{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T03:04:11Z","timestamp":1784343851504,"version":"3.55.0"},"reference-count":28,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:00:00Z","timestamp":1713744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cEvaluation of incidence, prevalence, risk factors, research of clinical, neuroimaging, neurophysiological, and neurotrophic remedial aspects of cerebrovascular accidents in children\u201d within the state program \u201cSystemogenesis of risk factors, optimization of the medical assistance service, evaluation sustainable and mathematical modeling of Stroke\u201d","award":["17.000418.80.07A"],"award-info":[{"award-number":["17.000418.80.07A"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Algorithms"],"abstract":"<jats:p>Childhood stroke can lead to lifelong disability. Developing algorithms for timely recognition of clinical and paraclinical signs is crucial to ensure prompt stroke diagnosis and minimize decision-making time. This study aimed to characterize clinical and paraclinical symptoms of childhood and neonatal stroke as relevant diagnostic criteria encountered in clinical practice, in order to develop algorithms for prompt stroke diagnosis. The analysis included data from 402 pediatric case histories from 2010 to 2016 and 108 prospective stroke cases from 2017 to 2020. Stroke cases were predominantly diagnosed in newborns, with 362 (71%, 95% CI 68.99\u201373.01) cases occurring within the first 28 days of birth, and 148 (29%, 95% CI 26.99\u201331.01) cases occurring after 28 days. The findings of the study enable the development of algorithms for timely stroke recognition, facilitating the selection of optimal treatment options for newborns and children of various age groups. Logistic regression serves as the basis for deriving these algorithms, aiming to initiate early treatment and reduce lifelong morbidity and mortality in children. The study outcomes include the formulation of algorithms for timely recognition of newborn stroke, with plans to adopt these algorithms and train a fuzzy classifier-based diagnostic model using machine learning techniques for efficient stroke recognition.<\/jats:p>","DOI":"10.3390\/a17040171","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T07:44:09Z","timestamp":1713771849000},"page":"171","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Pediatric Ischemic Stroke: Clinical and Paraclinical Manifestations\u2014Algorithms for Diagnosis and Treatment"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0922-9971","authenticated-orcid":false,"given":"Niels","family":"Wessel","sequence":"first","affiliation":[{"name":"Department of Human Medicine, MSB Medical School Berlin GmbH, 12247 Berlin, Germany"},{"name":"Department of Physics, Humboldt-Universit\u00e4t zu Berlin, 12489 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Sprincean","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Human Genetics, \u201cNicolae Testemitanu\u201d State University of Medicine and Pharmacy, 2004 Chisinau, Moldova"},{"name":"Public Health Medical Institution Mother and Child Institute, MD 2062 Chisinau, Moldova"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0382-4542","authenticated-orcid":false,"given":"Ludmila","family":"Sidorenko","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Human Genetics, \u201cNicolae Testemitanu\u201d State University of Medicine and Pharmacy, 2004 Chisinau, Moldova"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5229-7841","authenticated-orcid":false,"given":"Ninel","family":"Revenco","sequence":"additional","affiliation":[{"name":"Public Health Medical Institution Mother and Child Institute, MD 2062 Chisinau, Moldova"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Hadjiu","sequence":"additional","affiliation":[{"name":"Public Health Medical Institution Mother and Child Institute, MD 2062 Chisinau, Moldova"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Guiraut, C., Cauchon, N., Lepage, M., and S\u00e9bire, G. 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