{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T22:40:22Z","timestamp":1773182422077,"version":"3.50.1"},"reference-count":30,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2006,11,17]],"date-time":"2006-11-17T00:00:00Z","timestamp":1163721600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>2\u2013Amino\u20134-phenyl\u20135,6,7,8\u2013tetrahydroquinoline\u20133\u2013carbonitrile (3) was synthesized by treating cyclohexanone (1) with 2\u2013benzylidenemalononitrile (2) in the presence of ammonium acetate. The reactivity of compound 3 towards dimethylformamide dimethyl acetal (DMF-DMA), carbon disulfide, urea, thiourea, formamide, formic acid, acetyl chloride and isothiocyanate were studied. In addition, the antimicrobial activity of some selected derivatives is reported.<\/jats:p>","DOI":"10.3390\/11110890","type":"journal-article","created":{"date-parts":[[2008,10,25]],"date-time":"2008-10-25T13:32:11Z","timestamp":1224941531000},"page":"890-903","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Facile Synthesis of 5, 6, 7, 8-Tetrahydropyrimido [4, 5-b]-quinoline Derivatives"],"prefix":"10.3390","volume":"11","author":[{"given":"Yehya Mahmud","family":"Elkholy","sequence":"first","affiliation":[{"name":"Chemistry Department, Faculty of Science, Helwan University, Helwan, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Abdelhamed","family":"Morsy","sequence":"additional","affiliation":[{"name":"Chemistry Department, Faculty of Science, Helwan University, Helwan, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2006,11,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2174\/187152106774755626","article-title":"Recent developments in antimalarials drug discovery","volume":"5","author":"Joshi","year":"2006","journal-title":"Anti-Infect. 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