{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T03:06:27Z","timestamp":1773198387848,"version":"3.50.1"},"reference-count":58,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002301","name":"Eesti Teadusagentuur","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002301","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006598","name":"Ettev\u00f5tluse Arendamise Sihtasutus","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006598","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Biological ageing is associated with physiological changes, including alterations in the gut microbiota. Lactobacilli may contribute to host health and longevity, yet their composition and functional properties in centenarians remain poorly characterized. The present study aimed to compare cultured intestinal lactobacilli from centenarians and young adults and to identify strains with potential probiotic properties.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Fecal samples were obtained from centenarians (\n                      <jats:italic>n<\/jats:italic>\n                      = 25) and young adults (\n                      <jats:italic>n<\/jats:italic>\n                      = 25). Lactobacilli were isolated using culture-based methods and identified to the species level. Antibiotic susceptibility testing was performed for all isolates. Biochemical and metabolic properties of antibiotic-sensitive strains were determined.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\n                      <jats:italic>Lactobacillus<\/jats:italic>\n                      species were identified. Six species were shared between groups, 12 were unique to centenarians, and two to young adults. Although overall Lactobacillaceae abundance was similar, centenarians showed greater species richness and a higher relative proportion of lactobacilli. Isolates from centenarians exhibited distinct carbohydrate fermentation patterns and metabolic profiles, including higher levels of acylcarnitines, arachidonic acid, and selected bile acids.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Lactobacilli isolated from centenarian demonstrate distinct compositional and metabolic characteristics compared with those from young adults. These differences may reflect functional adaptations potentially relevant to healthy ageing and could inform the selection of candidate strains for future probiotic development.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmicb.2026.1746411","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T06:41:25Z","timestamp":1773124885000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Culture-based studies of intestinal lactobacilli in young people and centenarians"],"prefix":"10.3389","volume":"17","author":[{"given":"Imbi","family":"Smidt","sequence":"first","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Institute of Biomedicine and Translational Medicine, University of Tartu","place":["Tartu, Estonia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiiu","family":"Roop","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Institute of Biomedicine and Translational Medicine, University of Tartu","place":["Tartu, Estonia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reet","family":"Mandar","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Institute of Biomedicine and Translational Medicine, University of Tartu","place":["Tartu, Estonia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jelena","family":"Stsepetova","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Institute of Biomedicine and Translational Medicine, University of Tartu","place":["Tartu, Estonia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siiri","family":"Koljalg","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Institute of Biomedicine and Translational Medicine, University of Tartu","place":["Tartu, Estonia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalle","family":"Kilk","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Institute of Biomedicine and Translational Medicine, University of Tartu","place":["Tartu, Estonia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Indrek","family":"Soidla","sequence":"additional","affiliation":[{"name":"Faculty of Social Sciences, Institute of Social Studies, University of Tartu","place":["Tartu, Estonia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mare","family":"Ainsaar","sequence":"additional","affiliation":[{"name":"Faculty of Social Sciences, Institute of Social Studies, University of Tartu","place":["Tartu, Estonia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helgi","family":"Kolk","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Institute of Clinical Medicine, University of Tartu","place":["Tartu, Estonia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Epp","family":"Sepp","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Institute of Biomedicine and Translational Medicine, University of Tartu","place":["Tartu, Estonia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"684730","DOI":"10.3389\/fmicb.2022.684730","article-title":"Co-occurrence of Lactobacillus species during fermentation of african indigenous foods: impact on food safety and shelf-life extension","volume":"13","author":"Adesulu-Dahunsi","year":"2022","journal-title":"Front. 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