{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T02:11:33Z","timestamp":1769825493054,"version":"3.49.0"},"reference-count":47,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2019,12,14]],"date-time":"2019-12-14T00:00:00Z","timestamp":1576281600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DFG SCHU 2271\/6-2"],"award-info":[{"award-number":["DFG SCHU 2271\/6-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007636","name":"Deutsche Bundesstiftung Umwelt","doi-asserted-by":"publisher","award":["20019\/593"],"award-info":[{"award-number":["20019\/593"]}],"id":[{"id":"10.13039\/100007636","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Data"],"abstract":"<jats:p>Regulatory threshold levels (RTL) represent robust benchmarks for assessing risks of pesticides, e.g., in surface waters. However, comprehensive scientific risk evaluations comparing RTL to measured environmental concentrations (MEC) of pesticides in surface waters were yet restricted to a low number of pesticides, as RTL are only available after extensive review of regulatory documents. Thus, the aim of the present study was to model RTL equivalents (RTLe) for aquatic organisms from publicly accessible ecotoxicological effect databases. We developed a model that applies validity criteria in accordance with official US EPA review guidelines and validated the model against a set of manually retrieved RTL (n = 49). Model application yielded 1283 RTLe (n = 676 for pesticides, plus 607 additional RTLe for other use types). In a case study, the usability of RTLe was demonstrated for a set of 27 insecticides by comparing RTLe and RTL exceedance rates for 3001 MEC from US surface waters. The provided dataset enables thorough risk assessments of surface water exposure data for a comprehensive number of substances. Especially regions without established pesticide regulations may benefit from this dataset by using it as a baseline information for pesticide risk assessment and for the identification of priority substances or potential high-risk regions.<\/jats:p>","DOI":"10.3390\/data4040150","type":"journal-article","created":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T02:59:01Z","timestamp":1576551541000},"page":"150","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Modeling Regulatory Threshold Levels for Pesticides in Surface Waters from Effect Databases"],"prefix":"10.3390","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2831-1962","authenticated-orcid":false,"given":"Lara","family":"Petschick","sequence":"first","affiliation":[{"name":"iES Landau, Institute for Environmental Sciences, University of Koblenz-Landau, D-76829 Landau, Germany"}]},{"given":"Sascha","family":"Bub","sequence":"additional","affiliation":[{"name":"iES Landau, Institute for Environmental Sciences, University of Koblenz-Landau, D-76829 Landau, Germany"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0211-2191","authenticated-orcid":false,"given":"Jakob","family":"Wolfram","sequence":"additional","affiliation":[{"name":"iES Landau, Institute for Environmental Sciences, University of Koblenz-Landau, D-76829 Landau, Germany"}]},{"given":"Sebastian","family":"Stehle","sequence":"additional","affiliation":[{"name":"iES Landau, Institute for Environmental Sciences, University of Koblenz-Landau, D-76829 Landau, Germany"},{"name":"Eusserthal Ecosystem Research Station, University of Koblenz-Landau, D-76857 Eusserthal, Germany"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6348-6971","authenticated-orcid":false,"given":"Ralf","family":"Schulz","sequence":"additional","affiliation":[{"name":"iES Landau, Institute for Environmental Sciences, University of Koblenz-Landau, D-76829 Landau, Germany"}]}],"member":"1968","published-online":{"date-parts":[[2019,12,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1017\/S0021859605005708","article-title":"Crop losses to pests","volume":"144","author":"Oerke","year":"2006","journal-title":"J. Agric. Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s13593-012-0105-x","article-title":"Pesticide productivity and food security. A review","volume":"33","author":"Popp","year":"2013","journal-title":"Agron. Sustain. Dev."},{"key":"ref_3","unstructured":"Food and Agriculture Organization of the United Nations (FAO) (2019, November 01). FAO FAOSTAT Database. Available online: http:\/\/www.fao.org\/faostat\/en\/\\#data\/EL."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1002\/etc.2170","article-title":"Current-use pesticides in stream water and suspended particles following runoff: Exposure, effects, and mitigation requirements","volume":"32","author":"Bereswill","year":"2013","journal-title":"Environ. Toxicol. Chem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"11025","DOI":"10.1021\/es5025367","article-title":"Pesticides in U.S. Streams and Rivers: Occurrence and trends during 1992\u20132011","volume":"48","author":"Stone","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.envpol.2016.09.085","article-title":"Complex mixtures of Pesticides in Midwest US streams indicated by POCIS time-integrating samplers","volume":"220","author":"Alvarez","year":"2017","journal-title":"Environ. Pollut."