>Alistipes<\/jats:italic>, <jats:italic>Fusobacterium<\/jats:italic>, <jats:italic>Neisseria<\/jats:italic>, <jats:italic>Haemophilus<\/jats:italic>, <jats:italic>Akkermansia<\/jats:italic>, <jats:italic>Solobacterium<\/jats:italic>, <jats:italic>Granulicatella<\/jats:italic>, <jats:italic>Streptococcus<\/jats:italic>, <jats:italic>Gemella<\/jats:italic>, <jats:italic>Mogibacterium<\/jats:italic>, <jats:italic>Dialister<\/jats:italic>, <jats:italic>Veillonella<\/jats:italic>, <jats:italic>Christensenellaceae R-7 group<\/jats:italic>) were present in both children and adults, suggesting the possibility of persistent colonization of both habitats by these microorganisms, initiating in childhood. Additionally, 62% of shared ASVs were more abundant in the oral cavity, indicating that oral-to-gut translocation may be the main route of translocation between environments, and highlighting that this phenomenon might be more common than previously thought in healthy individuals of all ages.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmicb.2024.1475159","type":"journal-article","created":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T08:31:41Z","timestamp":1729758701000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["The oral-gut microbiota relationship in healthy humans: identifying shared bacteria between environments and age groups"],"prefix":"10.3389","volume":"15","author":[{"given":"Carolina F. F. 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Dis."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.1126\/SCIENCE.1104816","article-title":"Host-bacterial mutualism in the human intestine","volume":"307","author":"B\u00e4ckhed","year":"2005","journal-title":"Science"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/NU12123759","article-title":"The gut microbiome, aging, and longevity: a systematic review","volume":"12","author":"Badal","year":"2020","journal-title":"Nutrients"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1038\/s41579-023-00963-6","article-title":"The oral microbiome: diversity, biogeography and human health","volume":"22","author":"Baker","year":"2024","journal-title":"Nat. Rev. Microbiol."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"e15254","DOI":"10.14814\/PHY2.15254","article-title":"Obesity influences composition of salivary and fecal microbiota and impacts the interactions between bacterial taxa","volume":"10","author":"Bombin","year":"2022","journal-title":"Physiol. Rep."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1168731","DOI":"10.3389\/FSPOR.2023.1168731","article-title":"Growing old together: what we know about the influence of diet and exercise on the aging host\u2019s gut microbiome","volume":"5","author":"Brooks","year":"2023","journal-title":"Front Sports Act Living"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"nzz040.P20-030-19","DOI":"10.1093\/CDN\/NZZ040.P20-030-19","article-title":"A citizen science project: associations of the Oral microbiota with body mass index and measures of sweet taste liking (P20-030-19)","volume":"3","author":"Bu","year":"2019","journal-title":"Curr. Dev. Nutr."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-020-59016-0","article-title":"Patterns of Oral microbiota diversity in adults and children: a crowdsourced population study","volume":"10","author":"Burcham","year":"2020","journal-title":"Sci. Rep."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1038\/nmeth.3869","article-title":"DADA2: high-resolution sample inference from Illumina amplicon data","volume":"13","author":"Callahan","year":"2016","journal-title":"Nat. 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Dent."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1002\/IID3.266","article-title":"Relationship between oral and gut microbiota in elderly people","volume":"7","author":"Iwauchi","year":"2019","journal-title":"Immun. Inflamm. Dis."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1177\/00220345231160747","article-title":"High-resolution detection of translocation of oral bacteria to the gut","volume":"102","author":"Kageyama","year":"2023","journal-title":"J. Dent. Res."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"3464","DOI":"10.1007\/S00203-023-03464-5","article-title":"Oral microbiome variations related to ageing: possible implications beyond oral health","volume":"205","author":"Kazarina","year":"2023","journal-title":"Arch. Microbiol."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"356589","DOI":"10.3389\/FMICB.2018.01835\/BIBTEX","article-title":"The human gut microbiome - a potential controller of wellness and disease","volume":"9","author":"Kho","year":"2018","journal-title":"Front. Microbiol."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/J.TMA.2020.07.004","article-title":"The microbiome: an emerging key player in aging and longevity","volume":"4","author":"Kim","year":"2020","journal-title":"Transl. Med. 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Microbiol."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s13105-020-00757-x","article-title":"Gender-associated differences in oral microbiota and salivary biochemical parameters in response to feeding","volume":"77","author":"Minty","year":"2021","journal-title":"J. Physiol. Biochem."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1111\/J.1749-6632.1993.TB18343.X","article-title":"Methods for collecting saliva","volume":"694","author":"Navazesh","year":"1993","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1186\/S12866-016-0708-5","article-title":"Age-related changes in gut microbiota composition from newborn to centenarian: a cross-sectional study","volume":"16","author":"Odamaki","year":"2016","journal-title":"BMC Microbiol."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"2124","DOI":"10.3390\/CANCERS13092124","article-title":"Oral\u2013gut microbiome Axis in gastrointestinal disease and cancer","volume":"13","author":"Park","year":"2021","journal-title":"Cancers"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1093\/BIOINFORMATICS\/BTQ041","article-title":"Identifying biologically relevant differences between metagenomic communities","volume":"26","author":"Parks","year":"2010","journal-title":"Bioinformatics"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"e00273-22","DOI":"10.1128\/MSYSTEMS.00273-22\/FORMAT\/EPUB","article-title":"Menopause is associated with an altered gut microbiome and estrobolome, with implications for adverse cardiometabolic risk in the Hispanic community health study\/study of Latinos","volume":"7","author":"Peters","year":"","journal-title":"mSystems"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.2147\/IJWH.S340491","article-title":"Spotlight on the gut microbiome in menopause: current insights","volume":"14","author":"Peters","year":"","journal-title":"Int. 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Syst."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1097\/MOG.0000000000000139","article-title":"The gut microbiome in health and in disease","volume":"31","author":"Shreiner","year":"2015","journal-title":"Curr. Opin. Gastroenterol."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"1971","DOI":"10.1002\/IBD.21606","article-title":"Invasive potential of gut mucosa-derived Fusobacterium nucleatum positively correlates with IBD status of the host","volume":"17","author":"Strauss","year":"2011","journal-title":"Inflamm. Bowel Dis."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.1042\/BCJ20160510","article-title":"Introduction to the human gut microbiota","volume":"474","author":"Thursby","year":"2017","journal-title":"Biochem. J."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"8692","DOI":"10.1038\/S41598-019-45198-9","article-title":"Neonatal oral fluid as a transmission route for bifidobacteria to the infant gut immediately after birth","volume":"9","author":"Toda","year":"2019","journal-title":"Sci. Rep."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"22086","DOI":"10.1038\/S41598-022-26528-W","article-title":"Analysis of the oral microbiome during hormonal cycle and its alterations in menopausal women: the \u201cAMICA\u201d project","volume":"12","author":"Tramice","year":"2022","journal-title":"Sci. Rep."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"1225875","DOI":"10.3389\/fnins.2023.1225875","article-title":"The gut microbiota\u2013brain axis in neurological disorder","volume":"17","author":"Ullah","year":"2023","journal-title":"Front. 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