{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T04:51:29Z","timestamp":1769921489717,"version":"3.49.0"},"reference-count":50,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:00:00Z","timestamp":1759363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Computers"],"abstract":"<jats:p>Because of the increased prevalence of chronic diseases, older adults frequently take many medications. However, adhering to a medication treatment tends to be difficult. The lack of medication adherence can cause health problems or even patient death. This paper describes the methodology used in developing a mobile augmented reality (MAR) pill box. The proposal supports patients in adhering to their medication treatment. First, we explain the design and construction of the automatic pill box, which includes alarms and uses QR codes recognized by the MAR system to provide medication information. Then, we explain the development of the MAR system. We conducted a preliminary survey with 30 participants to assess the feasibility of the MAR app. One hundred older adults participated in the survey. After one week of using the proposal, each patient answered a survey regarding the proposal functionality. The results revealed that 88% of the participants strongly agree and 11% agree that the app is a support in adhering to medical treatment. Finally, we conducted a study to compare the time elapsed between the scheduled time for taking the medication and the time it was actually consumed. The results from 189 records showed that using the proposal, 63.5% of the patients take medication with a maximum delay of 4.5 min. The results also showed that the alarm always sounded at the scheduled time and that the QR code displayed always corresponded to the medication that had to be consumed.<\/jats:p>","DOI":"10.3390\/computers14100421","type":"journal-article","created":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T15:07:48Z","timestamp":1759417668000},"page":"421","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Study to Determine the Feasibility of Combining Mobile Augmented Reality and an Automatic Pill Box to Support Older Adults\u2019 Medication Adherence"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6572-6596","authenticated-orcid":false,"given":"Osslan Osiris","family":"Vergara-Villegas","sequence":"first","affiliation":[{"name":"Instituto de Ingenier\u00eda y Tecnolog\u00eda, Universidad Aut\u00f3noma de Ciudad Ju\u00e1rez, Ciudad Ju\u00e1rez 32310, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6874-8072","authenticated-orcid":false,"given":"Vianey Guadalupe","family":"Cruz-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Instituto de Ingenier\u00eda y Tecnolog\u00eda, Universidad Aut\u00f3noma de Ciudad Ju\u00e1rez, Ciudad Ju\u00e1rez 32310, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8351-2137","authenticated-orcid":false,"given":"Abel Alejandro","family":"Rub\u00edn-Alvarado","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Computaci\u00f3n, Instituto Polit\u00e9cnico Nacional, Mexico City 07738, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6012-4003","authenticated-orcid":false,"given":"Saulo Abraham","family":"Gante-D\u00edaz","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Computaci\u00f3n, Instituto Polit\u00e9cnico Nacional, Mexico City 07738, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4222-0573","authenticated-orcid":false,"given":"Jonathan Axel","family":"Cruz-Vazquez","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Computaci\u00f3n, Instituto Polit\u00e9cnico Nacional, Mexico City 07738, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7200-0556","authenticated-orcid":false,"given":"Brandon","family":"Areyzaga-Mendiz\u00e1bal","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Computaci\u00f3n, Instituto Polit\u00e9cnico Nacional, Mexico City 07738, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0214-1080","authenticated-orcid":false,"given":"Jes\u00fas Yalj\u00e1","family":"Montiel-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Computaci\u00f3n, Instituto Polit\u00e9cnico Nacional, Mexico City 07738, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0521-4898","authenticated-orcid":false,"given":"Juan Humberto","family":"Sossa-Azuela","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Computaci\u00f3n, Instituto Polit\u00e9cnico Nacional, Mexico City 07738, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9552-8208","authenticated-orcid":false,"given":"Iliac","family":"Huerta-Trujillo","sequence":"additional","affiliation":[{"name":"Unidad Profesional Interdisciplinaria en Ingenier\u00eda y Tecnolog\u00edas Avanzadas, Instituto Polit\u00e9cnico Nacional, Mexico City 07738, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9473-8927","authenticated-orcid":false,"given":"Rodolfo","family":"Romero-Herrera","sequence":"additional","affiliation":[{"name":"Escuela Superior de C\u00f3mputo, Instituto Polit\u00e9cnico Nacional, Mexico City 07738, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,2]]},"reference":[{"key":"ref_1","unstructured":"WHO (2025, June 05). Ageing and Health, Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/ageing-and-health."