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In the case of tonic-clonic epileptic electroencephalographic (EEG) analysis, we show that appropriate information theory tools provide valuable insights into the dynamics of neural activity. Our purpose is to demonstrate the feasibility of the maximum entropy principle to anticipate tonic-clonic seizure in patients with epilepsy.<\/jats:p>","DOI":"10.3390\/e16084603","type":"journal-article","created":{"date-parts":[[2014,8,18]],"date-time":"2014-08-18T11:17:36Z","timestamp":1408360656000},"page":"4603-4611","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A Maximum Entropy Approach for Predicting Epileptic Tonic-Clonic Seizure"],"prefix":"10.3390","volume":"16","author":[{"given":"Maria","family":"Mart\u00edn","sequence":"first","affiliation":[{"name":"Depto. de Matem\u00e1tica, Fac. de Cs. Exactas, Universidad Nacional de La Plata, 1900 La Plata, Argentina"},{"name":"Instituto de F\u00edsica (IFLP-CCT-CONICET), Universidad Nacional de La Plata, C.C. 727, 1900La Plata, Argentina"}]},{"given":"Angelo","family":"Plastino","sequence":"additional","affiliation":[{"name":"Instituto de F\u00edsica (IFLP-CCT-CONICET), Universidad Nacional de La Plata, C.C. 727, 1900La Plata, Argentina"}]},{"given":"Victoria","family":"Vampa","sequence":"additional","affiliation":[{"name":"Depto. de Cs. 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