{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T22:41:27Z","timestamp":1760222487264,"version":"build-2065373602"},"reference-count":92,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2009,6,4]],"date-time":"2009-06-04T00:00:00Z","timestamp":1244073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Algorithms"],"abstract":"<jats:p>As the rapid advance of digital imaging technologies, the content-based image retrieval (CBIR) has became one of the most vivid research areas in computer vision. In the last several years, developing computer-aided detection and\/or diagnosis (CAD) schemes that use CBIR to search for the clinically relevant and visually similar medical images (or regions) depicting suspicious lesions has also been attracting research interest. CBIR-based CAD schemes have potential to provide radiologists with \u201cvisual aid\u201d and increase their confidence in accepting CAD-cued results in the decision making. The CAD performance and reliability depends on a number of factors including the optimization of lesion segmentation, feature selection, reference database size, computational efficiency, and relationship between the clinical relevance and visual similarity of the CAD results. By presenting and comparing a number of approaches commonly used in previous studies, this article identifies and discusses the optimal approaches in developing CBIR-based CAD schemes and assessing their performance. Although preliminary studies have suggested that using CBIR-based CAD schemes might improve radiologists\u2019 performance and\/or increase their confidence in the decision making, this technology is still in the early development stage. Much research work is needed before the CBIR-based CAD schemes can be accepted in the clinical practice.<\/jats:p>","DOI":"10.3390\/a2020828","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T04:00:31Z","timestamp":1244174431000},"page":"828-849","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Computer-Aided Diagnosis in Mammography Using Content-Based Image Retrieval Approaches: Current Status and Future Perspectives"],"prefix":"10.3390","volume":"2","author":[{"given":"Bin","family":"Zheng","sequence":"first","affiliation":[{"name":"Imaging Research Center, Department of Radiology, University of Pittsburgh, 3362 Fifth Avenue, Room 128, Pittsburgh, PA 15213, USA"}]}],"member":"1968","published-online":{"date-parts":[[2009,6,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1055\/s-0038-1634413","article-title":"Automated semantic indexing of imaging reports to support retrieval of medical images in the multimedia electronic medical record","volume":"38","author":"Love","year":"1999","journal-title":"Meth Inform Med"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1007\/BF03168371","article-title":"Content-based retrieval in picture archiving and communication systems","volume":"13","author":"Xu","year":"2000","journal-title":"J Digit Imaging"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Ogiela, M.R., and Tadeusiewicz, R. 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