{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T05:18:21Z","timestamp":1774675101805,"version":"3.50.1"},"reference-count":47,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,4,20]],"date-time":"2024-04-20T00:00:00Z","timestamp":1713571200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010767","name":"Innovative Medicines Initiative","doi-asserted-by":"publisher","award":["777389"],"award-info":[{"award-number":["777389"]}],"id":[{"id":"10.13039\/501100010767","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Data"],"abstract":"<jats:p>The reuse of paediatric individual patient data (IPD) from clinical trials (CTs) is essential to overcome specific ethical, regulatory, methodological, and economic issues that hinder the progress of paediatric research. Sharing data through repositories enables the aggregation and dissemination of clinical information, fosters collaboration between researchers, and promotes transparency. This work aims to identify and describe existing data-sharing repositories (DSRs) developed to store, share, and reuse paediatric IPD from CTs. A rapid review of platforms providing access to electronic DSRs was conducted. A two-stage process was used to characterize DSRs: a first step of identification, followed by a second step of analysis using a set of eight purpose-built indicators. From an initial set of forty-five publicly available DSRs, twenty-one DSRs were identified as meeting the eligibility criteria. Only two DSRs were found to be totally focused on the paediatric population. Despite an increased awareness of the importance of data sharing, the results of this study show that paediatrics remains an area in which targeted efforts are still needed. Promoting initiatives to raise awareness of these DSRs and creating ad hoc measures and common standards for the sharing of paediatric CT data could help to bridge this gap in paediatric research.<\/jats:p>","DOI":"10.3390\/data9040059","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T09:53:52Z","timestamp":1713779632000},"page":"59","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Mapping of Data-Sharing Repositories for Paediatric Clinical Research\u2014A Rapid Review"],"prefix":"10.3390","volume":"9","author":[{"given":"Mariagrazia","family":"Felisi","sequence":"first","affiliation":[{"name":"Consorzio per Valutazioni Biologiche e Farmacologiche (CVBF), Via Luigi Porta, 14, 27100 Pavia, 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Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"j2372","DOI":"10.1136\/bmj.j2372","article-title":"Data Sharing Statements for Clinical Trials","volume":"357","author":"Taichman","year":"2017","journal-title":"BMJ"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e181065","DOI":"10.1001\/jamanetworkopen.2018.1065","article-title":"Age of Data at the Time of Publication of Contemporary Clinical Trials","volume":"1","author":"Welsh","year":"2018","journal-title":"JAMA Netw. Open"},{"key":"ref_10","unstructured":"Committee on Strategies for Responsible Sharing of Clinical Trial Data, Board on Health Sciences Policy, and Institute of Medicine Guiding Principles for Sharing Clinical Trial Data (2015). Sharing Clinical Trial Data: Maximizing Benefits, Minimizing Risk, National Academies Press."},{"key":"ref_11","unstructured":"(2023, October 03). International Coalition of Medicines Regulatory Authorities (ICMRA) and the World Health Organization (WHO) Joint Statement on Transparency and Data Integrit. Available online: Https:\/\/Www.Icmra.Info\/Drupal\/En\/Covid-19\/Joint_statement_on_transparency_and_data_integrity."},{"key":"ref_12","unstructured":"(2023, October 03). U.S. Food and Drug Administration Pediatric Research Equity Act | PREA, Available online: Https:\/\/Www.Fda.Gov\/Drugs\/Development-Resources\/Pediatric-Research-Equity-Act-Prea."},{"key":"ref_13","unstructured":"(2023, October 03). U.S. Food and Drug Administration Best Pharmaceuticals for Children Act (BPCA), Available online: Https:\/\/Www.Fda.Gov\/Drugs\/Development-Resources\/Best-Pharmaceuticals-Children-Act-Bpca."},{"key":"ref_14","unstructured":"(2024, March 11). European Parliament, the Council of the European Union Regulation (EC) No 1901\/2006 of The European Parliament and of the Council of 12 December 2006 on Medicinal Products for Paediatric Use, and Regulation (EC) No 1902\/2006 Amending Regulation in Which Changes to the Original Text Were Introduced Relating to Decision Procedures for the European Commission. Available online: https:\/\/www.ema.europa.eu\/en\/human-regulatory-overview\/paediatric-medicines-overview\/paediatric-regulation."