{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T05:40:07Z","timestamp":1771479607171,"version":"3.50.1"},"reference-count":43,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2017,10,24]],"date-time":"2017-10-24T00:00:00Z","timestamp":1508803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Key Program on Natural Scientific Research from the Department of Education of Anhui Province, China","award":["KJ2016A470"],"award-info":[{"award-number":["KJ2016A470"]}]},{"name":"the National Natural Science Foundation, China","award":["61601263"],"award-info":[{"award-number":["61601263"]}]},{"name":"the Natural Science Foundation of Shandong Province, China","award":["ZR2015FQ016"],"award-info":[{"award-number":["ZR2015FQ016"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Entropy"],"abstract":"<jats:p>Entropy measures have been extensively used to assess heart rate variability (HRV), a noninvasive marker of cardiovascular autonomic regulation. It is yet to be elucidated whether those entropy measures can sensitively respond to changes of autonomic balance and whether the responses, if there are any, are consistent across different entropy measures. Sixteen healthy subjects were enrolled in this study. Each subject undertook two 5-min ECG measurements, one in a resting seated position and another while walking on a treadmill at a regular speed of 5 km\/h. For each subject, the two measurements were conducted in a randomized order and a 30-min rest was required between them. HRV time series were derived and were analyzed by eight entropy measures, i.e., approximate entropy (ApEn), corrected ApEn (cApEn), sample entropy (SampEn), fuzzy entropy without removing local trend (FuzzyEn-g), fuzzy entropy with local trend removal (FuzzyEn-l), permutation entropy (PermEn), conditional entropy (CE), and distribution entropy (DistEn). Compared to resting seated position, regular walking led to significantly reduced CE and DistEn (both p \u2264 0.006; Cohen\u2019s d = 0.9 for CE, d = 1.7 for DistEn), and increased PermEn (p &lt; 0.0001; d = 1.9), while all these changes disappeared after performing a linear detrend or a wavelet detrend (&lt;~0.03 Hz) on HRV. In addition, cApEn, SampEn, FuzzyEn-g, and FuzzyEn-l showed significant decreases during regular walking after linear detrending (all p &lt; 0.006; 0.8 &lt; d &lt; 1), while a significantly increased ApEn (p &lt; 0.0001; d = 1.9) and a significantly reduced cApEn (p = 0.0006; d = 0.8) were observed after wavelet detrending. To conclude, multiple entropy analyses should be performed to assess HRV in order for objective results and caution should be paid when drawing conclusions based on observations from a single measure. Besides, results from different studies will not be comparable unless it is clearly stated whether data have been detrended and the methods used for detrending have been specified.<\/jats:p>","DOI":"10.3390\/e19100568","type":"journal-article","created":{"date-parts":[[2017,10,24]],"date-time":"2017-10-24T10:39:18Z","timestamp":1508841558000},"page":"568","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Entropy Analysis of Short-Term Heartbeat Interval Time Series during Regular Walking"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0445-0095","authenticated-orcid":false,"given":"Bo","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Medical Imaging, Bengbu Medical College, Bengbu 233030, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4870-1493","authenticated-orcid":false,"given":"Yudong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Informatics, University of Leicester, Leicester LE1 7RH, UK"}]},{"given":"Chaochao","family":"Yuan","sequence":"additional","affiliation":[{"name":"School of Control Science and Engineering, Shandong University, Jinan 250061, China"}]},{"given":"Shuihua","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Computer Science and Technology, Nanjing Normal University, Nanjing 210023, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4684-4909","authenticated-orcid":false,"given":"Peng","family":"Li","sequence":"additional","affiliation":[{"name":"School of Control Science and Engineering, Shandong University, Jinan 250061, China"}]}],"member":"1968","published-online":{"date-parts":[[2017,10,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0002-9149(91)90445-Q","article-title":"Accuracy of assessment of cardiac vagal tone by heart rate variability in normal subjects","volume":"67","author":"Hayano","year":"1991","journal-title":"Am. 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