{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:08:14Z","timestamp":1760144894942,"version":"build-2065373602"},"reference-count":47,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T00:00:00Z","timestamp":1717027200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["21-71-30023"],"award-info":[{"award-number":["21-71-30023"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computation"],"abstract":"<jats:p>Coronary artery disease (CAD) is one of the main causes of death in the world. Functional indices such as fractional flow reserve (FFR), coronary flow reserve (CFR) and instantaneous wave-free ratio (iFR) are used to estimate the severity of CAD. Approximately 30\u201350% of patients have residual myocardial ischaemia even after formally successful percutaneous coronary intervention (PCI). Myocardial perfusion impairment is one of the main factors responsible for recurrence. We propose a novel 1D model of coronary hemodynamics that takes into account myocardial contraction, stenoses and impaired microcirculation. It uses non-invasively acquired data. The model is able to simulate FFR and iFR with a mean relative error of 3% and a standard mean deviation of 0.04. We find that healthy FFR and iFR values in the short and long term do not always correspond to healthy CFR values and recovery of coronary blood flow. We also show that PCI of stenosis also improves hemodynamic indices in adjacent stenosed vessels, with a more pronounced effect in the long term.<\/jats:p>","DOI":"10.3390\/computation12060110","type":"journal-article","created":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T06:08:14Z","timestamp":1717049294000},"page":"110","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Computational Analysis of Hemodynamic Indices in Multivessel Coronary Artery Disease in the Presence of Myocardial Perfusion Dysfunction"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1914-3859","authenticated-orcid":false,"given":"Timur","family":"Gamilov","sequence":"first","affiliation":[{"name":"Marchuk Institute of Numerical Mathematics of the Russian Academy of Sciences, 119991 Moscow, Russia"},{"name":"Moscow Institute of Physics and Technology, 141701 Dolgoprudny, Russia"},{"name":"World-Class Research Center \u201cDigital Biodesign and Personalized Healthcare\u201d, Sechenov First Moscow State Medical University, 119991 Moscow, Russia"},{"name":"Department of Mathematical Modelling of Processes and Materials, Sirius University of Science and Technology, 354340 Sochi, Russia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4709-4513","authenticated-orcid":false,"given":"Alexander","family":"Danilov","sequence":"additional","affiliation":[{"name":"Marchuk Institute of Numerical Mathematics of the Russian Academy of Sciences, 119991 Moscow, Russia"},{"name":"Institute of Computer Sciences and Mathematical Modelling, Sechenov University, 119991 Moscow, Russia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1485-6072","authenticated-orcid":false,"given":"Peter","family":"Chomakhidze","sequence":"additional","affiliation":[{"name":"World-Class Research Center \u201cDigital Biodesign and Personalized Healthcare\u201d, Sechenov First Moscow State Medical University, 119991 Moscow, Russia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5124-6383","authenticated-orcid":false,"given":"Philipp","family":"Kopylov","sequence":"additional","affiliation":[{"name":"World-Class Research Center \u201cDigital Biodesign and Personalized Healthcare\u201d, Sechenov First Moscow State Medical University, 119991 Moscow, Russia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3406-9623","authenticated-orcid":false,"given":"Sergey","family":"Simakov","sequence":"additional","affiliation":[{"name":"Marchuk Institute of Numerical Mathematics of the Russian Academy of Sciences, 119991 Moscow, Russia"},{"name":"Moscow Institute of Physics and Technology, 141701 Dolgoprudny, Russia"},{"name":"Institute of Computer Sciences and Mathematical Modelling, Sechenov University, 119991 Moscow, Russia"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1056\/NEJM199606273342604","article-title":"Measurement of Fractional Flow Reserve to Assess the Functional Severity of Coronary-Artery Stenoses","volume":"334","author":"Pijls","year":"1996","journal-title":"N. 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