{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T16:15:18Z","timestamp":1760890518008,"version":"build-2065373602"},"reference-count":21,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T00:00:00Z","timestamp":1680739200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Education and Science of the Russian Federation","award":["RF00121X0004"],"award-info":[{"award-number":["RF00121X0004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Data"],"abstract":"<jats:p>Vestibular schwannomas are relatively rare intracranial tumors compared to other brain tumors. Data on the molecular features, especially on schwannoma proteome, are scarce. The 41 cerebrospinal fluid (liquor) samples were obtained during the surgical removal of vestibular schwannoma. Obtained peptide samples were analyzed by shotgun LC-MS\/MS high-resolution mass spectrometry. The same peptide samples were spiked with 148 stable isotopically labeled peptide standards (SIS) followed by alkaline fractionation and scheduled multiple reaction monitoring (MRM) for quantitative analysis. The natural counterparts of SIS peptides were mapped onto 111 proteins that were Food and Drug Administration (FDA)-approved for diagnostic use. As a result, 525 proteins were identified by shotgun LC-MS\/MS with high confidence (at least two peptides per protein, FDR &lt; 1%) in liquor samples. Absolute quantitative concentrations were obtained for 54 FDA-approved proteins detected in at least five experimental samples. Since there is lack of data on the molecular landscape of vestibular schwannoma, the obtained datasets are unique and one of the first in its field.<\/jats:p>","DOI":"10.3390\/data8040071","type":"journal-article","created":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T02:29:58Z","timestamp":1680748198000},"page":"71","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Proteomic Shotgun and Targeted Mass Spectrometric Datasets of Cerebrospinal Fluid (Liquor) Derived from Patients with Vestibular Schwannoma"],"prefix":"10.3390","volume":"8","author":[{"given":"Svetlana","family":"Novikova","sequence":"first","affiliation":[{"name":"Institute of Biomedical Chemistry, 119121 Moscow, Russia"}]},{"given":"Natalia","family":"Soloveva","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Chemistry, 119121 Moscow, Russia"}]},{"given":"Tatiana","family":"Farafonova","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Chemistry, 119121 Moscow, Russia"}]},{"given":"Olga","family":"Tikhonova","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Chemistry, 119121 Moscow, Russia"}]},{"given":"Vadim","family":"Shimansky","sequence":"additional","affiliation":[{"name":"N.N. Burdenko National Scientific and Practical Center for Neurosurgery, 125047 Moscow, Russia"}]},{"given":"Ivan","family":"Kugushev","sequence":"additional","affiliation":[{"name":"N.N. Burdenko National Scientific and Practical Center for Neurosurgery, 125047 Moscow, Russia"}]},{"given":"Victor","family":"Zgoda","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Chemistry, 119121 Moscow, Russia"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.17116\/neiro20188206138","article-title":"Surgical approach to resection of vestibular schwannomas following stereotactic radiological treatment. Surgical outcomes and morphological changes in tumors after radiotherapy","volume":"82","author":"Shimansky","year":"2018","journal-title":"Zhurnal Vopr. Nejrokhirurgii Im. N.N. 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