{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T23:12:29Z","timestamp":1763766749947,"version":"build-2065373602"},"reference-count":37,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T00:00:00Z","timestamp":1566950400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"B\u00f6hringer Ingelheim Foundation","award":["Plus3 program"],"award-info":[{"award-number":["Plus3 program"]}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC765"],"award-info":[{"award-number":["CRC765"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computation"],"abstract":"<jats:p>In addition to the conventional Isothermal Titration Calorimetry (ITC), kinetic ITC (kinITC) not only gains thermodynamic information, but also kinetic data from a biochemical binding process. Moreover, kinITC gives insights into reactions consisting of two separate kinetic steps, such as protein folding or sequential binding processes. The ITC method alone cannot deliver kinetic parameters, especially not for multivalent bindings. This paper describes how to solve the problem using kinITC and an invariant subspace projection. The algorithm is tested for multivalent systems with different valencies.<\/jats:p>","DOI":"10.3390\/computation7030046","type":"journal-article","created":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T11:23:18Z","timestamp":1566991398000},"page":"46","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Modeling of Multivalent Ligand-Receptor Binding Measured by kinITC"],"prefix":"10.3390","volume":"7","author":[{"given":"Franziska","family":"Erlekam","sequence":"first","affiliation":[{"name":"Zuse Institute Berlin, Numerical Mathematics Department, Computational Molecular Design, Takustra\u00dfe 7, 14195 Berlin, Germany"}]},{"given":"Sinaida","family":"Igde","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Organische und Makromolekulare Chemie, Heinrich-Heine-Universit\u00e4t D\u00fcsseldorf, 40225 D\u00fcsseldorf, Germany"}]},{"given":"Susanna","family":"R\u00f6blitz","sequence":"additional","affiliation":[{"name":"Computational Biology Unit, Department of Informatics, University of Bergen, Thorm\u00f8hlensgate 55, 5006 Bergen, Norway"}]},{"given":"Laura","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Organische und Makromolekulare Chemie, Heinrich-Heine-Universit\u00e4t D\u00fcsseldorf, 40225 D\u00fcsseldorf, Germany"}]},{"given":"Marcus","family":"Weber","sequence":"additional","affiliation":[{"name":"Zuse Institute Berlin, Numerical Mathematics Department, Computational Molecular Design, Takustra\u00dfe 7, 14195 Berlin, Germany"}]}],"member":"1968","published-online":{"date-parts":[[2019,8,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1021\/cr000418f","article-title":"The cluster glycoside effect","volume":"102","author":"Lundquist","year":"2002","journal-title":"Chem. 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