{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T05:11:45Z","timestamp":1782623505843,"version":"3.54.5"},"reference-count":27,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2005,8,31]],"date-time":"2005-08-31T00:00:00Z","timestamp":1125446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Syntheses of steroidal heterocycles containing a five-membered N,S- heterocycle attached at the 6,7 positions of the B ring are reported. 5\u03b1-Cholestane-6-one (1), its 3\u03b2-acetoxy- (2) and 3\u03b2-chloro- (3) analogues reacted with semicarbazide and aqueous sodium acetate in refluxing ethanol to yield 5\u03b1-cholestan-6-one-semicarbazone 1a and its 3-\u03b2-acetoxy and 3\u03b2-chloro derivatives 2a and 3a, respectively. The reactions of 1a, 2a and 3a with thionyl chloride in dichloromethane at low temperature afforded the cyclized thiadiazole 4 and its 3\u03b2-acetoxy- and 3\u03b2-chloro analogues 5 and 6 in good yields.<\/jats:p>","DOI":"10.3390\/10070803","type":"journal-article","created":{"date-parts":[[2008,10,25]],"date-time":"2008-10-25T13:32:11Z","timestamp":1224941531000},"page":"803-808","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Synthesis of Steroidal Thiadiazoles from Steroidal Ketones"],"prefix":"10.3390","volume":"10","author":[{"given":"M.","family":"Mushfiq","sequence":"first","affiliation":[{"name":"Department of Chemistry, A.M.U., India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Alam","sequence":"additional","affiliation":[{"name":"Department of Chemistry, A.M.U., India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Akhtar","sequence":"additional","affiliation":[{"name":"Department of Chemistry, A.M.U., India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2005,8,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Lalezari, I., Shafiee, A., and Yazdani, S. 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