{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:35:27Z","timestamp":1760549727952,"version":"build-2065373602"},"reference-count":25,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2015,3,23]],"date-time":"2015-03-23T00:00:00Z","timestamp":1427068800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002836","name":"Chang Gung University","doi-asserted-by":"publisher","award":["CMRP D1C0031"],"award-info":[{"award-number":["CMRP D1C0031"]}],"id":[{"id":"10.13039\/501100002836","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Entropy"],"abstract":"<jats:p>While unique phenomena exist at fluid-solid phase intersections, many interfacial phenomena manifest solely on limited scales\u2014i.e., the nm-mm ranges\u2014which stifles their application potential. Here, we constructed microfluidic chips that utilize the unique long-distance interface effects of the Solute-Exclusion Zone (EZ) phenomenon to mix, separate, and guide samples in desired directions within microfluidic channels. On our \u201cEZ Chip\u201d, we utilized the interfacial force generated by EZs to transport specimens across streamlines without the need of an off-chip power source. The advantages of easy-integration, low fabrication cost, and no off-chip energy input make the EZ suitable for independent, portable lab-on-chip system applications.<\/jats:p>","DOI":"10.3390\/e17031466","type":"journal-article","created":{"date-parts":[[2015,3,23]],"date-time":"2015-03-23T12:17:00Z","timestamp":1427113020000},"page":"1466-1476","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Solute-Exclusion Zone: A Promising Application for Mirofluidics"],"prefix":"10.3390","volume":"17","author":[{"given":"Chi-Shuo","family":"Chen","sequence":"first","affiliation":[{"name":"Bioengineering Department, University of California, Merced,  CA 94343,  USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Farr","sequence":"additional","affiliation":[{"name":"Bioengineering Department, University of California, Merced,  CA 94343,  USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesse","family":"Anaya","sequence":"additional","affiliation":[{"name":"Bioengineering Department, University of California, Merced,  CA 94343,  USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Chen","sequence":"additional","affiliation":[{"name":"Bioengineering Department, University of California, Merced,  CA 94343,  USA"},{"name":"MicroBase Technology Corp., Bade City, Taoyuan, 33464, Taiwan"},{"name":"Center for Biomedical Engineering, Chang Gung University, Taoyuan, 33302, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Chun","family":"Chin","sequence":"additional","affiliation":[{"name":"Bioengineering Department, University of California, Merced,  CA 94343,  USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2015,3,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1128\/mr.54.4.432-449.1990","article-title":"Role of water in some biological processes","volume":"54","author":"Wiggins","year":"1990","journal-title":"Microbiol. 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