{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:11:36Z","timestamp":1760029896303,"version":"build-2065373602"},"reference-count":21,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T00:00:00Z","timestamp":1738886400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computation"],"abstract":"<jats:p>Understanding the transport of small molecules such as oxygen in biological systems requires knowledge about how molecules dynamically interact with these molecules. This study investigates how red blood cells influence the diffusion of small molecules in simple shear flow by coupling Brownian dynamics simulations with a finite element\u2013boundary integral method to simulate particle transport near spherical and red blood cells. The simulation found that the presence of a rotating cell significantly reduces the effective diffusion rate of small molecules. Specifically, the circulatory flow induced by cell deformation during tank-treading motion leads to a diminished mean squared displacement of particles. Notably, a tumbling red blood cell produces a more pronounced effect on particle motion compared with a spherical cell under identical flow conditions. This research has broader implications for understanding complex diffusion processes in various biological systems, by highlighting the complex interactions between cellular motion and molecular transport.<\/jats:p>","DOI":"10.3390\/computation13020047","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T10:07:56Z","timestamp":1738922876000},"page":"47","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Transport Characteristics of Small Molecules Diffusing near Deforming Blood Cells"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7660-0721","authenticated-orcid":false,"given":"Stephanie","family":"Nix","sequence":"first","affiliation":[{"name":"Faculty of Software and Information Science, Iwate Prefectural University, Takizawa 152252, Japan"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/cphy.c160006","article-title":"Ischemia\/Reperfusion","volume":"7","author":"Kalogeris","year":"2016","journal-title":"Compr. 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