{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T12:13:19Z","timestamp":1768565599856,"version":"3.49.0"},"reference-count":64,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,4,9]],"date-time":"2021-04-09T00:00:00Z","timestamp":1617926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2017J01607, 2018J01612"],"award-info":[{"award-number":["2017J01607, 2018J01612"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Forestry Science and Technology Projects in Fujian Province","award":["Memorandums 26"],"award-info":[{"award-number":["Memorandums 26"]}]},{"name":"Special Funds of Science and Technology Innovation Project of Fujian Agriculture and Forestry University","award":["KFA17030A, KFA17181A"],"award-info":[{"award-number":["KFA17030A, KFA17181A"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Algorithms"],"abstract":"<jats:p>Quantitative Structure\u2013Activity Relationship (QSAR) aims to correlate molecular structure properties with corresponding bioactivity. Chance correlations and multicollinearity are two major problems often encountered when generating QSAR models. Feature selection can significantly improve the accuracy and interpretability of QSAR by removing redundant or irrelevant molecular descriptors. An artificial bee colony algorithm (ABC) that mimics the foraging behaviors of honey bee colony was originally proposed for continuous optimization problems. It has been applied to feature selection for classification but seldom for regression analysis and prediction. In this paper, a binary ABC algorithm is used to select features (molecular descriptors) in QSAR. Furthermore, we propose an improved ABC-based algorithm for feature selection in QSAR, namely ABC-PLS-1. Crossover and mutation operators are introduced to employed bee and onlooker bee phase to modify several dimensions of each solution, which not only saves the process of converting continuous values into discrete values, but also reduces the computational resources. In addition, a novel greedy selection strategy which selects the feature subsets with higher accuracy and fewer features helps the algorithm to converge fast. Three QSAR datasets are used for the evaluation of the proposed algorithm. Experimental results show that ABC-PLS-1 outperforms PSO-PLS, WS-PSO-PLS, and BFDE-PLS in accuracy, root mean square error, and the number of selected features. Moreover, we also study whether to implement scout bee phase when tracking regression problems and drawing such an interesting conclusion that the scout bee phase is redundant when dealing with the feature selection in low-dimensional and medium-dimensional regression problems.<\/jats:p>","DOI":"10.3390\/a14040120","type":"journal-article","created":{"date-parts":[[2021,4,9]],"date-time":"2021-04-09T10:05:21Z","timestamp":1617962721000},"page":"120","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["An Improved Artificial Bee Colony for Feature Selection in QSAR"],"prefix":"10.3390","volume":"14","author":[{"given":"Yanhong","family":"Lin","sequence":"first","affiliation":[{"name":"College of Computer and Information Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8360-5395","authenticated-orcid":false,"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Computer and Information Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China"}]},{"given":"Xiaolin","family":"Li","sequence":"additional","affiliation":[{"name":"College of Computer and Information Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China"}]},{"given":"Yuanzi","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Computer and Information Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China"}]},{"given":"Shiguo","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Computer and Information Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Toropov, A.A., and Toropova, A.P. 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