{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:13:54Z","timestamp":1753892034284,"version":"3.41.2"},"reference-count":104,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T00:00:00Z","timestamp":1712793600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p><jats:bold>Introduction:<\/jats:bold> Asthma is a condition of airflow limitation, common throughout the world, with high mortality rates, especially as it still faces some obstacles in its management. As it constitutes a public health challenge, this study aimed to investigate the effect of copaiba oil (e.g., <jats:italic>Copaifera langsdorffii<\/jats:italic>), as a treatment resource, at doses of 50 and 100\u00a0mg\/kg on certain mediators of acute lung inflammation (IL-33, GATA3, FOXP3, STAT3, and TBET) and early mechanisms of lung remodeling (degradation of elastic fiber tissues, collagen deposition, and goblet cell hyperplasia).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Using an ovalbumin-induced acute allergic asthma model in BALB\/c mice, we analyzed the inflammatory mediators through immunohistochemistry and the mechanisms of lung remodeling through histopathology, employing orcein, Masson\u2019s trichrome, and periodic acid-Schiff staining.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Copaiba oil treatment (CO) reduced IL-33 and increased FOXP3 by stimulating the FOXP3\/GATA3 and FOXP3\/STAT3 pathways. Additionally, it upregulated TBET, suggesting an additional role in controlling GATA3 activity. In the respiratory epithelium, CO decreased the fragmentation of elastic fibers while increasing the deposition of collagen fibers, favoring epithelial restructuring. Simultaneously, CO reduced goblet cell hyperplasia.<\/jats:p><jats:p><jats:bold>Discussion:<\/jats:bold> Although additional research is warranted, the demonstrated anti-inflammatory and re-epithelializing action makes CO a viable option in exploring new treatments for acute allergic asthma.<\/jats:p>","DOI":"10.3389\/fphar.2024.1356598","type":"journal-article","created":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T05:04:36Z","timestamp":1712811876000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Copaiba oil minimizes inflammation and promotes parenchyma re-epithelization in acute allergic asthma model induced by ovalbumin in BALB\/c mice"],"prefix":"10.3389","volume":"15","author":[{"given":"Ludmila de Souza","family":"Caputo","sequence":"first","affiliation":[]},{"given":"Carolina de Lima","family":"Alves","sequence":"additional","affiliation":[]},{"given":"In\u00eas Martins","family":"Laranjeira","sequence":"additional","affiliation":[]},{"given":"Diana","family":"Fonseca-Rodrigues","sequence":"additional","affiliation":[]},{"given":"Ademar Alves","family":"da Silva Filho","sequence":"additional","affiliation":[]},{"given":"Alberto Carlos Pires","family":"Dias","sequence":"additional","affiliation":[]},{"given":"Filipa","family":"Pinto-Ribeiro","sequence":"additional","affiliation":[]},{"given":"Olavo dos Santos","family":"Pereira Junior","sequence":"additional","affiliation":[]},{"given":"Ana Claudia Chagas","family":"de Paula","sequence":"additional","affiliation":[]},{"given":"Akinori Cardozo","family":"Nagato","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9 Ot\u00e1vio do Amaral","family":"Corr\u00eaa","sequence":"additional","affiliation":[]}],"member":"1965","published-online":{"date-parts":[[2024,4,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1146\/annurev-pathol-042220-015902","article-title":"The pathology of asthma: what is obstructing our view?","volume":"18","author":"Aegerter","year":"2023","journal-title":"Annu. Rev. Pathol. Mech. Dis."