{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:25:35Z","timestamp":1790367935114,"version":"4.1.0"},"reference-count":36,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2007,8,20]],"date-time":"2007-08-20T00:00:00Z","timestamp":1187568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Chemical evaluation of the semi-purified fraction from the seeds of guaran\u00e1, Paullinia cupana H.B.K. var. sorbilis (Mart.) Ducke, yielded the following compounds: caffeine, catechin, epicatechin, ent-epicatechin, and procyanidins B1, B2, B3, B4, A2, and C1. Measurement of the antioxidant activity by reduction of the DPPH radical confirmed the anti-radical properties of the aqueous (AqE) and crude (EBPC) extracts and semi-purified (EPA and EPB) fractions. The EPA fraction showed radical-scavenging activity (RSA) and protected DPPH from discoloration at 5.23\u00b10.08 (RSD%=1.49) \u03bcg\/mL, and for the phosphomolybdenum complex showed a higher Relative Antioxidant Capacity (RAC) at 0.75\u00b10.01 (1.75). The EPA fraction had a total polyphenolics content of 65.80%\u00b10.62 (RSD%=0.93). The plant drug showed 5.47% \u00b1 0.19 (RSD%=3.51) and 6.19% \u00b1 0.08 (RSD%=1.29) for total polyphenolics and methylxanthines, respectively. In vitro assessment of the antibacterial potential of the Paullinia cupana extracts against Streptococcus mutans showed that these could be used in the prevention of bacterial dental plaque.<\/jats:p>","DOI":"10.3390\/12081950","type":"journal-article","created":{"date-parts":[[2008,10,25]],"date-time":"2008-10-25T13:32:11Z","timestamp":1224941531000},"page":"1950-1963","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Antioxidant Capacity and In Vitro Prevention of Dental Plaque Formation by Extracts and Condensed Tannins of Paullinia cupana"],"prefix":"10.3390","volume":"12","author":[{"given":"Elza","family":"Yamaguti-Sasaki","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, Universidade Estadual de Maring\u00e1, Av. Colombo, 5790, BR-87020-900, Maring\u00e1, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lia Akina","family":"Ito","sequence":"additional","affiliation":[{"name":"Departamento de Farm\u00e1cia e Farmacologia, Universidade Estadual de Maring\u00e1, Av. Colombo, 5790, BR-87020-900, Maring\u00e1, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa Cristina Dias","family":"Canteli","sequence":"additional","affiliation":[{"name":"Departamento de Farm\u00e1cia e Farmacologia, Universidade Estadual de Maring\u00e1, Av. Colombo, 5790, BR-87020-900, Maring\u00e1, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00e2nia Mara Antonelli","family":"Ushirobira","sequence":"additional","affiliation":[{"name":"CCAS, Pontif\u00edcia Universidade Cat\u00f3lica, Av. Tiradentes, 963, BR-87013-260, Maring\u00e1, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00e2nia","family":"Ueda-Nakamura","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, Universidade Estadual de Maring\u00e1, Av. Colombo, 5790, BR-87020-900, Maring\u00e1, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedito Prado Dias","family":"Filho","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, Universidade Estadual de Maring\u00e1, Av. Colombo, 5790, BR-87020-900, Maring\u00e1, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celso Vataru","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, Universidade Estadual de Maring\u00e1, Av. Colombo, 5790, BR-87020-900, Maring\u00e1, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Carlos","family":"Palazzo de Mello","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, Universidade Estadual de Maring\u00e1, Av. Colombo, 5790, BR-87020-900, Maring\u00e1, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2007,8,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1590\/S1516-89132005000600007","article-title":"Effect of Crude Extract and its Semi Purified Constituents from Guaran\u00e1 Seeds [Paullinia cupana var. sorbilis (Mart.) Ducke on Cognitive Performance in Morris Water Maze in Rats","volume":"48","author":"Otobone","year":"2005","journal-title":"Braz. Arch. Biol. 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