{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T01:44:42Z","timestamp":1781660682480,"version":"3.54.5"},"reference-count":244,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2013,12,27]],"date-time":"2013-12-27T00:00:00Z","timestamp":1388102400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Entropy"],"abstract":"<jats:p>We review a selection of methods for performing enhanced sampling in molecular dynamics simulations. We consider methods based on collective variable biasing and on tempering, and offer both historical and contemporary perspectives. In collective-variable biasing, we first discuss methods stemming from thermodynamic integration that use mean force biasing, including the adaptive biasing force algorithm and temperature acceleration. We then turn to methods that use bias potentials, including umbrella sampling and metadynamics. We next consider parallel tempering and replica-exchange methods. We conclude with a brief presentation of some combination methods.<\/jats:p>","DOI":"10.3390\/e16010163","type":"journal-article","created":{"date-parts":[[2013,12,27]],"date-time":"2013-12-27T12:54:46Z","timestamp":1388148886000},"page":"163-199","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":392,"title":["Enhanced Sampling in Molecular Dynamics Using Metadynamics, Replica-Exchange, and Temperature-Acceleration"],"prefix":"10.3390","volume":"16","author":[{"given":"Cameron","family":"Abrams","sequence":"first","affiliation":[{"name":"Department of Chemical and Biological Engineering, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Bussi","sequence":"additional","affiliation":[{"name":"Scuola Internazionale Superiore di Studi Avanzati (SISSA), via Bonomea 265, Trieste 34136, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2013,12,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1021\/cr00023a004","article-title":"Free-energy calculations\u2014applications to chemical and biochemical phenomena","volume":"93","author":"Kollman","year":"1993","journal-title":"Chem. 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