{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:39:35Z","timestamp":1759365575624,"version":"build-2065373602"},"reference-count":42,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"national funds through FCT\u2013Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["UIDB\/04630\/2020","UIDB\/00127\/2020"],"award-info":[{"award-number":["UIDB\/04630\/2020","UIDB\/00127\/2020"]}]}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Computers"],"abstract":"<jats:p>Modern custom machine construction and automation projects face pressure to shorten innovation cycles, reduce durations, and manage growing system complexity. Traditional methods like Waterfall and V-Model have limits where end-to-end data traceability is vital throughout the product life cycle. This study introduces the implementation of a web application that incorporates a model-based design approach to assess its applicability and effectiveness in conceptual design scenarios. At the heart of this approach is the Case-Based Axiomatic Design Assistant (CADA), which utilizes Axiomatic Design principles to break down complex tasks into structured, analyzable sub-concepts. It also incorporates Case-Based Reasoning (CBR) to systematically store and reuse design knowledge. The effectiveness of the visual assistant was evaluated through expert-led assessments across different fields. The results revealed a significant reduction in design effort when utilising prior knowledge, thus validating both the efficiency of CADA as a model and the effectiveness of its implementation within a user-centric application, highlighting its collaborative features. The findings support this approach as a scalable solution for enhancing conceptual design quality, facilitating knowledge reuse, and promoting agile development.<\/jats:p>","DOI":"10.3390\/computers14100415","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T07:58:13Z","timestamp":1759305493000},"page":"415","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Applying the Case-Based Axiomatic Design Assistant (CADA) to a Pharmaceutical Engineering Task: Implementation and Assessment"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3063-6264","authenticated-orcid":false,"given":"Roland","family":"W\u00f6lfle","sequence":"first","affiliation":[{"name":"Doctoral School, University of Aveiro, Campus Universit\u00e1rio de Santiago, 3810-193 Aveiro, Portugal"},{"name":"Pester Pac Automation GmbH, Hauptstra\u00dfe 50, 87787 Wolfertschwenden, Germany"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0625-1279","authenticated-orcid":false,"given":"Irina","family":"Saur-Amaral","sequence":"additional","affiliation":[{"name":"Superior Institute of Accounting and Business, University of Aveiro, Campus Universit\u00e1rio de Santiago, 3810-193 Aveiro, Portugal"},{"name":"Research Center for Business Sciences (NECE), Universidade da Beira Interior, Estrada do Sineiro 56, 6200-209 Covilh\u00e3, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7791-1932","authenticated-orcid":false,"given":"Leonor","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Department of Economics, Management and Industrial Engineering and Tourism (DEGEIT), University of Aveiro, Campus Universit\u00e1rio de Santiago, 3810-193 Aveiro, Portugal"},{"name":"Institute of Electronics and Informatics Engineering of Aveiro (IEETA), University of Aveiro, Campus Universit\u00e1rio de Santiago, 3810-193 Aveiro, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"103759","DOI":"10.1016\/j.drudis.2023.103759","article-title":"Impact of GAMP 5, data integrity and QbD on quality assurance in the pharmaceutical industry: How obvious is it?","volume":"28","author":"Pedro","year":"2023","journal-title":"Drug Discov. 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