},{"key":"B2","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.jaip.2019.11.008","article-title":"Allergic endotypes and phenotypes of asthma","volume":"8","author":"Akar-Ghibril","year":"2020","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"B3","doi-asserted-by":"publisher","first-page":"3568","DOI":"10.3390\/ijms21103568","article-title":"Safety and effectiveness of copaiba oleoresin (C. Reticulata ducke) on inflammation and tissue repair of oral wounds in rats","volume":"21","author":"Alvarenga","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"0187380","DOI":"10.1371\/journal.pone.0187380","article-title":"Wound healing properties of Copaifera paupera in diabetic mice","volume":"12","author":"Amorim","year":"2017","journal-title":"PLoS One"},{"key":"B5","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.lfs.2018.12.059","article-title":"The protective effects of \u03b2-caryophyllene on LPS-induced primary microglia M1\/M2 imbalance: a mechanistic evaluation","volume":"219","author":"Askari","year":"2019","journal-title":"Life Sci."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.22038\/IJBMS.2022.65622.14433","article-title":"Effects of crocin on T-bet\/GATA-3 ratio, and MiR-146a and MiR-106a expression levels in lung tissue of ovalbumin-sensitized mice","volume":"25","author":"Aslani","year":"2022","journal-title":"Iran. J. Basic Med. Sci."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1042\/CS20191309","article-title":"Bidirectional interaction of airway epithelial remodeling and inflammation in asthma","volume":"134","author":"Banno","year":"2020","journal-title":"Clin. Sci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1590\/0100-6991e-20192245","article-title":"An\u00e1lise Comparativa Dos Efeitos Do Mel, Do \u00d3leo-Serina de Copa\u00edba e de Um Produto Comercial (Fibrinolisina, Desoxirribonuclease e Cloranfenicol) Na Cicatriza\u00e7\u00e3o Por Segunda Inten\u00e7\u00e3o, Em Ratos","volume":"46","author":"Biondo-Sim\u00f5es","year":"2019","journal-title":"Rev. Col. Bras. Cir."},{"key":"B9","unstructured":"Em 2021, SUS Registrou 1,3 Milh\u00e3o de Atendimentos a Pacientes Com Asma Na Aten\u00e7\u00e3o Prim\u00e1ria \u00e0 Sa\u00fade2022"},{"key":"B10","doi-asserted-by":"publisher","first-page":"106177","DOI":"10.1016\/j.intimp.2019.106177","article-title":"Copaiba oil suppresses inflammation in asthmatic lungs of BALB\/c mice induced with ovalbumin","volume":"80","author":"Caputo","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.3390\/plants12051054","article-title":"Toxicological effects of copaiba oil (Copaifera spp.) and its active components","volume":"12","author":"Cardinelli","year":"2023","journal-title":"Plants"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cyto.2022.155891","article-title":"Cytokine interleukin-33 (IL-33): a critical review of its Biology and the mechanisms involved in its release as a potent extracellular cytokine","volume":"156","author":"Cayrol","year":"2022","journal-title":"Cytokine"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fimmu.2019.01267","article-title":"IL-10\/STAT3\/SOCS3 Axis is involved in the anti-inflammatory effect of benznidazole","volume":"10","author":"Cevey","year":"2019","journal-title":"Front. Immunol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"3096183","DOI":"10.1155\/2018\/3096183","article-title":"The imbalance of FOXP3\/GATA3 in regulatory T cells from the peripheral blood of asthmatic patients","volume":"2018","author":"Chen","year":"2018","journal-title":"J. Immunol. Res."},{"key":"B15","doi-asserted-by":"publisher","first-page":"862866","DOI":"10.3389\/fimmu.2022.862866","article-title":"The mechanisms of effector Th cell responses contribute to Treg cell function: new insights into pathogenesis and therapy of asthma","volume":"13","author":"Chen","year":"2022","journal-title":"Front. Immunol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.envpol.2019.06.096","article-title":"TAK1 knock-down in macrophage alleviate lung inflammation induced by black carbon and aged black carbon","volume":"253","author":"Cheng","year":"2019","journal-title":"Environ. Pollut."