},{"key":"ref_7","unstructured":"FIFRA (1947). Federal Insecticide, Fungicide and Rodenticide act. U.S. Federal Law, Amended in 1972 and 1988, FIFRA."},{"key":"ref_8","unstructured":"U.S. Environmental Protection Agency (2019, October 30). Reregistration and Other Review Programs Predating Pesticide Registration Review, Available online: https:\/\/www.epa.gov\/pesticide-reevaluation\/reregistration-and-other-review-programs-predating-pesticide-registration."},{"key":"ref_9","unstructured":"U.S. Environmental Protection Agency (2004). Overview of the Ecological Risk Assessment Process in the Office of Pesticide Programs, US Environmental Protection Agency Endangered and Threatened Species Effects Determinations."},{"key":"ref_10","unstructured":"U.S. Environmental Protection Agency (2016). Ecological Effects Test Guidelines OCSPP 850.1075: Freshwater and Saltwater Fish Acute Toxicity Test."},{"key":"ref_11","unstructured":"U.S. Environmental Protection Agency (2016). Ecological Effects Test Guidelines OCSPP 850.1010: Aquatic Invertebrate Acute Toxicity Test, Freshwater Daphnids."},{"key":"ref_12","unstructured":"U.S. Environmental Protection Agency (2012). Ecological Effects Test Guidelines OCSPP 850.4400: Aquatic Plant Toxicity Test Using Lemna spp."},{"key":"ref_13","unstructured":"U.S. Environmental Protection Agency (2012). Ecological Effects Test Guidelines OCSPP 850.4500: Algal Toxicity."},{"key":"ref_14","unstructured":"(2018, March 30). US EPA Evaluation Guidelines for Ecological Toxicity Data in the Open Literature, Available online: https:\/\/www.epa.gov\/pesticide-science-and-assessing-pesticide-risks\/evaluation-guidelines-ecological-toxicity-data-open."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"14452","DOI":"10.1021\/acs.est.8b04651","article-title":"Meta-analysis of insecticides in United States surface waters: Status and future implications","volume":"52","author":"Wolfram","year":"2018","journal-title":"Environ. Sci. Technol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"5750","DOI":"10.1073\/pnas.1500232112","article-title":"Agricultural insecticides threaten surface waters at the global scale","volume":"112","author":"Stehle","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0166-445X(99)00002-8","article-title":"A field study of the effects of agriculturally derived insecticide input on stream macroinvertebrate dynamics","volume":"46","author":"Schulz","year":"1999","journal-title":"Aquat. Toxicol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.scitotenv.2011.05.063","article-title":"Effects of pesticide toxicity, salinity and other environmental variables on selected ecosystem functions in streams and the relevance for ecosystem services","volume":"415","author":"Bundschuh","year":"2012","journal-title":"Sci. Total Environ."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.scitotenv.2007.04.040","article-title":"Effects of pesticides on community structure and ecosystem functions in agricultural streams of three biogeographical regions in Europe","volume":"382","author":"Caquet","year":"2007","journal-title":"Sci. Total Environ."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"11039","DOI":"10.1073\/pnas.1305618110","article-title":"Pesticides reduce regional biodiversity of stream invertebrates","volume":"110","author":"Beketov","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1021\/es103227q","article-title":"Effects of pesticides monitored with three sampling methods in 24 sites on macroinvertebrates and microorganisms","volume":"45","author":"Pettigrove","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1002\/etc.3721","article-title":"Postregistration monitoring of pesticides is urgently required to protect ecosystems","volume":"36","author":"Vijver","year":"2017","journal-title":"Environ. Toxicol. Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"9549","DOI":"10.1073\/pnas.1321082111","article-title":"Organic chemicals jeopardize the health of freshwater ecosystems on the continental scale","volume":"111","author":"Malaj","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.envint.2014.10.024","article-title":"Neonicotinoid contamination of global surface waters and associated risk to aquatic invertebrates: A review","volume":"74","author":"Morrissey","year":"2015","journal-title":"Environ. Int."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"670","DOI":"10.2307\/1310388","article-title":"The myth of the most sensitive species","volume":"36","author":"Cairns","year":"1986","journal-title":"BioScience"},{"key":"ref_26","unstructured":"U.S. Environmental Protection Agency (2018, March 02). Pesticides Chemical Search | Chemical Search | Pesticides | US EPA, Available online: https:\/\/iaspub.epa.gov\/apex\/pesticides\/f?p=chemicalsearch:1."