{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:33:07Z","timestamp":1772325187198,"version":"3.50.1"},"reference-count":60,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2014,12,22]],"date-time":"2014-12-22T00:00:00Z","timestamp":1419206400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"publisher","award":["2010\/52070-4"],"award-info":[{"award-number":["2010\/52070-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CAPES-PVE","award":["23028.007721\/2013-4"],"award-info":[{"award-number":["23028.007721\/2013-4"]}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["311938\/2013-2"],"award-info":[{"award-number":["311938\/2013-2"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Entropy"],"abstract":"<jats:p>Short-term complexity of heart period (HP) and systolic arterial pressure (SAP) was computed to detect age and gender influences over cardiovascular control in resting supine condition (REST) and during standing (STAND). Healthy subjects (n = 110, men = 55) were equally divided into five groups (21\u201330; 31\u201340; 41\u201350; 51\u201360; and 61\u201370 years of age). HP and SAP series were recorded for 15 min at REST and during STAND. A normalized complexity index (NCI) based on conditional entropy was assessed. At REST we found that both NCIHP and NCISAP decreased with age in the overall population, but only women were responsible for this trend. During STAND we observed that both NCIHP and NCISAP were unrelated to age in the overall population, even when divided by gender. When the variation of NCI in response to STAND (\u0394NCI = NCI at REST-NCI during STAND) was computed individually, we found that \u0394NCIHP progressively decreased with age in the overall population, and women were again responsible for this trend. Conversely, \u0394NCISAP was unrelated to age and gender. This study stresses that the complexity of cardiovascular control and its ability to respond to stressors are more importantly lost with age in women than in men.<\/jats:p>","DOI":"10.3390\/e16126686","type":"journal-article","created":{"date-parts":[[2014,12,22]],"date-time":"2014-12-22T08:31:01Z","timestamp":1419237061000},"page":"6686-6704","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Effect of the Postural Challenge on the Dependence of the Cardiovascular Control Complexity on Age"],"prefix":"10.3390","volume":"16","author":[{"given":"Aparecida","family":"Catai","sequence":"first","affiliation":[{"name":"Cardiovascular Physiotherapy Laboratory, Nucleus of Research in Physical Exercise, Department of Physiotherapy, Federal University of S\u00e3o Carlos, Rodovia Washington Lu\u00eds, km 235, Monjolinho, 13565-905 S\u00e3o Carlos, SP, Brazil"}]},{"given":"Anielle","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Cardiovascular Physiotherapy Laboratory, Nucleus of Research in Physical Exercise, Department of Physiotherapy, Federal University of S\u00e3o Carlos, Rodovia Washington Lu\u00eds, km 235, Monjolinho, 13565-905 S\u00e3o Carlos, SP, Brazil"},{"name":"Research Laboratory on Healthy Aging, Department of Physiotherapy, Federal University of S\u00e3o Carlos, Rodovia Washington Lu\u00eds, km 235, Monjolinho, 13565-905 S\u00e3o Carlos, SP, Brazil"}]},{"given":"Nat\u00e1lia","family":"Perseguini","sequence":"additional","affiliation":[{"name":"Cardiovascular Physiotherapy Laboratory, Nucleus of Research in Physical Exercise, Department of Physiotherapy, Federal University of S\u00e3o Carlos, Rodovia Washington Lu\u00eds, km 235, Monjolinho, 13565-905 S\u00e3o Carlos, SP, Brazil"}]},{"given":"Juliana","family":"Milan","sequence":"additional","affiliation":[{"name":"Cardiovascular Physiotherapy Laboratory, Nucleus of Research in Physical Exercise, Department of Physiotherapy, Federal University of S\u00e3o Carlos, Rodovia Washington Lu\u00eds, km 235, Monjolinho, 13565-905 S\u00e3o Carlos, SP, Brazil"}]},{"given":"Vinicius","family":"Minatel","sequence":"additional","affiliation":[{"name":"Cardiovascular Physiotherapy Laboratory, Nucleus of Research in Physical Exercise, Department of Physiotherapy, Federal University of S\u00e3o Carlos, Rodovia Washington Lu\u00eds, km 235, Monjolinho, 13565-905 S\u00e3o Carlos, SP, Brazil"}]},{"given":"Patr\u00edcia","family":"Rehder-Santos","sequence":"additional","affiliation":[{"name":"Cardiovascular Physiotherapy Laboratory, Nucleus of Research in Physical Exercise, Department of Physiotherapy, Federal University of S\u00e3o Carlos, Rodovia Washington Lu\u00eds, km 235, Monjolinho, 13565-905 S\u00e3o Carlos, SP, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5846-4164","authenticated-orcid":false,"given":"Andrea","family":"Marchi","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care Unit, Humanitas Clinical and Research Center, Via Manzoni 56, 20089 Rozzano, Italy"}]},{"given":"Vlasta","family":"Bari","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic, Vascular Anesthesia and Intensive Care, IRCCS Policlinico San Donato, Via Morandi 30, 20097 San Donato Milanese, Milan, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6720-9824","authenticated-orcid":false,"given":"Alberto","family":"Porta","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences for Health, University of Milan, Via R. Galeazzi 4, 20161 Milan, Italy"},{"name":"IRCCS Galeazzi Orthopedic Institute, Via R. Galeazzi 4, 20161 Milan, Italy"}]}],"member":"1968","published-online":{"date-parts":[[2014,12,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0197-4580(01)00266-4","article-title":"What is physiologic complexity and how does it change with aging and disease?","volume":"23","author":"Goldberger","year":"2002","journal-title":"Neurobiol. 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