},{"key":"B17","doi-asserted-by":"publisher","first-page":"12814","DOI":"10.3390\/molecules190812814","article-title":"Copaiba oil suppresses inflammatory cytokines in splenocytes of C57Bl\/6 mice induced with experimental autoimmune encephalomyelitis (EAE)","volume":"19","author":"Dias","year":"2014","journal-title":"Molecules"},{"key":"B18","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.biopha.2017.04.092","article-title":"\u03b2-Caryophyllene ameliorates the development of experimental autoimmune encephalomyelitis in C57BL\/6 mice","volume":"91","author":"Fontes","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1215437","DOI":"10.3389\/fphar.2023.1215437","article-title":"Evaluation of the biological Activities of copaiba (Copaifera spp): a comprehensive review based on scientometric analysis","volume":"14","author":"Fraz\u00e3o","year":"2023","journal-title":"Front. Pharmacol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1002\/eji.201646450","article-title":"GATA-3-Specific DNAzyme \u2014 a novel approach for stratified asthma therapy","volume":"47","author":"Garn","year":"2017","journal-title":"Eur. J. Immunol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1111\/all.15609","article-title":"Sounding the alarmins\u2014the role of alarmin cytokines in asthma","volume":"78","author":"Gauvreau","year":"2023","journal-title":"Allergy"},{"key":"B22","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1097\/MCP.0000000000000615","article-title":"Anti-alarmin approaches entering clinical trials","volume":"26","author":"Gauvreau","year":"2020","journal-title":"Curr. Opin. Pulm. Med."},{"key":"B23","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.5588\/ijtld.22.1010","article-title":"The global asthma report","volume":"26","year":"2022","journal-title":"Int. J. Tuberc. Lung. Dis."},{"key":"B24","unstructured":"Global strategy for asthma management and prevention2022"},{"key":"B25","doi-asserted-by":"publisher","first-page":"475","DOI":"10.3389\/fimmu.2017.00475","article-title":"The ST2\/IL-33 Axis in immune cells during inflammatory diseases","volume":"8","author":"Griesenauer","year":"2017","journal-title":"Front. Immunol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.imlet.2018.11.012","article-title":"Mouse models of severe asthma for evaluation of therapeutic cytokine targeting","volume":"207","author":"Gubernatorova","year":"2019","journal-title":"Immunol. Lett."},{"key":"B27","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1016\/j.jaci.2007.03.047","article-title":"Rapid systemic uptake of allergens through the respiratory mucosa","volume":"120","author":"Hens","year":"2007","journal-title":"J. Allergy Clin. Immunol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"191","DOI":"10.3389\/fmed.2020.00191","article-title":"Airway remodeling in asthma","volume":"7","author":"Hough","year":"2020","journal-title":"Front. Med."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1080\/13880209.2022.2104327","article-title":"Louki zupa decoction attenuates the airway inflammation in acute asthma mice induced by ovalbumin through IL-33\/ST2-NF-\u03bab\/gsk3\u03b2\/MTOR signalling pathway","volume":"60","author":"Huang","year":"2022","journal-title":"Pharm. Biol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1165\/rcmb.2014-0290OC","article-title":"Role of matrix metalloproteinases-1 and-2 in interleukin-13-suppressed elastin in airway fibroblasts in asthma","volume":"54","author":"Ingram","year":"2016","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"342","DOI":"10.3390\/cells8040342","article-title":"Extracellular matrix component remodeling in respiratory diseases: what has been found in clinical and experimental studies?","volume":"8","author":"Ito","year":"2019","journal-title":"Cells"},{"key":"B32","doi-asserted-by":"publisher","first-page":"851374","DOI":"10.3389\/fphar.2022.851374","article-title":"Type IV collagen reduces MUC5AC secretion in the lungs of ovalbumin-sensitized mice","volume":"13","author":"Iwashita","year":"2022","journal-title":"Front. Pharmacol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1152\/japplphysiol.00554.2020","article-title":"Stiffening of the extracellular matrix is a sufficient condition for airway hyperreactivity","volume":"130","author":"Jamieson","year":"2021","journal-title":"J. Appl. Physiol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"114959","DOI":"10.1016\/j.biopha.2023.114959","article-title":"Bergapten