},{"key":"ref_27","unstructured":"U.S. Environmental Protection Agency (2018, March 02). US EPA\u2019s Web Archive: Pesticide Reregistration Status, Available online: https:\/\/archive.epa.gov\/pesticides\/reregistration\/web\/html\/status.html."},{"key":"ref_28","unstructured":"U.S. Environmental Protection Agency (2019, October 31). Aquatic Life Benchmarks and Ecological Risk Assessments for Registered Pesticides, Available online: https:\/\/www.epa.gov\/pesticide-science-and-assessing-pesticide-risks\/aquatic-life-benchmarks-and-ecological-risk."},{"key":"ref_29","unstructured":"U.S. Environmental Protection Agency (2007). Special Docket for Pesticide Reregistration Risk Assessments-Risk Assessments and Related Documents (DVD Set)."},{"key":"ref_30","unstructured":"U.S. Environmental Protection Agency (2019, October 23). Registration Review Process, Available online: https:\/\/www.epa.gov\/pesticide-reevaluation\/registration-review-process."},{"key":"ref_31","unstructured":"U.S. Environmental Protection Agency (2019, November 01). (2019) ECOTOX User Guide: ECOTOXicology Knowledgebase System, Available online: http:\/www.epa.gov\/ecotox\/ 2019."},{"key":"ref_32","unstructured":"U.S. Environmental Protection Agency (2019, November 01). (2019) USEPA Pesticide Ecotoxicity Database, Available online: https:\/\/ecotox.ipmcenters.org\/index.cfm?menuid=7."},{"key":"ref_33","unstructured":"U.S. Environmental Protection Agency (2016). Ecological Effects Test Guidelines OCSPP 850.1020: Gammarid Amphipod Acute Toxicity Test."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1002\/etc.2955","article-title":"Stepwise Information-Filtering Tool (SIFT): A method for using risk assessment metadata in a nontraditional way: Stepwise Information-Filtering Tool (SIFT)","volume":"34","author":"Beasley","year":"2015","journal-title":"Environ. Toxicol. Chem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1002\/etc.4382","article-title":"Creation of a curated aquatic toxicology database: EnviroTox","volume":"38","author":"Connors","year":"2019","journal-title":"Environ. Toxicol. Chem."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Bub, S., Wolfram, J., Stehle, S., Petschick, L.L., and Schulz, R. (2019). Graphing ecotoxicology: The MAGIC Graph for linking environmental data on chemicals. Data, 4.","DOI":"10.3390\/data4010034"},{"key":"ref_37","unstructured":"U.S. Environmental Protection Agency (2010). Environmental Fate and Ecological Risk Assessment Problem Formulation. In Support of Registration Review of Formetanate HCl."},{"key":"ref_38","unstructured":"R Core Team (2019). A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing; 2012, R Foundation for Statistical Computing."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Wickham, H. (2009). Ggplot2: Elegant Graphics for Data Analysis, Springer.","DOI":"10.1007\/978-0-387-98141-3"},{"key":"ref_40","unstructured":"(2019, November 01). RPostgreSQL: R Interface to the \u2018PostgreSQL\u2019 Database System. Available online: https:\/\/cran.r-project.org\/web\/packages\/RPostgreSQL\/index.html."},{"key":"ref_41","unstructured":"WoRMS (2019). Editorial Board World Register of Marine Species, WoRMS."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Stephen, C.E., Mount, D.I., Hansen, D.J., Gentile, J.R., Chapman, G.A., and Brungs, W.A. (1985). Guidelines for Deriving Numerical National Water Quality Criteria for the Protection of Aquatic Organisms and Their Uses.","DOI":"10.1520\/STP36287S"},{"key":"ref_43","unstructured":"Guiry, M.D., and Guiry, G.M. (2019, August 10). AlgaeBase. Available online: https:\/\/www.algaebase.org."},{"key":"ref_44","unstructured":"(2019, November 01). Pesticide Use in U.S. Crop Production: 2002. Available online: https:\/\/pdfs.semanticscholar.org\/739e\/6ad4b29880c43ab7e8509e0af53111c69735.pdf."},{"key":"ref_45","first-page":"360","article-title":"Advanced statistics: Bootstrapping confidence intervals for statistics with \u201cdifficult\u201d distributions","volume":"12","author":"Haukoos","year":"2005","journal-title":"Acad. Emerg. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1177\/1094428105280059","article-title":"Bootstrapped confidence intervals as an approach to statistical inference","volume":"8","author":"Wood","year":"2005","journal-title":"Organ. Res. Methods"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/sim.3471","article-title":"Inference by eye: Reading the overlap of independent confidence intervals","volume":"28","author":"Cumming","year":"2009","journal-title":"Stat. Med."}],"container-title":["Data"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2306-5729\/4\/4\/150\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:42:25Z","timestamp":1760190145000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2306-5729\/4\/4\/150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,14]]},"references-count":47,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,12]]}},"alternative-id":["data4040150"],"URL":"https:\/\/doi.org\/10.3390\/data4040150","relation":{},"ISSN":["2306-5729"],"issn-type":[{"value":"2306-5729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,14]]}}}