{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:21:51Z","timestamp":1772252511775,"version":"3.50.1"},"reference-count":20,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T00:00:00Z","timestamp":1726531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University Research Priority Program (URPP) \u2018Adaptive Brain Circuits in Development and Learning (AdaBD)\u2019 of the University of Zurich"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Data"],"abstract":"<jats:p>We present the Open Spina Bifida Aperta (OSBA) atlas, an open atlas and set of neuroimaging templates for spina bifida aperta (SBA). Traditional brain atlases may not adequately capture anatomical variations present in pediatric or disease-specific cohorts. The OSBA atlas fills this gap by representing the computationally averaged anatomy of the neonatal brain with SBA after fetal surgical repair. The OSBA atlas was constructed using structural T2-weighted and diffusion tensor MRIs of 28 newborns with SBA who underwent prenatal surgical correction. The corrected gestational age at MRI was 38.1 \u00b1 1.1 weeks (mean \u00b1 SD). The OSBA atlas consists of T2-weighted and fractional anisotropy templates, along with nine tissue prior maps and region of interest (ROI) delineations. The OSBA atlas offers a standardized reference space for spatial normalization and anatomical ROI definition. Our image segmentation and cortical ribbon definition are based on a human-in-the-loop approach, which includes manual segmentation. The precise alignment of the ROIs was achieved by a combination of manual image alignment and automated, non-linear image registration. From the clinical and neuroimaging perspective, the OSBA atlas enables more accurate spatial standardization and ROI-based analyses and supports advanced analyses such as diffusion tractography and connectomic studies in newborns affected by this condition.<\/jats:p>","DOI":"10.3390\/data9090107","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T00:51:43Z","timestamp":1726620703000},"page":"107","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["OSBA: An Open Neonatal Neuroimaging Atlas and Template for Spina Bifida Aperta"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4728-6381","authenticated-orcid":false,"given":"Anna","family":"Speckert","sequence":"first","affiliation":[{"name":"Center for MR-Research, University Children\u2019s Hospital Zurich, 8032 Zurich, Switzerland"},{"name":"University Research Priority Program (URPP), Adaptive Brain Circuits in Development and Learning (AdaBD), University of Zurich, 8057 Zurich, Switzerland"}]},{"given":"Hui","family":"Ji","sequence":"additional","affiliation":[{"name":"Center for MR-Research, University Children\u2019s Hospital Zurich, 8032 Zurich, Switzerland"}]},{"given":"Kelly","family":"Payette","sequence":"additional","affiliation":[{"name":"Center for MR-Research, University Children\u2019s Hospital Zurich, 8032 Zurich, Switzerland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4920-9764","authenticated-orcid":false,"given":"Patrice","family":"Grehten","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, University Children\u2019s Hospital Zurich, 8032 Zurich, Switzerland"},{"name":"The Zurich Center for Fetal Diagnosis and Therapy, University Children\u2019s Hospital Zurich, 8032 Zurich, Switzerland"}]},{"given":"Raimund","family":"Kottke","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, University Children\u2019s Hospital Zurich, 8032 Zurich, Switzerland"},{"name":"The Zurich Center for Fetal Diagnosis and Therapy, University Children\u2019s Hospital Zurich, 8032 Zurich, Switzerland"}]},{"given":"Samuel","family":"Ackermann","sequence":"additional","affiliation":[{"name":"Center for MR-Research, University Children\u2019s Hospital Zurich, 8032 Zurich, Switzerland"}]},{"given":"Beth","family":"Padden","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rehabilitation, University Children\u2019s Hospital Zurich, 8032 Zurich, Switzerland"},{"name":"Zurich Center for Spina Bifida, University Children\u2019s Hospital Zurich, 8032 Zurich, Switzerland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4344-8441","authenticated-orcid":false,"given":"Luca","family":"Mazzone","sequence":"additional","affiliation":[{"name":"Zurich Center for Spina Bifida, University Children\u2019s Hospital Zurich, 8032 Zurich, Switzerland"},{"name":"Department of Pediatric Surgery, University Children\u2019s Hospital Zurich, 8032 Zurich, Switzerland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6418-1136","authenticated-orcid":false,"given":"Ueli","family":"Moehrlen","sequence":"additional","affiliation":[{"name":"Zurich Center for Spina Bifida, University Children\u2019s Hospital Zurich, 8032 Zurich, Switzerland"},{"name":"Department of Pediatric Surgery, University Children\u2019s Hospital Zurich, 8032 Zurich, Switzerland"},{"name":"Faculty of Medicine, University of Zurich, 8057 Zurich, Switzerland"}]},{"name":"Spina Bifida Study Group Zurich","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6291-9889","authenticated-orcid":false,"given":"Andras","family":"Jakab","sequence":"additional","affiliation":[{"name":"Center for MR-Research, University Children\u2019s Hospital Zurich, 8032 Zurich, Switzerland"},{"name":"University Research Priority Program (URPP), Adaptive Brain Circuits in Development and Learning (AdaBD), University of Zurich, 8057 Zurich, Switzerland"},{"name":"Faculty of Medicine, University of Zurich, 8057 Zurich, Switzerland"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.neuroimage.2018.04.003","article-title":"Baby Brain Atlases","volume":"185","author":"Oishi","year":"2019","journal-title":"Neuroimage"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"123","DOI":"10.12688\/openreseurope.13914.2","article-title":"A Spatio-Temporal Atlas of the Developing Fetal Brain with Spina Bifida Aperta","volume":"1","author":"Fidon","year":"2022","journal-title":"Open Res. 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