ameliorates combined allergic rhinitis and asthma syndrome after PM2.5 exposure by balancing Treg\/Th17 expression and suppressing STAT3 and MAPK activation in a mouse model","volume":"164","author":"Jiang","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.1002\/wnan.1634","article-title":"T-cell targeted pulmonary SiRNA delivery for the treatment of asthma","volume":"12","author":"Keil","year":"2020","journal-title":"WIREs Nanomed. Nanobiotechnol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/S0041-008X(02)00025-X","article-title":"Airway fibrosis in a mouse model of airway inflammation","volume":"186","author":"Kenyon","year":"2003","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1016\/j.biopha.2018.04.164","article-title":"Trypanocidal activity of copaiba oil and kaurenoic acid does not depend on macrophage killing machinery","volume":"103","author":"Kian","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.mam.2021.100995","article-title":"Cellular and molecular mechanisms of allergic asthma","volume":"85","author":"Koml\u00f3si","year":"2022","journal-title":"Mol. Asp. Med."},{"key":"B39","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1007\/s12016-018-8712-1","article-title":"Understanding asthma phenotypes, endotypes, and mechanisms of disease","volume":"56","author":"Kuruvilla","year":"2019","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1918","DOI":"10.1111\/all.14257","article-title":"Stability of regulatory T cells in T helper 2 \u2013 biased allergic airway diseases","volume":"75","author":"Lan","year":"2020","journal-title":"Allergy"},{"key":"B41","doi-asserted-by":"publisher","first-page":"3866","DOI":"10.3390\/molecules17043866","article-title":"Chemistry and biological Activities of terpenoids from copaiba (Copaifera spp.) oleoresins","volume":"17","author":"Leandro","year":"2012","journal-title":"Molecules"},{"key":"B42","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.jep.2017.11.018","article-title":"Anti-allergic effects of sesquiterpene lactones from saussurea Costus (falc.) lipsch. Determined using in vivo and in vitro experiments","volume":"213","author":"Lee","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1007\/s10068-023-01278-1","article-title":"Low dose administration of mature silkworm powder induces gastric mucosal defense factors in ethanol - induced gastric injury rat model","volume":"32","author":"Lee","year":"2023","journal-title":"Food Sci. Biotechnol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"75","DOI":"10.17480\/psk.2017.61.2.75","article-title":"Pharmacological action of linalool, oleanolic acid and \u03b2-caryophyllene on gene expression and production of mucin from goblet cells in respiratory epithelium","volume":"61","author":"Lee","year":"2017","journal-title":"Yakhak Hoeji"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.3390\/plants12081619","article-title":"Chemical characterization and quality assessment of copaiba oil-resin using GC\/MS and SFC\/MS","volume":"12","author":"Lee","year":"2023","journal-title":"Plants"},{"key":"B46","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1186\/1465-9921-12-122","article-title":"Protease-activated receptor 2 activation of myeloid dendritic cells regulates allergic airway inflammation","volume":"12","author":"Lewkowich","year":"2011","journal-title":"Respir. Res."},{"key":"B47","doi-asserted-by":"publisher","first-page":"13","DOI":"10.18332\/tid\/156047","article-title":"How does cigarette smoking affect airway remodeling in asthmatics?","volume":"21","author":"Lin","year":"2023","journal-title":"Tob. Induc. Dis."},{"key":"B48","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3390\/bioengineering8010013","article-title":"Role of collagen in airway mechanics","volume":"8","author":"Liu","year":"2021","journal-title":"Bioengineering"},{"key":"B49","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1007\/s12016-021-08894-x","article-title":"Different phenotypes in asthma: clinical findings and experimental animal models","volume":"62","author":"Louren\u00e7o","year":"2022","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"641","DOI":"10.3892\/ijmm.2020.4622","article-title":"IL - 27 suppresses airway inflammation, hyperresponsiveness and remodeling via the STAT1 and STAT3 pathways in mice with allergic asthma","volume":"46","author":"Lu","year":"2020","journal-title":"Int. J. Mol. Cell. Med."