{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T17:21:24Z","timestamp":1784049684679,"version":"3.55.0"},"reference-count":85,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2017,4,24]],"date-time":"2017-04-24T00:00:00Z","timestamp":1492992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Entropy"],"abstract":"<jats:p>We review our simulation results on properties of supercooled confined water. We consider two situations: water confined in a hydrophilic pore that mimics an MCM-41 environment and water at interface with a protein. The behavior upon cooling of the    \u03b1    relaxation of water in both environments is well interpreted in terms of the Mode Coupling Theory of glassy dynamics. Moreover, we find a crossover from a fragile to a strong regime. We relate this crossover to the crossing of the Widom line emanating from the liquid-liquid critical point, and in confinement we connect this crossover also to a crossover of the two body excess entropy of water upon cooling. Hydration water exhibits a second, distinctly slower relaxation caused by its dynamical coupling with the protein. The crossover upon cooling of this long relaxation is related to the protein dynamics.<\/jats:p>","DOI":"10.3390\/e19040185","type":"journal-article","created":{"date-parts":[[2017,4,24]],"date-time":"2017-04-24T13:10:11Z","timestamp":1493039411000},"page":"185","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Slow Dynamics and Structure of Supercooled Water in Confinement"],"prefix":"10.3390","volume":"19","author":[{"given":"Gaia","family":"Camisasca","sequence":"first","affiliation":[{"name":"Dipartimento di Matematica e Fisica, Universit\u00e0 Roma Tre, Roma 00146, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"De Marzio","sequence":"additional","affiliation":[{"name":"Dipartimento di Matematica e Fisica, Universit\u00e0 Roma Tre, Roma 00146, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Rovere","sequence":"additional","affiliation":[{"name":"Dipartimento di Matematica e Fisica, Universit\u00e0 Roma Tre, Roma 00146, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Gallo","sequence":"additional","affiliation":[{"name":"Dipartimento di Matematica e Fisica, Universit\u00e0 Roma Tre, Roma 00146, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,4,24]]},"reference":[{"key":"ref_1","unstructured":"Franks, F. 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