{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T11:37:42Z","timestamp":1774611462050,"version":"3.50.1"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T00:00:00Z","timestamp":1729468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Transfusion Transmitted Infections (TTIs) are still a growing public health problem in Africa. Studies that synthesize the available evidence on the seroprevalence of Hepatitis B Surface Antigen (HBsAg) among African blood donors are scarce. Therefore, this study aimed to synthesize qualitatively and quantitatively the seroprevalence of Hepatitis B Virus Surface Antigen (HBsAg) among blood donors in Africa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a systematic review and meta-analysis where we included all studies that reported the seroprevalence of HBsAg among blood donors in Africa. The references were searched from electronic databases: PubMed, Web of Science, Cochrane, Scopus, WHO research database-HINARI, Global Index Medicus and <jats:ext-link>ClinicalTrials.gov<\/jats:ext-link>. We further analyzed the full list of references of all included studies. The pooled seroprevalence was estimated through random effect model. The heterogeneity was assessed through Cochrane\u2019s <jats:italic>Q<\/jats:italic> test and <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>, respectively. Meta-regression, subgroup and sensitivity analyses were conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We obtained 124 studies that met our inclusion criteria, comprising 3,573,211 blood donors tested for HBsAg. The pooled seroprevalence of HBsAg among blood donors in Africa was 6.93% (95% CI: 5.95\u20137.97%; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> =\u2009100%; <jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001). We found that the heterogeneity was explained by the study performed country and, African region. The higher prevalence was observed in Western 10.09% (95% CI: 8.75\u201311.50%), Central 7.81% (95% CI: 5.34\u201310.71%), and Eastern African region 4.87% (95% CI: 3.77\u20136.11%) and lower prevalence were observed in Southern 2.47% (95% CI: 0.54\u20135.75%) followed by Northern Africa region with 1.73% (95% CI: 0.45\u20133.79%). Additionally, based on the date of publication, we found that the highest prevalence was observed in studies published between 2001 and 2010 (9.41, 95% CI: 7.19\u201311.90) and the lowest prevalence was observed in studies published between 2011 and 2024 (6.26%; 95% CI: 5.19\u20137.42).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The seroprevalence of HBsAg among blood donors in Africa is still very high and heterogeneous. Therefore, intensifying the screening and vaccination of the population for Hepatitis B is critical to ensure blood safety toward eliminating Hepatitis B in Africa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Systematic review registration<\/jats:title><jats:p><jats:uri>https:\/\/www.crd.york.ac.uk\/prospero\/display_record.php?RecordID=395616<\/jats:uri>, PROSPERO CRD42023395616.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpubh.2024.1434816","type":"journal-article","created":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T04:40:38Z","timestamp":1729485638000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Seroprevalence of Hepatitis B virus surface antigen among African blood donors: a systematic review and meta-analysis"],"prefix":"10.3389","volume":"12","author":[{"given":"Angelina Edna","family":"Quintas","sequence":"first","affiliation":[]},{"given":"Nelson","family":"Cuboia","sequence":"additional","affiliation":[]},{"given":"Lemuel","family":"Cordeiro","sequence":"additional","affiliation":[]},{"given":"Ant\u00f3nio","family":"Sarmento","sequence":"additional","affiliation":[]},{"given":"Lu\u00eds","family":"Azevedo","sequence":"additional","affiliation":[]}],"member":"1965","published-online":{"date-parts":[[2024,10,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.14309\/ajg.0000000000000651","article-title":"Prevalence of chronic hepatitis B virus infection in the United States","volume":"115","author":"Lim","year":"2020","journal-title":"Am J Gastroenterol"},{"key":"ref2","volume-title":"Hepatitis B","year":"2022"},{"key":"ref3","volume-title":"Screening and testing recommendations for chronic hepatitis B virus infection 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