},{"key":"B51","doi-asserted-by":"publisher","first-page":"19889","DOI":"10.1371\/journal.pone.0019889","article-title":"Expansion of CD4+ CD25+ and CD25- T-bet, GATA-3, Foxp3 and ROR\u03b3t cells in allergic inflammation, local lung distribution and chemokine gene expression","volume":"6","author":"Lu","year":"2011","journal-title":"PLoS One"},{"key":"B52","doi-asserted-by":"publisher","first-page":"974066","DOI":"10.3389\/fimmu.2022.974066","article-title":"Distinct spatial and temporal roles for Th1, Th2, and Th17 cells in asthma","volume":"13","author":"Luo","year":"2022","journal-title":"Front. Immunol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.chest.2017.11.008","article-title":"Mucins, mucus, and goblet cells","volume":"154","author":"Ma","year":"2017","journal-title":"Chest"},{"key":"B54","doi-asserted-by":"publisher","first-page":"100445","DOI":"10.1016\/j.cophys.2021.05.008","article-title":"Mechanical behavior of the airway wall in respiratory disease","volume":"22","author":"Maghsoudi-Ganjeh","year":"2021","journal-title":"Curr. Opin. Psychol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1111\/resp.13052","article-title":"Mouse models of severe asthma: understanding the mechanisms of steroid resistance, tissue remodelling and disease exacerbation","volume":"22","author":"Maltby","year":"2017","journal-title":"Respirology"},{"key":"B56","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1186\/s12931-023-02376-8","article-title":"Effects of tissue degradation by collagenase and elastase on the biaxial mechanics of porcine airways","volume":"24","author":"Mariano","year":"2023","journal-title":"Respir. Res."},{"key":"B57","doi-asserted-by":"publisher","first-page":"L763","DOI":"10.1152\/ajplung.00136.2017","article-title":"X-ray-based lung function measurement reveals persistent loss of lung tissue elasticity in mice recovered from allergic airway inflammation","volume":"313","author":"Markus","year":"2017","journal-title":"Am. J. Physiol. \u2013 Lung Cell. Mol. Physiol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1590\/0100-69912016006006","article-title":"Comparative analysis of the effects of Copaifera multijuga oil-resin and nitrofurazona in the cutaneous wound healing process","volume":"43","author":"Martini","year":"2016","journal-title":"Rev. Col. Bras. Cir."},{"key":"B59","first-page":"10","article-title":"Cytotoxicity and wound healing properties of Copaifera langsdorffii oleoresin in rabbits","volume":"3","author":"Masson-Meyers","year":"2013","journal-title":"Int. J. Nat. Product. Sci."},{"key":"B60","doi-asserted-by":"publisher","first-page":"2555","DOI":"10.1271\/bbb.80252","article-title":"Absorption, migration and kinetics in peripheral blood of orally administered ovalbumin in a mouse model","volume":"72","author":"Matsubara","year":"2008","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"B61","doi-asserted-by":"publisher","first-page":"08993","DOI":"10.1016\/j.heliyon.2022.e08993","article-title":"Anti-inflammatory and wound healing effect of copaiba oleoresin on the oral cavity: a systematic review","volume":"8","author":"Menezes","year":"2022","journal-title":"Heliyon"},{"key":"B62","doi-asserted-by":"publisher","first-page":"27","DOI":"10.7324\/JAPS.2019.90704","article-title":"\u03b2-Caryophyllene causes remyelination and modifies cytokines expression in C57bl\/6 mice with experimental autoimmune encephalomyelitis","volume":"9","author":"Mesquita","year":"2019","journal-title":"J. Appl. Pharm. Sci."