},{"key":"ref_15","unstructured":"European Commission (2024, March 11). Evaluation of Medicines for Rare Diseases and Children Legislation. European Commission. Available online: https:\/\/health.ec.europa.eu\/medicinal-products\/medicines-children\/evaluation-medicines-rare-diseases-and-children-legislation_en."},{"key":"ref_16","unstructured":"(2023, October 03). European Parliament, the Council of the European Union REGULATION (EU) No 536\/2014 of the European Parliament and of the Council of 16 April 2014 on Clinical Trials on Medicinal Products for Human Use, and Repealing Directive 2001\/20\/EC. Available online: Https:\/\/Eur-Lex.Europa.Eu\/Eli\/Reg\/2014\/536\/Oj."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"i5295","DOI":"10.1136\/bmj.i5295","article-title":"Beyond Open Data: Realising the Health Benefits of Sharing Data: Table 1","volume":"355","author":"Pisani","year":"2016","journal-title":"BMJ"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e018647","DOI":"10.1136\/bmjopen-2017-018647","article-title":"Sharing and Reuse of Individual Participant Data from Clinical Trials: Principles and Recommendations","volume":"7","author":"Ohmann","year":"2017","journal-title":"BMJ Open"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1056\/NEJMsb1708278","article-title":"Data Sharing from Clinical Trials\u2014A Research Funder\u2019s Perspective","volume":"377","author":"Kiley","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"g237","DOI":"10.1136\/bmj.g237","article-title":"Data Sharing in Research: Benefits and Risks for Clinicians","volume":"348","author":"Antman","year":"2014","journal-title":"BMJ"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1007\/s00330-017-5165-5","article-title":"To Share or Not to Share? Expected Pros and Cons of Data Sharing in Radiological Research","volume":"28","author":"Sardanelli","year":"2018","journal-title":"Eur. Radiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1745-6215-11-9","article-title":"Preparing Raw Clinical Data for Publication: Guidance for Journal Editors, Authors, and Peer Reviewers","volume":"11","author":"Hrynaszkiewicz","year":"2010","journal-title":"Trials"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1056\/NEJMsa1713258","article-title":"Clinical Trial Participants\u2019 Views of the Risks and Benefits of Data Sharing","volume":"378","author":"Mello","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"160018","DOI":"10.1038\/sdata.2016.18","article-title":"The FAIR Guiding Principles for Scientific Data Management and Stewardship","volume":"3","author":"Wilkinson","year":"2016","journal-title":"Sci Data"},{"key":"ref_25","unstructured":"(2023, October 03). InfoScipedia-IGI Global Publishing House. Available online: https:\/\/Www.Igi-Global.Com\/Dictionary\/Digital-Repositories\/7693."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1186\/s13063-019-3253-3","article-title":"Evaluation of Repositories for Sharing Individual-Participant Data from Clinical Studies","volume":"20","author":"Banzi","year":"2019","journal-title":"Trials"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Forero, D.A., Curioso, W.H., and Patrinos, G.P. (2021). The Importance of Adherence to International Standards for Depositing Open Data in Public Repositories. BMC Res. Notes, 14.","DOI":"10.1186\/s13104-021-05817-z"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Speer, E.M., Lee, L.K., Bourgeois, F.T., Gitterman, D., Hay, W.W., Davis, J.M., and Javier, J.R. (2023). The State and Future of Pediatric Research\u2014An Introductory Overview: The State and Future of Pediatric Research Series. Pediatr. Res., 1\u20135.","DOI":"10.1038\/s41390-022-02439-4"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"166.e7","DOI":"10.1016\/j.amjmed.2005.10.036","article-title":"Current Concepts in Validity and Reliability for Psychometric Instruments: Theory and Application","volume":"119","author":"Cook","year":"2006","journal-title":"Am. J. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"276","DOI":"10.11613\/BM.2012.031","article-title":"Interrater Reliability: The Kappa Statistic","volume":"22","author":"McHugh","year":"2012","journal-title":"Biochem. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1207\/s15327906mbr1803_4","article-title":"A Comparison of Cluster Analysis Techniques Withing a Sequential Validation Framework","volume":"18","author":"Morey","year":"1983","journal-title":"Multivar. Behav. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"100","DOI":"10.2307\/2346830","article-title":"Algorithm AS 136: A K-Means Clustering Algorithm","volume":"28","author":"Hartigan","year":"1979","journal-title":"Appl. Stat."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1214\/aos\/1176344136","article-title":"Estimating the Dimension of a Model","volume":"6","author":"Schwarz","year":"1978","journal-title":"Ann. Statist."