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Franceschi, C., Garagnani, P., Morsiani, C., Conte, M., Santoro, A., Grignolio, A., Monti, D., Capri, M., and Salvioli, S. (2018). The continuum of aging and age-related diseases: Common mechanisms but different rates. Front. Med., 5.","DOI":"10.3389\/fmed.2018.00061"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1007\/s11096-007-9148-5","article-title":"Understanding the meaning of medications for patients: The medication experience","volume":"30","author":"Shoemaker","year":"2008","journal-title":"Pharm. World Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejim.2023.07.008","article-title":"The role of adherence in patients with chronic diseases","volume":"119","author":"Burnier","year":"2024","journal-title":"Eur. J. Intern. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/s41569-023-00972-1","article-title":"Improving medication adherence in cardiovascular disease","volume":"21","author":"Nelson","year":"2024","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1007\/s11606-020-06447-0","article-title":"The impact of social determinants of health on medication adherence: A systematic review and meta-analysis","volume":"36","author":"Wilder","year":"2021","journal-title":"J. Gen. Intern. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.2147\/PPA.S368784","article-title":"A Critical review of medication adherence in hypertension: Barriers and facilitators clinicians should consider","volume":"16","author":"Mehrdad","year":"2022","journal-title":"Patient Prefer. Adherence"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ejim.2023.10.012","article-title":"From non-adherence to adherence: Can innovative solutions resolve a longstanding problem?","volume":"119","author":"Kardas","year":"2024","journal-title":"Eur. J. Intern. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e35157","DOI":"10.2196\/35157","article-title":"Technologies for medication adherence monitoring and technology assessment criteria: Narrative review","volume":"10","author":"Mason","year":"2022","journal-title":"JMIR Mhealth Uhealth"},{"key":"ref_10","first-page":"49","article-title":"Monitoring technologies for quantifying medication adherence","volume":"Volume 1","author":"Wac","year":"2022","journal-title":"Quantifying Quality of Life: Incorporating Daily Life into Medicine"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Pratiwi, H., Kristina, S., Widayanti, A., Prabandari, Y., and Kusuma, I. (2023). A systematic review of compensation and technology-mediated strategies to maintain older adults\u2019 medication adherence. Int. J. Environ. Res. Public Health, 20.","DOI":"10.3390\/ijerph20010803"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Horvat, M., Er\u017een, I., and Vrbnjak, D. (2024). Barriers and facilitators to medication adherence among the vulnerable elderly: A focus group study. Healthcare, 12.","DOI":"10.3390\/healthcare12171723"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1093\/geront\/gnab167","article-title":"Digital ageism: Challenges and opportunities in artificial intelligence for older adults","volume":"62","author":"Chu","year":"2022","journal-title":"Gerontologist"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1145\/2399193.2399195","article-title":"How older adults learn to use mobile devices: Survey and field investigations","volume":"4","author":"Leung","year":"2012","journal-title":"ACM Trans. Access. Comput. (TACCESS)"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"106783","DOI":"10.1016\/j.chb.2021.106783","article-title":"Smartphone usage among older adults","volume":"4","author":"Busch","year":"2021","journal-title":"Comput. Hum. Behav."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e618","DOI":"10.7717\/peerj-cs.618","article-title":"Effects of using mobile augmented reality for simple interest computation in a financial mathematics course","volume":"7","author":"Tovar","year":"2021","journal-title":"PeerJ Comput. Sci."