},{"key":"B63","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1164\/rccm.201810-1855OC","article-title":"Defective fibrillar collagen organization by fibroblasts contributes to airway remodeling in asthma","volume":"200","author":"Mosta\u00e7o-Guidolin","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"B64","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1002\/iid3.71","article-title":"Hyperoxia promotes polarization of the immune response in ovalbumin-induced airway inflammation, leading to a TH17 cell phenotype","volume":"3","author":"Nagato","year":"2015","journal-title":"Immun. Inflamm. Dis."},{"key":"B65","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/s0091-6749(99)70493-8","article-title":"Gene expression of the GATA-3 transcription factor is increased in atopic asthma","volume":"103","author":"Nakamura","year":"1999","journal-title":"J. Allergy Clin. Immunol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1134\/S0006297921110122","article-title":"Role of STAT3 transcription factor in pathogenesis of bronchial asthma","volume":"86","author":"Nikolskii","year":"2021","journal-title":"Biochemistry"},{"key":"B67","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.ddmod.2019.04.001","article-title":"Extracellular matrix components remodeling and lung function parameters in experimental emphysema and allergic asthma: differences among the mouse strains","author":"Oliveira","year":"2019","journal-title":"Drug Discov. Today Dis. Models"},{"key":"B68","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-020-65567-z","article-title":"Epithelial-Interleukin-1 inhibits collagen formation by airway fibroblasts: implications for asthma","volume":"10","author":"Osei","year":"2020","journal-title":"Sci. Rep."},{"key":"B69","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/s0378-8741(98)00058-0","article-title":"Gastroprotective effect of Copaifera langsdorffii oleo-resin on experimental gastric ulcer models in rats","volume":"62","author":"Paiva","year":"1998","journal-title":"J. Ethnopharmacol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"289","DOI":"10.5935\/scd1984-8773.2017941102","article-title":"Effect of copaiba oil associated with microneedling on the skin of rats: a comparative study","volume":"9","author":"Palheta","year":"2017","journal-title":"Surg. Cosmet. Dermatol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"378","DOI":"10.3892\/mmr.2021.12017","article-title":"Fine particulate matter induces airway inflammation by disturbing the balance between Th1\/Th2 and regulation of GATA3 and Runx3 expression in BALB\/c mice","volume":"23","author":"Pang","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"B72","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.imlet.2019.12.003","article-title":"IL-33 changes CD25Hi Tregs to Th17 cells through a dendritic cell-mediated pathway","volume":"218","author":"Park","year":"2020","journal-title":"Immunol. Lett."},{"key":"B73","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.3390\/pathogens11121547","article-title":"The double game played by Th17 cells in infection: host defense and immunopathology","volume":"11","author":"Paroli","year":"2022","journal-title":"Pathogens"},{"key":"B74","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1111\/j.1365-2222.2005.2226.x","article-title":"Pharmacokinetics of radiolabelled par j 1 administered intranasally to allergic and healthy subjects","volume":"35","author":"Passalacqua","year":"2005","journal-title":"Clin. Exp. Allergy"},{"key":"B75","doi-asserted-by":"publisher","first-page":"153610","DOI":"10.1016\/j.phymed.2021.153610","article-title":"\u03b2-caryophyllene ameliorated obesity-associated airway hyperresponsiveness through some non-conventional targets","volume":"89","author":"Pathak","year":"2021","journal-title":"Phytomedicine"},{"key":"B76","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/S0140-6736(17)30879-6","article-title":"After asthma: redefining airways diseases","volume":"391","author":"Pavord","year":"2018","journal-title":"Lancet"},{"key":"B77","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.it.2016.03.007","article-title":"IL-33 in T Cell differentiation, function, and immune homeostasis","volume":"37","author":"Peine","year":"2016","journal-title":"Trends Immunol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1007\/s12079-018-0464-4","article-title":"A Network map of IL-33 signaling pathway","volume":"12","author":"Pinto","year":"2018","journal-title":"J. Cell Commun. Signal."