{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:42:10Z","timestamp":1760244130322,"version":"build-2065373602"},"reference-count":25,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2004,11,30]],"date-time":"2004-11-30T00:00:00Z","timestamp":1101772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The alkylation of \u03b2-dicarbonyl compounds in a K2CO3\/DMSO system wasfound to afford O- and C-alkylated derivatives, depending on the type of the \u03b2-dicarbonylcompound involved. The alkyl derivatives obtained were used in the synthesis of some newspiro barbituric acid derivatives. Quantum chemical calculations were carried out toelucidate the reaction mechanisms for some typical synthesis.<\/jats:p>","DOI":"10.3390\/91100922","type":"journal-article","created":{"date-parts":[[2008,10,25]],"date-time":"2008-10-25T13:32:11Z","timestamp":1224941531000},"page":"922-938","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Quantum Chemical and Experimental Studies on the Mechanism of Alkylation of \u03b2-Dicarbonyl Compounds. The Synthesis of Five and Six Membered Heterocyclic Spiro Derivatives"],"prefix":"10.3390","volume":"9","author":[{"given":"Nurettin","family":"Sadikov","sequence":"first","affiliation":[{"name":"Baku St. University, Faculty of Chemistry, Department of Organic Chemistry, Baku, Azerbaijan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahin","family":"Nasibov","sequence":"additional","affiliation":[{"name":"Baku St. University, Faculty of Chemistry, Department of Organic Chemistry, Baku, Azerbaijan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cemil","family":"Ogretir","sequence":"additional","affiliation":[{"name":"Osmangazi University, Faculty of Arts and Sciences, Chemistry Department, 26040 Eski\u015fehir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Halil","family":"Berber","sequence":"additional","affiliation":[{"name":"Anadolu University, Faculty of Sciences, Chemistry Department, 26470 Eski\u015fehir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"H\u00fcseyinli","sequence":"additional","affiliation":[{"name":"Baku St. University, Faculty of Chemistry, Department of Analytical Chemistry, Baku, Azerbaijan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2004,11,30]]},"reference":[{"key":"ref_1","first-page":"474","article-title":"Cycloalcylation by the \u03b1,\u03c9-Dibromides of Compounds Containing an Activated Methylene Group as a Method for the Synthesis of 1,1-Disubstitutedcycloalkanes","volume":"19","author":"Zefirov","year":"1983","journal-title":"J. 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USSR"},{"key":"ref_6","first-page":"288","article-title":"Crystal and Molecular Structure of 1,1-Dichlorotetraspiro[2.0.0.2.0.2.0.1]-Undecane","volume":"320","author":"Yufit","year":"1991","journal-title":"Dokl. Chem. (Engl. Transl.)"},{"key":"ref_7","first-page":"422","article-title":"Reaction of Allenes with 1,1-Dichloroethane and Butyllithium","volume":"27","author":"Lukin","year":"1991","journal-title":"J. Org. Chem. USSR"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1002\/anie.199408691","article-title":"Hexaspiro[2.4.2.4.2.4.2.4.2.4.2.4]Dotetraconta-4,6,11,13,18,20,25,27,32,34,39,41-Dodecain - ein Explodierendes [6]Rotan","volume":"33","author":"Kozhushkov","year":"1994","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"ref_9","unstructured":"de Meijere, A., Becker, H., Kozhushkov, S. I., and Noltemeyer, M. (2004). 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