},{"key":"ref_17","unstructured":"Vergara, O., and Cruz, V. (2024). Augmented Reality: Fundamentals and Applications, CRC Press."},{"key":"ref_18","first-page":"e65","article-title":"Designing and evaluating digital therapeutic interventions using virtual and augmented reality to improve medication adherence, patient education, and chronic disease self-management","volume":"3","author":"Ikram","year":"2025","journal-title":"J. Health Wellness Community Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1049\/smc2.12062","article-title":"Developing an integrated medication adherence system: Exploring the potential of i-are\u2019s augmented reality goggles and mobile application","volume":"5","author":"Taghian","year":"2023","journal-title":"IET Smart Cities"},{"key":"ref_20","unstructured":"Franz\u00e9n, J. (2023). MedinAR: A Mobile Augmented Reality Concept for Medication Adherence. [Ph.D. Thesis, Malm\u00f6 University]."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Yang, S., Pang, X., and He, X. (2021, January 24\u201329). A novel mobile application for medication adherence supervision based on AR and OpenCV designed for elderly patient. Proceedings of the 7th Human Aspects of IT for the Aged Population (ITAP), Virtual Event.","DOI":"10.1007\/978-3-030-78111-8_23"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.1007\/s11606-021-06648-1","article-title":"An adaptable framework for factors contributing to medication adherence: Results from a systematic review of 102 conceptual frameworks","volume":"36","author":"Peh","year":"2021","journal-title":"J. Gen. Intern. Med."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Green, E.C., Murphy, E.M., and Gryboski, K. (2020). The health belief model. The Wiley Encyclopedia of Health Psychology, Wiley.","DOI":"10.1002\/9781119057840.ch68"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Yin, W., and Fresco, P. (2015). Medication adherence measures: An overview. BioMed Res. Int., 2015.","DOI":"10.1155\/2015\/217047"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/jebm.12548","article-title":"Exploring patient medication adherence and data mining methods in clinical bigdata: A contemporary review","volume":"16","author":"Xu","year":"2023","journal-title":"J.-Evid.-Based Med."},{"key":"ref_26","unstructured":"Thangam, S., Reddy, T., Krithin, T., and Kumari, J. (2024, January 7\u20139). A smart pill container for improved medication. Proceedings of the 2024 5th International Conference on Electronics and Sustainable Communication Systems (ICESC), Coimbatore, India."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.glohj.2021.11.006","article-title":"A review on emerging smart technological innovations in healthcare sector for increasing patient\u2019s medication adherence","volume":"5","author":"Pal","year":"2021","journal-title":"Glob. Health J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1177\/1060028020950726","article-title":"Impact of telehealth interventions on medication adherence for patients with type 2 diabetes, hypertension, and\/or dyslipidemia: A systematic review","volume":"55","author":"Bingham","year":"2021","journal-title":"Ann. Pharmacother."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e2200107","DOI":"10.1200\/CCI.22.00107","article-title":"Detection of medication taking using a wrist-worn commercially available wearable device","volume":"7","author":"Laughlin","year":"2023","journal-title":"JCO Clin. Cancer Inform."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"11","DOI":"10.2147\/PPA.S337117","article-title":"Exploring stem cell transplanted Patients\u2019 perspectives on medication self-management and electronic monitoring devices measuring medication adherence: A qualitative sub-study of the Swiss SMILe implementation science project","volume":"16","author":"Ribaut","year":"2022","journal-title":"Patient Prefer. Adherence"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Pinto, J., Vilaca, J., and Dias, N. (2021, January 4\u20136). A review of current pill organizers and dispensers. Proceedings of the IEEE 9th International Conference on Serious Games and Applications for Health (SeGAH), Dubai, United Arab Emirates.","DOI":"10.1109\/SEGAH52098.2021.9551894"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"\u017bur, P. (2023). Combination of a DC motor controller and telemetry system to optimize energy consumption. Sensors, 23.","DOI":"10.3390\/s23156923"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/jcal.12617","article-title":"The impact of augmented reality on cognitive load and performance: A systematic review","volume":"38","author":"Buchner","year":"2022","journal-title":"J. Comput. Assist. Learn."