},{"key":"B79","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1111\/j.1476-5381.2009.00177.x","article-title":"Preventive and therapeutic anti-inflammatory properties of the sesquiterpene alpha-humulene in experimental airways allergic inflammation","volume":"158","author":"Rogerio","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s40733-022-00084-6","article-title":"A serological biomarker of type I collagen degradation is related to a more severe, high neutrophilic, obese asthma subtype","volume":"8","author":"R\u00f8nnow","year":"2022","journal-title":"Asthma Res. Pract."},{"key":"B81","doi-asserted-by":"publisher","first-page":"1796","DOI":"10.1183\/13993003.01196-2014","article-title":"Novel concepts in airway inflammation and remodelling in asthma","volume":"46","author":"Saglani","year":"2015","journal-title":"Eur. Respir. J."},{"key":"B82","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/j.acthis.2016.07.001","article-title":"Sakuranetin reverses vascular peribronchial and lung parenchyma remodeling in a murine model of chronic allergic pulmonary inflammation","volume":"118","author":"Sakoda","year":"2016","journal-title":"Acta histochem."},{"key":"B83","doi-asserted-by":"publisher","first-page":"102262","DOI":"10.1016\/j.bcab.2021.102262","article-title":"Copaifera langsdorffii Desf.: a chemical and pharmacological review","volume":"39","author":"Santos","year":"2022","journal-title":"Biocatal. Agric. Biotechnol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.3390\/biomedicines10051017","article-title":"Asthma and post-asthmatic fibrosis: a search for new promising molecular markers of transition from acute inflammation to pulmonary fibrosis","volume":"10","author":"Savin","year":"2022","journal-title":"Biomedicines"},{"key":"B85","doi-asserted-by":"publisher","first-page":"L252","DOI":"10.1152\/ajplung.00019.2014","article-title":"Airway collagen and elastic fiber content correlates with lung function in equine heaves","volume":"307","author":"Setlakwe","year":"2014","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"207","DOI":"10.5935\/2526-5393.20190064","article-title":"Errata em: \u201cGuia pr\u00e1tico de atualiza\u00e7\u00e3o: medicamentos biol\u00f3gicos no tratamento da asma, doen\u00e7as al\u00e9rgicas e imunodefici\u00eancias\u201d","volume":"3","author":"Sol\u00e9","year":"2019","journal-title":"Braz. J. Allergy Immunol."},{"key":"B87","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1378\/chest.15-0947","article-title":"Airway goblet cells secrete pro-inflammatory cytokines, chemokines, and growth factors","volume":"149","author":"Tanabe","year":"2016","journal-title":"Chest"},{"key":"B88","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.niox.2021.08.006","article-title":"Nitric oxide nitric oxide in the marfan vasculature: friend or foe?","volume":"116","author":"Tehrani","year":"2021","journal-title":"Nitric Oxide"},{"key":"B89","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12906-017-1820-2","article-title":"Copaiba oil-resin (Copaifera reticulata ducke) modulates the inflammation in a model of injury to rats\u2019 tongues","volume":"17","author":"Teixeira","year":"2017","journal-title":"BMC Complement. Altern. Med."},{"key":"B90","doi-asserted-by":"publisher","first-page":"1128023","DOI":"10.3389\/fimmu.2023.1128023","article-title":"Understanding fibroblast-immune cell interactions via Co-culture models and their role in asthma pathogenesis","volume":"14","author":"Thiam","year":"2023","journal-title":"Front. Immunol."