{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:48:55Z","timestamp":1760057335493,"version":"build-2065373602"},"reference-count":55,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computation"],"abstract":"<jats:p>Standing surface acoustic wave (SSAW)-based acoustofluidics is widely used due to its compatibility with soft materials and polymer structures. In the presence of an acoustic field, particles move either toward pressure nodes or anti-nodes according to their contrast factor. Using this technique, blood cells with a certain characteristic can be oriented in different streamlines in a microchannel. The cumulative effect of parameters, such as the inlet velocity ratio of the buffer solution to the blood sample, acoustic frequency, voltage, and channel geometry, is key to effective separation in these microfluidic chips. In this study, simultaneous separation of white blood cells, red blood cells, and platelets in one stage is simulated by means of numerical calculations. The linear constitutive equation for the piezoelectric substrate, the Helmholtz equation for the acoustic field, and the Navier\u2013Stokes equations for fluid mechanics are solved simultaneously to precisely capture the blood cell behavior in the SSAW-based device. The results show that whole blood cell separation can be achieved using a velocity ratio of 6.25, a resonance frequency of 8.28 MHz, and a voltage of 8.5 V in the proposed five-outlet microfluidic chip.<\/jats:p>","DOI":"10.3390\/computation13020042","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T06:30:29Z","timestamp":1738823429000},"page":"42","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Design and Numerical Simulation of a Standing Surface Acoustic Wave-Based Microdevice for Whole Blood Cell Separation"],"prefix":"10.3390","volume":"13","author":[{"given":"Maryam","family":"Hajimoradi","sequence":"first","affiliation":[{"name":"Faculty of Mechanical and Energy Engineering, Shahid Beheshti University, Tehran 1658953571, Iran"}]},{"given":"Moein Talebian","family":"Gevari","sequence":"additional","affiliation":[{"name":"Division of Solid-State Electronics, Department of Electrical Engineering, Uppsala University, 75121 Uppsala, Sweden"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8501-9226","authenticated-orcid":false,"given":"Keith Robert","family":"Pullen","sequence":"additional","affiliation":[{"name":"Department of Engineering, School of Science and Technology, City St George\u2019s, University of London, London EC1V 0HB, UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0065-5467","authenticated-orcid":false,"given":"Mohammad","family":"Mojaddam","sequence":"additional","affiliation":[{"name":"Faculty of Mechanical and Energy Engineering, Shahid Beheshti University, Tehran 1658953571, Iran"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Zhou, J., Mukherjee, P., Gao, H., Luan, Q., and Papautsky, I. 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