},{"key":"ref_34","first-page":"20552076221132099","article-title":"Virtual and augmented reality applications to improve older adults\u2019 quality of life: A systematic mapping review and future directions","volume":"8","author":"Baragash","year":"2022","journal-title":"Digit. Health"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Lee, L., Kim, M., and Hwang, W. (2019). Potential of augmented reality and virtual reality technologies to promote wellbeing in older adults. Appl. Sci., 9.","DOI":"10.3390\/app9173556"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e22007","DOI":"10.2196\/22007","article-title":"A cognitive-based board game with augmented reality for older adults: Development and usability study","volume":"8","author":"Chen","year":"2020","journal-title":"JMIR Serious Games"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1001\/jamainternmed.2017.3919","article-title":"Use of health care databases to support supplemental indications of approved medications","volume":"178","author":"Fralick","year":"2018","journal-title":"JAMA Int. Med."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Borsting, I., Karabulut, C., Fischer, B., and Gruhn, V. (2022). Design patterns for mobile augmented reality user interfaces\u2014An incremental review. Information, 13.","DOI":"10.3390\/info13040159"},{"key":"ref_39","first-page":"012066","article-title":"Design and development of Android application for educational institutes","volume":"1769","author":"Ejiyi","year":"2021","journal-title":"J. Phys."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.ijmedinf.2015.02.001","article-title":"Use of QR and EAN-13 codes by older patients taking multiple medications for a safer use of medication","volume":"84","author":"Mira","year":"2015","journal-title":"Int. J. Med. Inform."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Rivas, A., and Schulzetenberg, A. (2023, January 4\u20136). QR codes as a method for older adults to access a mobile survey. Proceedings of the International Conference on Human-Computer Interaction, Lleida, Spain.","DOI":"10.1007\/978-3-031-34866-2_10"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Morrison, B., Nicholson, J., Wood, B., and Briggs, P. (2023). Life after lockdown: The experiences of older adults in a contactless digital world. Front. Psychol., 13.","DOI":"10.3389\/fpsyg.2022.1100521"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"3810","DOI":"10.1109\/TVCG.2022.3203103","article-title":"Quantifying the effects of working in VR for one week","volume":"28","author":"Biener","year":"2022","journal-title":"IEEE Trans. Vis. Comput. Graph."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"120205","DOI":"10.1016\/j.energy.2021.120205","article-title":"Early prediction of battery lifetime via a machine learning based framework","volume":"225","author":"Fei","year":"2021","journal-title":"Energy"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1007\/s11036-018-1083-2","article-title":"A hybrid key item locating method to assist elderly daily life using internet of things","volume":"24","author":"Hung","year":"2019","journal-title":"Mob. Netw. Appl."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Divya, R., Shree, S., Sakthiganesh, V., Gokulkumar, K., and Monisha, A. (2025). Digital Pills: Enhancing patient outcomes through innovative medication management. Comput. Biol. Med., 196.","DOI":"10.1016\/j.compbiomed.2025.110907"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1109\/MPRV.2024.3364541","article-title":"Preference in voice commands and gesture controls with hands-free augmented reality with novel users","volume":"23","author":"Korkiakoski","year":"2024","journal-title":"IEEE Pervasive Comput."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Rodriguez, A., Vergara, O., Nandayapa, M., Garcia, F., and Guevara, M. (2025). A Diamond Approach to Develop Virtual Object Interaction: Fusing Augmented Reality and Kinesthetic Haptics. Multimodal Technol. Interact., 9.","DOI":"10.3390\/mti9020015"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"102080","DOI":"10.1016\/j.techsoc.2022.102080","article-title":"Technology use characteristics among older adults during the COVID-19 pandemic: A cross-cultural survey","volume":"71","author":"Elimelech","year":"2022","journal-title":"Technol. Soc."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.bushor.2021.02.027","article-title":"Strategies for the successful implementation of augmented reality","volume":"64","author":"Berman","year":"2021","journal-title":"Bus. 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