},{"key":"B91","doi-asserted-by":"publisher","first-page":"2383","DOI":"10.3390\/molecules24132383","article-title":"Differentiation of essential oils using nanofluidic protein post-translational modification profiling","volume":"24","author":"Urasaki","year":"2019","journal-title":"Molecules"},{"key":"B92","doi-asserted-by":"publisher","first-page":"108487","DOI":"10.1016\/j.intimp.2021.108487","article-title":"Sodium houttuynia alleviates airway inflammation in asthmatic mice by regulating FoxP3\/ror\u03b3t expression and reversing Treg\/Th17 cell imbalance","volume":"103","author":"Wang","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"B93","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.21037\/atm-21-2778","article-title":"Selective activation of cannabinoid receptor 2 regulates Treg\/Th17 balance to ameliorate neutrophilic asthma in mice","volume":"9","author":"Wei","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"B94","unstructured":"Asthma2023"},{"key":"B95","doi-asserted-by":"publisher","first-page":"717962","DOI":"10.3389\/fmolb.2021.717962","article-title":"STAT3 and IL-6 contribute to corticosteroid resistance in an OVA and ozone-induced asthma model with neutrophil infiltration","volume":"8","author":"Xue","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"B96","doi-asserted-by":"publisher","first-page":"10967","DOI":"10.1074\/jbc.M109986200","article-title":"Transcriptional stimulation of the surfactant protein B gene by STAT3 in respiratory epithelial cells","volume":"277","author":"Yan","year":"2002","journal-title":"J. Biol. Chem."},{"key":"B97","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3892\/etm.2018.6939","article-title":"Oligo-fucoidan improved unbalance the Th1\/Th2 and Treg\/Th17 ratios in asthmatic patients: an ex vivo study","volume":"17","author":"Yang","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"B98","doi-asserted-by":"publisher","first-page":"761","DOI":"10.3390\/antiox10050761","article-title":"Humulene inhibits acute gastric mucosal injury by enhancing mucosal integrity","volume":"10","author":"Yeo","year":"2021","journal-title":"Antioxidants"},{"key":"B99","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.matbio.2023.10.003","article-title":"Pulmonary fibroelastosis - a review","volume":"124","author":"Yombo","year":"2023","journal-title":"Matrix Biol."},{"key":"B100","doi-asserted-by":"publisher","first-page":"451","DOI":"10.3109\/02770903.2014.887727","article-title":"Enhanced local Foxp3 expression in lung tissue attenuates airway inflammation in a mouse model of asthma","volume":"51","author":"Zhang","year":"2014","journal-title":"J. Asthma"},{"key":"B101","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1080\/01902148.2019.1611972","article-title":"IL33\/ST2 contributes to airway remodeling via p-JNK MAPK\/STAT3 signaling pathway in OVA-induced allergic airway inflammation in mice","volume":"45","author":"Zhang","year":"2019","journal-title":"Exp. Lung Res."},{"key":"B102","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1093\/jpp\/rgab074","article-title":"\u03b2-Caryophyllene attenuates lipopolysaccharide-induced acute lung injury via inhibition of the MAPK signalling pathway","volume":"73","author":"Zhang","year":"2021","journal-title":"J. Pharm. Pharmacol."},{"key":"B103","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.matbio.2018.03.005","article-title":"Extracellular matrix in lung development, homeostasis and disease","volume":"73","author":"Zhou","year":"2019","journal-title":"Matrix Biol."},{"key":"B104","doi-asserted-by":"publisher","first-page":"7835284","DOI":"10.1155\/2020\/7835284","article-title":"The role of T cells and macrophages in asthma pathogenesis: a new perspective on mutual crosstalk","volume":"2020","author":"Zhu","year":"2020","journal-title":"Mediat. Inflamm."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2024.1356598\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T05:04:42Z","timestamp":1712811882000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2024.1356598\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,11]]},"references-count":104,"alternative-id":["10.3389\/fphar.2024.1356598"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2024.1356598","relation":{},"ISSN":["1663-9812"],"issn-type":[{"type":"electronic","value":"1663-9812"}],"subject":[],"published":{"date-parts":[[2024,4,11]]},"article-number":"1356598"}}