{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T05:03:26Z","timestamp":1779944606512,"version":"3.53.1"},"reference-count":50,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computers"],"abstract":"<jats:p>Academic stress in higher education is strongly influenced by workload structure and scheduling decisions, yet academic planning sometimes remains static and does not incorporate behavioural or physiological indicators. While existing research focuses on stress measurement and prediction, these approaches are rarely integrated into decision-support mechanisms capable of restructuring academic schedules. This work introduces a Course Digital Twin (CDT) framework that integrates multimodal student data with simulation-based academic planning. The proposed system models course scheduling as a decision-support problem, where alternative configurations are evaluated using a structured stress model combining wearable-derived physiological signals, self-reported stress measures, and contextual academic workload indicators. The framework employs a hybrid approach in which machine learning is used for physiological stress estimation, while schedule adaptation is performed through transparent rule-based mechanisms. The system was implemented as an end-to-end platform including mobile sensing, course configuration interfaces, and instructor analytics dashboards, and was evaluated through a pilot deployment across multiple postgraduate courses. Preliminary results indicate that simulation-based schedule adjustments are associated with reductions in projected peak stress levels and improved workload distribution patterns. The findings demonstrate the feasibility of integrating multimodal stress modelling and Digital Twin simulation into academic planning workflows. The proposed framework provides a foundation for future stress-aware scheduling systems, although further large-scale validation is required to establish its effectiveness and generalizability.<\/jats:p>","DOI":"10.3390\/computers15060338","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T08:16:08Z","timestamp":1779783368000},"page":"338","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Multimodal Course Digital Twin for Adaptive Academic Planning: Integrating Physiological Stress, Self-Reports, and Academic Context"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5042-9408","authenticated-orcid":false,"given":"Stamatios","family":"Orfanos","sequence":"first","affiliation":[{"name":"BioAssist, Kastritsiou 4, 26504 Patras, Greece"},{"name":"Department of Digital Systems, University of Piraeus, 18534 Piraeus, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8630-7200","authenticated-orcid":false,"given":"Parisis","family":"Gallos","sequence":"additional","affiliation":[{"name":"Department of Digital Systems, University of Piraeus, 18534 Piraeus, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9282-0919","authenticated-orcid":false,"given":"Christos","family":"Panagopoulos","sequence":"additional","affiliation":[{"name":"BioAssist, Kastritsiou 4, 26504 Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4510-5522","authenticated-orcid":false,"given":"Andreas","family":"Menychtas","sequence":"additional","affiliation":[{"name":"Department of Digital Systems, University of Piraeus, 18534 Piraeus, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2860-399X","authenticated-orcid":false,"given":"Ilias","family":"Maglogiannis","sequence":"additional","affiliation":[{"name":"Department of Digital Systems, University of Piraeus, 18534 Piraeus, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1111\/jcpp.13606","article-title":"Prevalence and associated factors of depression and anxiety symptoms among college students: A systematic review and meta-analysis","volume":"63","author":"Li","year":"2022","journal-title":"J. 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