{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T08:23:47Z","timestamp":1770884627445,"version":"3.50.1"},"reference-count":31,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T00:00:00Z","timestamp":1555286400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computation"],"abstract":"<jats:p>In this paper, we propose and investigate a diffusive viral infection model with distributed delays and cytotoxic T lymphocyte (CTL) immune response. Also, both routes of infection that are virus-to-cell infection and cell-to-cell transmission are modeled by two general nonlinear incidence functions. The well-posedness of the proposed model is also proved by establishing the global existence, uniqueness, nonnegativity and boundedness of solutions. Moreover, the threshold parameters and the global asymptotic stability of equilibria are obtained. Furthermore, diffusive and delayed virus dynamics models presented in many previous studies are improved and generalized.<\/jats:p>","DOI":"10.3390\/computation7020021","type":"journal-article","created":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T11:15:58Z","timestamp":1555326958000},"page":"21","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Spatiotemporal Dynamics of a Generalized Viral Infection Model with Distributed Delays and CTL Immune Response"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5032-3639","authenticated-orcid":false,"given":"Khalid","family":"Hattaf","sequence":"first","affiliation":[{"name":"Centre R\u00e9gional des M\u00e9tiers de l\u2019Education et de la Formation (CRMEF), 20340 Derb Ghalef, Casablanca, Morocco"},{"name":"Laboratory of Analysis, Modeling and Simulation (LAMS), Faculty of Sciences Ben M\u2019sik, Hassan II University, P.O. Box 7955, Sidi Othman, Casablanca, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,4,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1126\/science.272.5258.74","article-title":"Population dynamics of immune responses to persistent viruses","volume":"272","author":"Nowak","year":"1996","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/PL00008847","article-title":"Dose effects and density-dependent regulation of two microparasites of Daphnia magna","volume":"122","author":"Ebert","year":"2000","journal-title":"Oecologia"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1098\/rstb.2000.0641","article-title":"Scrapie infections initiated at varying doses: An analysis of 117 titration experiments","volume":"355","author":"Mclean","year":"2000","journal-title":"Philos. Trans. Roy. Soc. London Ser. 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