{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:41:41Z","timestamp":1760244101923,"version":"build-2065373602"},"reference-count":25,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2005,8,31]],"date-time":"2005-08-31T00:00:00Z","timestamp":1125446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The synthesis of 3-alkyl(aryl)-4-(3-ethoxy-4-hydroxybenzylidenamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones 3 from the reactions of 3-alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones 2 with 3-ethoxy-4-hydroxybenzaldehyde is described.The acetylation and methylation reactions of the compounds 3 giving compounds of type4 and 5, respectively, were investigated. The newly synthesized compounds werecharacterized using elemental analyses and IR, 1H-NMR, 13C-NMR and UV spectral data.In addition, to investigate the effects of solvents and molecular structure upon acidity,compounds 3 were titrated potentiometrically with tetrabutylammonium hydroxide infour non-aqueous solvents (isopropyl alcohol, tert-butyl alcohol, acetonitrile and N,N-dimethylformamide). The half-neutralization potential values and the corresponding pKavalues were determined for all cases.<\/jats:p>","DOI":"10.3390\/10080961","type":"journal-article","created":{"date-parts":[[2008,10,25]],"date-time":"2008-10-25T13:32:11Z","timestamp":1224941531000},"page":"961-970","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Synthesis and Non-Aqueous Medium Titrations of Some New 4-Benzylidenamino-4,5-dihydro-1H-1,2,4-triazol-5-one Derivatives"],"prefix":"10.3390","volume":"10","author":[{"given":"Haydar","family":"Y\u00fcksek","sequence":"first","affiliation":[{"name":"Education Faculty, Kafkas University, 36100 Kars, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osman","family":"\u00dcc\u00fcnc\u00fc","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Kafkas University, 36100 Kars, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muzaffer","family":"Alkan","sequence":"additional","affiliation":[{"name":"Education Faculty, Kafkas University, 36100 Kars, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zafer","family":"Ocak","sequence":"additional","affiliation":[{"name":"Education Faculty, Kafkas University, 36100 Kars, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sule","family":"Bahceci","sequence":"additional","affiliation":[{"name":"Fatih Education Faculty, Karadeniz Technical University, 61080 Trabzon, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2005,8,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1211\/0022357011775307","article-title":"Synthesis and in-vitro antimicrobial activity of new 1,2,4-triazoles","volume":"53","author":"Bhat","year":"2001","journal-title":"J. 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