},{"key":"ref_34","unstructured":"(2004). International Committee of Medical Journal Editors (ICMJE) International Committee of Medical Journal Editors (ICMJE): Uniform Requirements for Manuscripts Submitted to Biomedical Journals: Writing and Editing for Biomedical Publication. Haematologica, 89, 264."},{"key":"ref_35","unstructured":"United States Congress (2023, October 03). Senate Bill S. 558 PUBLIC LAW 110\u201385\u2014SEPT. 27, 2007, Available online: Https:\/\/Www.Govinfo.Gov\/Content\/Pkg\/PLAW-110publ85\/Pdf\/PLAW-110publ85.Pdf#page=82."},{"key":"ref_36","unstructured":"(2023, October 03). Summaries of Clinical Trial Results for Laypersons. Available online: https:\/\/health.ec.europa.eu\/system\/files\/2020-02\/2017_01_26_summaries_of_ct_results_for_laypersons_0.pdf."},{"key":"ref_37","unstructured":"(2023, October 03). European Medicines Agency External Guidance on the Implementation of the European Medicines Agency Policy on the Publication of Clinical Data for Medicinal Products for Human Use. Available online: Https:\/\/Www.Ema.Europa.Eu\/En\/Documents\/Regulatory-Procedural-Guideline\/External-Guidance-Implementation-European-Medicines-Agency-Policy-Publication-Clinical-Data_en-1.Pdf."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e038887","DOI":"10.1136\/bmjopen-2020-038887","article-title":"Data-Sharing Recommendations in Biomedical Journals and Randomised Controlled Trials: An Audit of Journals Following the ICMJE Recommendations","volume":"10","author":"Siebert","year":"2020","journal-title":"BMJ Open"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1126\/science.aab2374","article-title":"Promoting an Open Research Culture","volume":"348","author":"Nosek","year":"2015","journal-title":"Science"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Anthony, N., Pellen, C., Ohmann, C., Moher, D., and Naudet, F. (2021). Social Media Attention and Citations of Published Outputs from Re-Use of Clinical Trial Data: A Matched Comparison with Articles Published in the Same Journals. BMC Med. Res. Methodol., 21.","DOI":"10.1186\/s12874-021-01311-z"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e049228","DOI":"10.1136\/bmjopen-2021-049228","article-title":"Status, Use and Impact of Sharing Individual Participant Data from Clinical Trials: A Scoping Review","volume":"11","author":"Ohmann","year":"2021","journal-title":"BMJ Open"},{"key":"ref_42","unstructured":"(2023, October 03). Clinical Research Data Sharing Alliance: CRDSA, Work Group: Data Protection A Review of Biopharma Sponsor Data Sharing Policies and Protection Methodologies 2023\u2014Version: 2.0 2023. Available online: https:\/\/crdsalliance.org\/?smd_process_download=1&download_id=469."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"McMurry, A.J., Murphy, S.N., MacFadden, D., Weber, G., Simons, W.W., Orechia, J., Bickel, J., Wattanasin, N., Gilbert, C., and Trevvett, P. (2013). SHRINE: Enabling nationally scalable multi-site disease studies. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0055811"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s13023-023-02650-4","article-title":"Towards the international interoperability of clinical research networks for rare diseases: Recommendations from the IRDiRC Task Force","volume":"18","author":"Nabbout","year":"2023","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"h2147","DOI":"10.1136\/bmj.h2147","article-title":"The PRECIS-2 tool: Designing trials that are fit for purpose","volume":"350","author":"Loudon","year":"2015","journal-title":"BMJ"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/s41746-019-0158-1","article-title":"Why digital medicine depends on interoperability","volume":"2","author":"Lehne","year":"2019","journal-title":"NPJ Digit. Med."},{"key":"ref_47","unstructured":"Hodson, S., Jones, S., Collins, S., Genova, F., Harrower, N., Mietchen, D., Petrauskait\u00e9, R., and Wittenburg, P. (2018). FAIR Data Action Plan: Interim Recommendations and Actions from the European Commission Expert Group on FAIR Data, Zenodo."}],"updated-by":[{"DOI":"10.3390\/data11040069","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2024,4,20]],"date-time":"2024-04-20T00:00:00Z","timestamp":1713571200000}}],"container-title":["Data"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2306-5729\/9\/4\/59\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T15:08:20Z","timestamp":1774624100000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2306-5729\/9\/4\/59"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,20]]},"references-count":47,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,4]]}},"alternative-id":["data9040059"],"URL":"https:\/\/doi.org\/10.3390\/data9040059","relation":{},"ISSN":["2306-5729"],"issn-type":[{"value":"2306-5729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,20]]}}}