{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:15:31Z","timestamp":1761488131258,"version":"build-2065373602"},"reference-count":17,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2006,4,10]],"date-time":"2006-04-10T00:00:00Z","timestamp":1144627200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>A simple, efficient, and general method has been developed for the synthesis of various N-aryl heterocylic substituted-4-aminoquinazoline compounds from 4-chloro- quinazoline and aryl heterocyclic amines under microwave irradiation using 2-propanol as solvent. The advantages of the use of microwave irradiation in relation to the classical method were demonstrated.<\/jats:p>","DOI":"10.3390\/11040272","type":"journal-article","created":{"date-parts":[[2008,10,25]],"date-time":"2008-10-25T13:32:11Z","timestamp":1224941531000},"page":"272-278","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Microwave Assisted Synthesis of N-Arylheterocyclic Substituted-4-aminoquinazoline Derivatives"],"prefix":"10.3390","volume":"11","author":[{"given":"Gang","family":"Liu","sequence":"first","affiliation":[{"name":"Center for Research and Development of Fine Chemicals, Guizhou University, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guiyang, 550025, P. R. 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Chem."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1021\/jm980572i","article-title":"Synthesis and antiparasitic and antitumor activity of 2, 4-diamino-6-(arylmethyl)-5,6,7,8-tetrahydroquinazoline analogues of piritrexim","volume":"42","author":"Rosowsky","year":"1999","journal-title":"J. Med. Chem."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/978-1-4615-2584-4_40","article-title":"The antitumour activity of ZD9331, a non-polyglutamatable quinazoline thymidylate synthase inhibitor","volume":"370","author":"Jackman","year":"1994","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3660","DOI":"10.1021\/jm00018a027","article-title":"Nonclassical 2,4-diamino-6-(aminomethyl) -5,6,7,8-tetrahydroquinazoline antifolates: synthesis and biological activities","volume":"38","author":"Gangjee","year":"1995","journal-title":"J. Med. Chem."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"5247","DOI":"10.1021\/jm980273t","article-title":"Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP)","volume":"41","author":"Griffin","year":"1998","journal-title":"J. Med. Chem."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1021\/jm990482t","article-title":"Tyrosine kinase inhibitors. 17. Irreversible inhibitors of the epidermal growth factor receptor: 4-(phenylamino)quinazoline- and 4-(phenylamino)pyrido[3,2-d]pyrimidine-6-acrylamides bearing additional solubilizing functions","volume":"43","author":"Smaill","year":"2000","journal-title":"J. Med. Chem."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"3244","DOI":"10.1021\/jm000206a","article-title":"4-Anilino-6,7-dialkoxyquinoline-3-carbonitrile inhibitors of epidermal growth factor receptor kinase and their bioisosteric relationship to the 4-anilino-6,7- dialkoxyquinazoline inhibitors","volume":"43","author":"Wissner","year":"2000","journal-title":"J. Med. Chem."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1021\/jm9503613","article-title":"Tyrosine kinase inhibitors .8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor","volume":"39","author":"Bridges","year":"1996","journal-title":"J. Med. Chem."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/S0006-2952(98)00356-6","article-title":"Irreversible inhibition of epidermal growth factor receptor tyrosine kinase with in vivo activity by N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]- 2-butynamide (CL-387,785)","volume":"57","author":"Discafani","year":"1999","journal-title":"Biochem. Pharmacol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1021\/jm950692f","article-title":"Tyrosine kinase inhibitors. 9. Synthesis and evaluation of fused tricyclic quinazoline analogues as ATP site inhibitors of the tyrosine kinase activity of the epidermal growth factor receptor","volume":"39","author":"Rewcastle","year":"1996","journal-title":"J. Med. Chem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/1521-4184(200112)334:11<357::AID-ARDP357>3.0.CO;2-Q","article-title":"1,4-dioxane-fused 4-anilinoquinazoline as inhibitors of epidermal growth factor receptor kinase","volume":"334","author":"Lee","year":"2001","journal-title":"Archiv der Pharmazie."},{"key":"ref_13","unstructured":"Lee, Y. S., Park, H. K., Lee, J. Y., Yang, B. S., and Suh, S. H. (2003). Preparation of 4-phenylamino-[1,4] dioxano[2,3-g]quinazolines as tyrosine kinase inhibitors. (2003026682), JP Patent, Chem. Abstr. 2003, 138, 122652c."},{"key":"ref_14","unstructured":"Jersak, U., and Scheuermann, H. (1978). Halogenated benzoic acid compounds. (2721133), DE Patent, Chem. Abstr. 1978, 91, 056647n."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1021\/ja01211a055","article-title":"Quinazoline derivatives. I. The synthesis of 4-(4\u2019-diethylamino-1\u2019-methylbutylamino)quinazoline (SN 11,534) and the corresponding 2-phenylquinazoline (SN 11,535)","volume":"68","author":"Endicott","year":"1946","journal-title":"J. Am. Chem. Soc."},{"key":"ref_16","first-page":"787","article-title":"Search for new antimalarials. III. Synthesis of some substituted quinazolines","volume":"36","author":"Sen","year":"1959","journal-title":"J. Indian Chem. Soc."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Armarego, W. L. F. (1962). Quinazolines. IV. Covalent hydration in the cations of sustituted quinazolines. J. Chem. 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